Olfactory dysfunction and chronic cognitive impairment following SARS-CoV-2 infection in a sample of older adults from the Andes mountains of Argentina
Abstract: Background: COVID-19 has affected more than 150 million people. The causal coronavirus, SARS-CoV-2 has infected twice as many individuals who have remained asymptomatic. COVID-19 includes central nervous system (CNS) manifestations and may result in chronic neuropsychiatric sequelae. Ris...
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John Wiley & Sons
2022
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| Acceso en línea: | https://repositorio.uca.edu.ar/handle/123456789/13711 |
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I33-R139-123456789-137112024-03-26T10:57:53Z Olfactory dysfunction and chronic cognitive impairment following SARS-CoV-2 infection in a sample of older adults from the Andes mountains of Argentina Zamponi, Hernan P. Juarez Aguaysol, Leonardo Kukoc, Gabriela Domínguez, María Eugenia Pini, Belén Padilla, Eduardo G. Calvó, María Molina-Rangeon, Silvia Beatriz Guerrero, Gonzalo Figueredo Aguiar, Mariana Fumagalli, Emiliano Yécora, Agustín Brugha, Traolach S. Seshadri, Sudha Snyder, Heather M. Erausquin, Gabriel A. de Gonzalez Aleman, Gabriela COVID-19 SARS-CoV-2 DETERIORO COGNITIVO ADULTOS MAYORES DISFUNCION OLFATORIA ANOSMIA PERSISTENTE Abstract: Background: COVID-19 has affected more than 150 million people. The causal coronavirus, SARS-CoV-2 has infected twice as many individuals who have remained asymptomatic. COVID-19 includes central nervous system (CNS) manifestations and may result in chronic neuropsychiatric sequelae. Risk factors for COVID-19 sequelae overlap with those for Alzheimer’s disease (AD), particularly older age and ApoE4 status. The Alzheimer’s Association Consortium on Chronic Neuropsychiatric Sequelae of SARS-CoV-2 infection (CNS SC2) established harmonized definitions, ascertainment and assessment methodologies to evaluate and longitudinally follow up cohorts of older adults with variable exposure to COVID-19. We present preliminary data from CNS SC2 in a prospective cohort of 234 older adult Amerindians from Argentina. Method: Participants are ≥ 60 years recruited from the health registry of the Province of Jujuy containing all SARS-CoV-2 testing data (regardless of clinical status and of the result of the testing). We randomly invite older adults stratified by testing status regardless of symptom severity, a minimum of 3 months after clinical recovery (maximum 6 months); refusal to participate is <45%. Assessment includes interview with the Schedules for Clinical Assessment in Neuropsychiatry (SCAN) and Clinical Dementia Rating scale; neurocognitive assessment; emotional reactivity scale; and neurological assessment including semiquantitative olfactory function test, motor function, coordination and gait. We present here the results of olfactory testing and cognitive assessments. Result: We assessed 233 infected participants and 64 controls. Average duration of formal learning is 9.35 ± 2.6 years and mean age is 66.7 ± 5.13 years. Normative data for the local population were available for Word list, Corsi Blocks, Oral Trails and Five Digit Tests and were used to normalize Z-scores and categorize the sample in 3 groups: normal cognition (NC,44.6%); memory only impairment (MOI,21%); and multiple domain impairment (MDI,34.4%). Individuals with MDI presented severe alterations in short-term memory; semantic memory; naming; executive function and attention compared to NC or MO groups (Table 1). Severity of cognitive impairment was significantly correlated with severity of olfactory dysfunction (χ2 = 13.82; p= 0.003) but not severity of acute COVID-19. Conclusion: Older adults frequently suffer persistent cognitive impairment after recovery from SARS-CoV-2 infection; cognitive impairment is correlated with persistent anosmia. 2022-03-29T12:17:38Z 2022-03-29T12:17:38Z 2021 Artículo Zamponi, H. P. et al. Olfactory dysfunction and chronic cognitive impairment following SARS-CoV-2 infection in a sample of older adults from the Andes mountains of Argentina [en línea]. Alzheimer y dementia. 2021, 17, S6, e057897. doi: 10.1002/alz.057897. Disponible en: https://repositorio.uca.edu.ar/handle/123456789/13711 1552-5279 https://repositorio.uca.edu.ar/handle/123456789/13711 10.1002/alz.057897 eng Acceso abierto http://creativecommons.org/licenses/by-nc-sa/4.0/ application/pdf Argentina John Wiley & Sons Alzheimer y dementia Vol.17, S6, e057897, 2021 |
| institution |
Universidad Católica Argentina |
| institution_str |
I-33 |
| repository_str |
R-139 |
| collection |
Repositorio Institucional de la Universidad Católica Argentina (UCA) |
| language |
Inglés |
| topic |
COVID-19 SARS-CoV-2 DETERIORO COGNITIVO ADULTOS MAYORES DISFUNCION OLFATORIA ANOSMIA PERSISTENTE |
| spellingShingle |
COVID-19 SARS-CoV-2 DETERIORO COGNITIVO ADULTOS MAYORES DISFUNCION OLFATORIA ANOSMIA PERSISTENTE Zamponi, Hernan P. Juarez Aguaysol, Leonardo Kukoc, Gabriela Domínguez, María Eugenia Pini, Belén Padilla, Eduardo G. Calvó, María Molina-Rangeon, Silvia Beatriz Guerrero, Gonzalo Figueredo Aguiar, Mariana Fumagalli, Emiliano Yécora, Agustín Brugha, Traolach S. Seshadri, Sudha Snyder, Heather M. Erausquin, Gabriel A. de Gonzalez Aleman, Gabriela Olfactory dysfunction and chronic cognitive impairment following SARS-CoV-2 infection in a sample of older adults from the Andes mountains of Argentina |
| topic_facet |
COVID-19 SARS-CoV-2 DETERIORO COGNITIVO ADULTOS MAYORES DISFUNCION OLFATORIA ANOSMIA PERSISTENTE |
| description |
Abstract:
Background: COVID-19 has affected more than 150 million people. The causal coronavirus, SARS-CoV-2 has infected twice as many individuals who have remained asymptomatic. COVID-19 includes central nervous system (CNS) manifestations and may
result in chronic neuropsychiatric sequelae. Risk factors for COVID-19 sequelae overlap with those for Alzheimer’s disease (AD), particularly older age and ApoE4 status. The Alzheimer’s Association Consortium on Chronic Neuropsychiatric Sequelae of
SARS-CoV-2 infection (CNS SC2) established harmonized definitions, ascertainment
and assessment methodologies to evaluate and longitudinally follow up cohorts of
older adults with variable exposure to COVID-19. We present preliminary data from
CNS SC2 in a prospective cohort of 234 older adult Amerindians from Argentina.
Method: Participants are ≥ 60 years recruited from the health registry of the Province
of Jujuy containing all SARS-CoV-2 testing data (regardless of clinical status and of
the result of the testing). We randomly invite older adults stratified by testing status
regardless of symptom severity, a minimum of 3 months after clinical recovery (maximum 6 months); refusal to participate is <45%. Assessment includes interview with the
Schedules for Clinical Assessment in Neuropsychiatry (SCAN) and Clinical Dementia
Rating scale; neurocognitive assessment; emotional reactivity scale; and neurological
assessment including semiquantitative olfactory function test, motor function, coordination and gait. We present here the results of olfactory testing and cognitive assessments.
Result: We assessed 233 infected participants and 64 controls. Average duration of
formal learning is 9.35 ± 2.6 years and mean age is 66.7 ± 5.13 years. Normative
data for the local population were available for Word list, Corsi Blocks, Oral Trails and
Five Digit Tests and were used to normalize Z-scores and categorize the sample in 3
groups: normal cognition (NC,44.6%); memory only impairment (MOI,21%); and multiple domain impairment (MDI,34.4%). Individuals with MDI presented severe alterations in short-term memory; semantic memory; naming; executive function and attention compared to NC or MO groups (Table 1). Severity of cognitive impairment was significantly correlated with severity of olfactory dysfunction (χ2 = 13.82; p= 0.003) but
not severity of acute COVID-19.
Conclusion: Older adults frequently suffer persistent cognitive impairment after
recovery from SARS-CoV-2 infection; cognitive impairment is correlated with persistent anosmia. |
| format |
Artículo |
| author |
Zamponi, Hernan P. Juarez Aguaysol, Leonardo Kukoc, Gabriela Domínguez, María Eugenia Pini, Belén Padilla, Eduardo G. Calvó, María Molina-Rangeon, Silvia Beatriz Guerrero, Gonzalo Figueredo Aguiar, Mariana Fumagalli, Emiliano Yécora, Agustín Brugha, Traolach S. Seshadri, Sudha Snyder, Heather M. Erausquin, Gabriel A. de Gonzalez Aleman, Gabriela |
| author_facet |
Zamponi, Hernan P. Juarez Aguaysol, Leonardo Kukoc, Gabriela Domínguez, María Eugenia Pini, Belén Padilla, Eduardo G. Calvó, María Molina-Rangeon, Silvia Beatriz Guerrero, Gonzalo Figueredo Aguiar, Mariana Fumagalli, Emiliano Yécora, Agustín Brugha, Traolach S. Seshadri, Sudha Snyder, Heather M. Erausquin, Gabriel A. de Gonzalez Aleman, Gabriela |
| author_sort |
Zamponi, Hernan P. |
| title |
Olfactory dysfunction and chronic cognitive impairment following SARS-CoV-2 infection in a sample of older adults from the Andes mountains of Argentina |
| title_short |
Olfactory dysfunction and chronic cognitive impairment following SARS-CoV-2 infection in a sample of older adults from the Andes mountains of Argentina |
| title_full |
Olfactory dysfunction and chronic cognitive impairment following SARS-CoV-2 infection in a sample of older adults from the Andes mountains of Argentina |
| title_fullStr |
Olfactory dysfunction and chronic cognitive impairment following SARS-CoV-2 infection in a sample of older adults from the Andes mountains of Argentina |
| title_full_unstemmed |
Olfactory dysfunction and chronic cognitive impairment following SARS-CoV-2 infection in a sample of older adults from the Andes mountains of Argentina |
| title_sort |
olfactory dysfunction and chronic cognitive impairment following sars-cov-2 infection in a sample of older adults from the andes mountains of argentina |
| publisher |
John Wiley & Sons |
| publishDate |
2022 |
| url |
https://repositorio.uca.edu.ar/handle/123456789/13711 |
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