Falls risk, circadian rhythms and melatonin : current perspectives

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Abstract: Aging is associated with weakening of the circadian system. The circadian amplitude of most physiological variables is reduced, while the circadian phase becomes more labile and tends to occur earlier with advancing age. As the incidence of falls in older persons could follow circadian...

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Autores principales: Goswami, Nandu, Abulafia, Carolina Andrea, Vigo, Daniel Eduardo, Moser, Maximilian, Cornelissen, Germaine, Cardinali, Daniel Pedro
Formato: Artículo
Lenguaje:Inglés
Publicado: Dove Medical Press 2021
Materias:
ENVEJECIMIENTO
RITMO CIRCADIANO
MELATONINA
FISIOLOGIA
RIESGOS
Acceso en línea:https://repositorio.uca.edu.ar/handle/123456789/11547
Aporte de:
Repositorio Institucional de la Universidad Católica Argentina (UCA) de Universidad Católica Argentina
id I33-R139-123456789-11547
record_format dspace
spelling I33-R139-123456789-115472023-11-22T21:46:22Z Falls risk, circadian rhythms and melatonin : current perspectives Goswami, Nandu Abulafia, Carolina Andrea Vigo, Daniel Eduardo Moser, Maximilian Cornelissen, Germaine Cardinali, Daniel Pedro ENVEJECIMIENTO RITMO CIRCADIANO MELATONINA FISIOLOGIA RIESGOS Abstract: Aging is associated with weakening of the circadian system. The circadian amplitude of most physiological variables is reduced, while the circadian phase becomes more labile and tends to occur earlier with advancing age. As the incidence of falls in older persons could follow circadian variations, a better understanding of conditions in which falls occur can lead to the implementation of countermeasures (such as adjusting the scheduling of hospital staff, or changing the timing of anti-hypertensive medication if falls are related to undesirable circadian patterns of blood pressure and/or heart rate). This includes knowing the times of the day, days of the week, and times of the year when falls are more likely to occur at home or in the hospital. Additionally, the links between aging processes and factors associated with an increased risk of developing autonomic dysfunction are well established. A strong association between heart rate variability indexes and aging has been shown. Circadian rhythms of autonomous nervous system activity may play important role for maintenance of orthostatic tolerance. Whether one is concerned with disease prediction and prevention or maintenance of healthy aging, the study of circadian rhythms and the broader time structure underlying physiopathology is helpful in terms of screening, early diagnosis and prognosis, as well as the timely institution of prophylactic and/or palliative/ curative treatment. Timing the administration of such treatment as a function of circadian (and other) rhythms also could lead to reduction of falls in older persons. 2021-05-20T12:27:19Z 2021-05-20T12:27:19Z 2020 Artículo Goswami, N., Abulafia, C. A., Vigo, D. E., Moser, M., Cornelissen, G., Cardinali, D. P. Falls risk, circadian rhythms and melatonin : current perspectives [en línea]. Clinical Interventions in Aging. 2020, 15. Doi: 10.2147/CIA.S283342. Disponible en: https://repositorio.uca.edu.ar/handle/123456789/11547 1178-1998 (impreso) 1176-9092 (on line) https://repositorio.uca.edu.ar/handle/123456789/11547 10.2147/CIA.S283342 33204081 eng Acceso abierto http://creativecommons.org/licenses/by-nc-sa/4.0/ application/pdf Dove Medical Press Clinical Interventions in Aging. 2020, 15
institution Universidad Católica Argentina
institution_str I-33
repository_str R-139
collection Repositorio Institucional de la Universidad Católica Argentina (UCA)
language Inglés
topic ENVEJECIMIENTO
RITMO CIRCADIANO
MELATONINA
FISIOLOGIA
RIESGOS
spellingShingle ENVEJECIMIENTO
RITMO CIRCADIANO
MELATONINA
FISIOLOGIA
RIESGOS
Goswami, Nandu
Abulafia, Carolina Andrea
Vigo, Daniel Eduardo
Moser, Maximilian
Cornelissen, Germaine
Cardinali, Daniel Pedro
Falls risk, circadian rhythms and melatonin : current perspectives
topic_facet ENVEJECIMIENTO
RITMO CIRCADIANO
MELATONINA
FISIOLOGIA
RIESGOS
description Abstract: Aging is associated with weakening of the circadian system. The circadian amplitude of most physiological variables is reduced, while the circadian phase becomes more labile and tends to occur earlier with advancing age. As the incidence of falls in older persons could follow circadian variations, a better understanding of conditions in which falls occur can lead to the implementation of countermeasures (such as adjusting the scheduling of hospital staff, or changing the timing of anti-hypertensive medication if falls are related to undesirable circadian patterns of blood pressure and/or heart rate). This includes knowing the times of the day, days of the week, and times of the year when falls are more likely to occur at home or in the hospital. Additionally, the links between aging processes and factors associated with an increased risk of developing autonomic dysfunction are well established. A strong association between heart rate variability indexes and aging has been shown. Circadian rhythms of autonomous nervous system activity may play important role for maintenance of orthostatic tolerance. Whether one is concerned with disease prediction and prevention or maintenance of healthy aging, the study of circadian rhythms and the broader time structure underlying physiopathology is helpful in terms of screening, early diagnosis and prognosis, as well as the timely institution of prophylactic and/or palliative/ curative treatment. Timing the administration of such treatment as a function of circadian (and other) rhythms also could lead to reduction of falls in older persons.
format Artículo
author Goswami, Nandu
Abulafia, Carolina Andrea
Vigo, Daniel Eduardo
Moser, Maximilian
Cornelissen, Germaine
Cardinali, Daniel Pedro
author_facet Goswami, Nandu
Abulafia, Carolina Andrea
Vigo, Daniel Eduardo
Moser, Maximilian
Cornelissen, Germaine
Cardinali, Daniel Pedro
author_sort Goswami, Nandu
title Falls risk, circadian rhythms and melatonin : current perspectives
title_short Falls risk, circadian rhythms and melatonin : current perspectives
title_full Falls risk, circadian rhythms and melatonin : current perspectives
title_fullStr Falls risk, circadian rhythms and melatonin : current perspectives
title_full_unstemmed Falls risk, circadian rhythms and melatonin : current perspectives
title_sort falls risk, circadian rhythms and melatonin : current perspectives
publisher Dove Medical Press
publishDate 2021
url https://repositorio.uca.edu.ar/handle/123456789/11547
work_keys_str_mv AT goswaminandu fallsriskcircadianrhythmsandmelatonincurrentperspectives
AT abulafiacarolinaandrea fallsriskcircadianrhythmsandmelatonincurrentperspectives
AT vigodanieleduardo fallsriskcircadianrhythmsandmelatonincurrentperspectives
AT mosermaximilian fallsriskcircadianrhythmsandmelatonincurrentperspectives
AT cornelissengermaine fallsriskcircadianrhythmsandmelatonincurrentperspectives
AT cardinalidanielpedro fallsriskcircadianrhythmsandmelatonincurrentperspectives
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