Nanoscale sub-compartmentalization of the dendritic spine compartment

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Abstract: Compartmentalization of the membrane is essential for cells to perform highly specific tasks and spatially constrained biochemical functions in topographically defined areas. These membrane lateral heterogeneities range from nanoscopic dimensions, often involving only a few molecular co...

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Autores principales: Vallés, Ana Sofía, Barrantes, Francisco José
Formato: Artículo
Lenguaje:Inglés
Publicado: MDPI 2021
Materias:
MEMBRANA CELULAR
NEUROTRANSMISORES
CANNABINOIDES
RECEPTORES
Acceso en línea:https://repositorio.uca.edu.ar/handle/123456789/13059
Aporte de:
Repositorio Institucional de la Universidad Católica Argentina (UCA) de Universidad Católica Argentina
id I33-R139-123456789-13059
record_format dspace
spelling I33-R139-123456789-130592023-11-22T22:05:55Z Nanoscale sub-compartmentalization of the dendritic spine compartment Vallés, Ana Sofía Barrantes, Francisco José MEMBRANA CELULAR NEUROTRANSMISORES CANNABINOIDES RECEPTORES Abstract: Compartmentalization of the membrane is essential for cells to perform highly specific tasks and spatially constrained biochemical functions in topographically defined areas. These membrane lateral heterogeneities range from nanoscopic dimensions, often involving only a few molecular constituents, to micron-sized mesoscopic domains resulting from the coalescence of nanodomains. Short-lived domains lasting for a few milliseconds coexist with more stable platforms lasting from minutes to days. This panoply of lateral domains subserves the great variety of demands of cell physiology, particularly high for those implicated in signaling. The dendritic spine, a subcellular structure of neurons at the receiving (postsynaptic) end of central nervous system excitatory synapses, exploits this compartmentalization principle. In its most frequent adult morphology, the mushroom-shaped spine harbors neurotransmitter receptors, enzymes, and scaffolding proteins tightly packed in a volume of a few femtoliters. In addition to constituting a mesoscopic lateral heterogeneity of the dendritic arborization, the dendritic spine postsynaptic membrane is further compartmentalized into spatially delimited nanodomains that execute separate functions in the synapse. This review discusses the functional relevance of compartmentalization and nanodomain organization in synaptic transmission and plasticity and exemplifies the importance of this parcelization in various neurotransmitter signaling systems operating at dendritic spines, using two fast ligand-gated ionotropic receptors, the nicotinic acetylcholine receptor and the glutamatergic receptor, and a second-messenger G-protein coupled receptor, the cannabinoid receptor, as paradigmatic examples. 2021-11-30T16:53:00Z 2021-11-30T16:53:00Z 2021 Artículo Vallés, A.S., Barrantes, F.J. Nanoscale sub-compartmentalization of the dendritic spine compartment [en línea]. Biomolecules. 2021, 11(11) doi:10.3390/biom11111697 Disponible en: https://repositorio.uca.edu.ar/handle/123456789/13059 2218-273X https://repositorio.uca.edu.ar/handle/123456789/13059 10.3390/biom11111697 34827695 eng Acceso abierto http://creativecommons.org/licenses/by-nc-sa/4.0/ application/pdf MDPI Biomolecules. 2021, 11(11)
institution Universidad Católica Argentina
institution_str I-33
repository_str R-139
collection Repositorio Institucional de la Universidad Católica Argentina (UCA)
language Inglés
topic MEMBRANA CELULAR
NEUROTRANSMISORES
CANNABINOIDES
RECEPTORES
spellingShingle MEMBRANA CELULAR
NEUROTRANSMISORES
CANNABINOIDES
RECEPTORES
Vallés, Ana Sofía
Barrantes, Francisco José
Nanoscale sub-compartmentalization of the dendritic spine compartment
topic_facet MEMBRANA CELULAR
NEUROTRANSMISORES
CANNABINOIDES
RECEPTORES
description Abstract: Compartmentalization of the membrane is essential for cells to perform highly specific tasks and spatially constrained biochemical functions in topographically defined areas. These membrane lateral heterogeneities range from nanoscopic dimensions, often involving only a few molecular constituents, to micron-sized mesoscopic domains resulting from the coalescence of nanodomains. Short-lived domains lasting for a few milliseconds coexist with more stable platforms lasting from minutes to days. This panoply of lateral domains subserves the great variety of demands of cell physiology, particularly high for those implicated in signaling. The dendritic spine, a subcellular structure of neurons at the receiving (postsynaptic) end of central nervous system excitatory synapses, exploits this compartmentalization principle. In its most frequent adult morphology, the mushroom-shaped spine harbors neurotransmitter receptors, enzymes, and scaffolding proteins tightly packed in a volume of a few femtoliters. In addition to constituting a mesoscopic lateral heterogeneity of the dendritic arborization, the dendritic spine postsynaptic membrane is further compartmentalized into spatially delimited nanodomains that execute separate functions in the synapse. This review discusses the functional relevance of compartmentalization and nanodomain organization in synaptic transmission and plasticity and exemplifies the importance of this parcelization in various neurotransmitter signaling systems operating at dendritic spines, using two fast ligand-gated ionotropic receptors, the nicotinic acetylcholine receptor and the glutamatergic receptor, and a second-messenger G-protein coupled receptor, the cannabinoid receptor, as paradigmatic examples.
format Artículo
author Vallés, Ana Sofía
Barrantes, Francisco José
author_facet Vallés, Ana Sofía
Barrantes, Francisco José
author_sort Vallés, Ana Sofía
title Nanoscale sub-compartmentalization of the dendritic spine compartment
title_short Nanoscale sub-compartmentalization of the dendritic spine compartment
title_full Nanoscale sub-compartmentalization of the dendritic spine compartment
title_fullStr Nanoscale sub-compartmentalization of the dendritic spine compartment
title_full_unstemmed Nanoscale sub-compartmentalization of the dendritic spine compartment
title_sort nanoscale sub-compartmentalization of the dendritic spine compartment
publisher MDPI
publishDate 2021
url https://repositorio.uca.edu.ar/handle/123456789/13059
work_keys_str_mv AT vallesanasofia nanoscalesubcompartmentalizationofthedendriticspinecompartment
AT barrantesfranciscojose nanoscalesubcompartmentalizationofthedendriticspinecompartment
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