How much time is needed in clinical practice to reach a diagnosis of clinically established Parkinson’s disease?

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Introduction: The implementation of accepted clinical diagnostic criteria has improved the accuracy of a clinical diagnosis of Parkinson’s disease (PD). Time frames of 3 to 10 years have been empirically proposed to reach a diagnosis of clinically established PD. Methods: We explored the time to a F...

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Autores principales: Rossi, Malco Damián, Pérez Lloret, Santiago, Merello, Marcelo
Formato: Artículo
Lenguaje:Inglés
Publicado: Elsevier 2021
Materias:
ENFERMEDAD DE PARKINSON
DIAGNOSTICO MÉDICO
MEDICINA CLINICA
TRASTORNOS DEL MOVIMIENTO
TRATAMIENTO FARMACOLOGICO
Acceso en línea:https://repositorio.uca.edu.ar/handle/123456789/12860
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Repositorio Institucional de la Universidad Católica Argentina (UCA) de Universidad Católica Argentina
id I33-R139-123456789-12860
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spelling I33-R139-123456789-128602023-11-22T22:00:27Z How much time is needed in clinical practice to reach a diagnosis of clinically established Parkinson’s disease? Rossi, Malco Damián Pérez Lloret, Santiago Merello, Marcelo ENFERMEDAD DE PARKINSON DIAGNOSTICO MÉDICO MEDICINA CLINICA TRASTORNOS DEL MOVIMIENTO TRATAMIENTO FARMACOLOGICO Introduction: The implementation of accepted clinical diagnostic criteria has improved the accuracy of a clinical diagnosis of Parkinson’s disease (PD). Time frames of 3 to 10 years have been empirically proposed to reach a diagnosis of clinically established PD. Methods: We explored the time to a Final Clinical Diagnosis (FCD) and the factors that predict faster diagnoses in patients presenting with parkinsonism and/or tremor between 2009 and 2015 at our tertiary center. All patients underwent a standardized workout process to reach a FCD, which included an acute levodopa challenge (LDC) after the first visit. Results: Among the 326 patients included, 215 (66%) received a FCD within the first six months after the LDC. A FCD was reached in 95% and 100% of patients in 33 and 108 months, respectively. PD was the FCD in 196 patients (60.1%). The FCD was reached faster in patients with a positive response to levodopa and when the FCD was PD. Conclusion: The time needed to reach a final diagnosis in the clinical setting was 2.75 years in 95% of patients presenting initially with parkinsonism and/or tremor. Patients with positive responses to levodopa at the LDC, benefited from shorter delays until the FCD. 2021-11-11T19:06:10Z 2021-11-11T19:06:10Z 2021 Artículo Rossi, M. D., Pérez Lloret, S., Merello, M. How much time is needed in clinical practice to reach a diagnosis of clinically established Parkinson’s disease? [en línea]. Parkinsonism & Related Disorders. 2021, 92. doi:10.1016/j.parkreldis.2021.10.016. Disponible en: https://repositorio.uca.edu.ar/handle/123456789/12860 1353-8020 (impreso) https://repositorio.uca.edu.ar/handle/123456789/12860 10.1016/j.parkreldis.2021.10.016 34695656 eng Acceso abierto. 12 meses de embargo http://creativecommons.org/licenses/by-nc-sa/4.0/ application/pdf Elsevier Parkinsonism & Related Disorders. 2021, 92. doi:10.1016/j.parkreldis.2021.10.016
institution Universidad Católica Argentina
institution_str I-33
repository_str R-139
collection Repositorio Institucional de la Universidad Católica Argentina (UCA)
language Inglés
topic ENFERMEDAD DE PARKINSON
DIAGNOSTICO MÉDICO
MEDICINA CLINICA
TRASTORNOS DEL MOVIMIENTO
TRATAMIENTO FARMACOLOGICO
spellingShingle ENFERMEDAD DE PARKINSON
DIAGNOSTICO MÉDICO
MEDICINA CLINICA
TRASTORNOS DEL MOVIMIENTO
TRATAMIENTO FARMACOLOGICO
Rossi, Malco Damián
Pérez Lloret, Santiago
Merello, Marcelo
How much time is needed in clinical practice to reach a diagnosis of clinically established Parkinson’s disease?
topic_facet ENFERMEDAD DE PARKINSON
DIAGNOSTICO MÉDICO
MEDICINA CLINICA
TRASTORNOS DEL MOVIMIENTO
TRATAMIENTO FARMACOLOGICO
description Introduction: The implementation of accepted clinical diagnostic criteria has improved the accuracy of a clinical diagnosis of Parkinson’s disease (PD). Time frames of 3 to 10 years have been empirically proposed to reach a diagnosis of clinically established PD. Methods: We explored the time to a Final Clinical Diagnosis (FCD) and the factors that predict faster diagnoses in patients presenting with parkinsonism and/or tremor between 2009 and 2015 at our tertiary center. All patients underwent a standardized workout process to reach a FCD, which included an acute levodopa challenge (LDC) after the first visit. Results: Among the 326 patients included, 215 (66%) received a FCD within the first six months after the LDC. A FCD was reached in 95% and 100% of patients in 33 and 108 months, respectively. PD was the FCD in 196 patients (60.1%). The FCD was reached faster in patients with a positive response to levodopa and when the FCD was PD. Conclusion: The time needed to reach a final diagnosis in the clinical setting was 2.75 years in 95% of patients presenting initially with parkinsonism and/or tremor. Patients with positive responses to levodopa at the LDC, benefited from shorter delays until the FCD.
format Artículo
author Rossi, Malco Damián
Pérez Lloret, Santiago
Merello, Marcelo
author_facet Rossi, Malco Damián
Pérez Lloret, Santiago
Merello, Marcelo
author_sort Rossi, Malco Damián
title How much time is needed in clinical practice to reach a diagnosis of clinically established Parkinson’s disease?
title_short How much time is needed in clinical practice to reach a diagnosis of clinically established Parkinson’s disease?
title_full How much time is needed in clinical practice to reach a diagnosis of clinically established Parkinson’s disease?
title_fullStr How much time is needed in clinical practice to reach a diagnosis of clinically established Parkinson’s disease?
title_full_unstemmed How much time is needed in clinical practice to reach a diagnosis of clinically established Parkinson’s disease?
title_sort how much time is needed in clinical practice to reach a diagnosis of clinically established parkinson’s disease?
publisher Elsevier
publishDate 2021
url https://repositorio.uca.edu.ar/handle/123456789/12860
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