Time‑dependent inhibition of Rac1 in the VTA enhances long‑term aversive memory : implications in active forgetting mechanisms

The fate of memories depends mainly on two opposing forces: the mechanisms required for the storage and maintenance of memory and the mechanisms underlying forgetting, being the latter much less understood. Here, we show the effect of inhibiting the small Rho GTPase Rac1 on the fate of inhibitory av...

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Autores principales: Dalto, Juliana F., Medina, Jorge H.
Formato: Artículo de publicación periódica
Lenguaje:Inglés
Publicado: Scientific Reports 2024
Materias:
MEMORIA
MEMORIA A LARGO PLAZO
MEMORY
INVESTIGACIÓN
Acceso en línea:https://ri.itba.edu.ar/handle/20.500.14769/4257
https://doi.org/10.1038/s41598-023-40434-9
Aporte de:
Repositorio Institucional Instituto Tecnológico de Buenos Aires (ITBA) de Instituto Tecnológico de Buenos Aires (ITBA)
id I32-R138-20.500.14769-4257
record_format dspace
spelling I32-R138-20.500.14769-42572026-01-15T15:30:48Z Time‑dependent inhibition of Rac1 in the VTA enhances long‑term aversive memory : implications in active forgetting mechanisms Dalto, Juliana F. Medina, Jorge H. MEMORIA MEMORIA A LARGO PLAZO MEMORY INVESTIGACIÓN The fate of memories depends mainly on two opposing forces: the mechanisms required for the storage and maintenance of memory and the mechanisms underlying forgetting, being the latter much less understood. Here, we show the effect of inhibiting the small Rho GTPase Rac1 on the fate of inhibitory avoidance memory in male rats. The immediate post-training micro-infusion of the specific Rac1 inhibitor NSC23766 (150 ng/0.5 µl/ side) into the ventral tegmental area (VTA) enhanced long-term memory at 1, 7, and 14 days after a single training. Additionally, an opposed effect occurred when the inhibitor was infused at 12 h after training while no effect was observed immediately after testing animals at 1 day. Control experiments ruled out the possibility that post-training memory enhancement was due to facilitation of memory formation since no effect was found when animals were tested at 1 h after acquisition and no memory enhancement was observed after the formation of a weak memory. Immediate post-training micro-infusion of Rac1 inhibitor into the dorsal hippocampus, or the amygdala did not affect memory. Our findings support the idea of a Rac1-dependent time-specific active forgetting mechanism in the VTA controlling the strength of a long-term aversive memory. Agencia Nacional de Promoción Científica y Tecnológica, Argentina. Universidad de Buenos Aires, Argentina. 2024-01-02T18:09:23Z 2024-01-02T18:09:23Z 2023-08-19 Artículo de publicación periódica Dalto, J.F., Medina, J.H. Time-dependent inhibition of Rac1 in the VTA enhances long-term aversive memory: implications in active forgetting mechanisms. Sci Rep 13, 13507 (2023). https://doi.org/10.1038/s41598-023-40434-9 https://ri.itba.edu.ar/handle/20.500.14769/4257 https://doi.org/10.1038/s41598-023-40434-9 en application/pdf Scientific Reports
institution Instituto Tecnológico de Buenos Aires (ITBA)
institution_str I-32
repository_str R-138
collection Repositorio Institucional Instituto Tecnológico de Buenos Aires (ITBA)
language Inglés
topic MEMORIA
MEMORIA A LARGO PLAZO
MEMORY
INVESTIGACIÓN
spellingShingle MEMORIA
MEMORIA A LARGO PLAZO
MEMORY
INVESTIGACIÓN
Dalto, Juliana F.
Medina, Jorge H.
Time‑dependent inhibition of Rac1 in the VTA enhances long‑term aversive memory : implications in active forgetting mechanisms
topic_facet MEMORIA
MEMORIA A LARGO PLAZO
MEMORY
INVESTIGACIÓN
description The fate of memories depends mainly on two opposing forces: the mechanisms required for the storage and maintenance of memory and the mechanisms underlying forgetting, being the latter much less understood. Here, we show the effect of inhibiting the small Rho GTPase Rac1 on the fate of inhibitory avoidance memory in male rats. The immediate post-training micro-infusion of the specific Rac1 inhibitor NSC23766 (150 ng/0.5 µl/ side) into the ventral tegmental area (VTA) enhanced long-term memory at 1, 7, and 14 days after a single training. Additionally, an opposed effect occurred when the inhibitor was infused at 12 h after training while no effect was observed immediately after testing animals at 1 day. Control experiments ruled out the possibility that post-training memory enhancement was due to facilitation of memory formation since no effect was found when animals were tested at 1 h after acquisition and no memory enhancement was observed after the formation of a weak memory. Immediate post-training micro-infusion of Rac1 inhibitor into the dorsal hippocampus, or the amygdala did not affect memory. Our findings support the idea of a Rac1-dependent time-specific active forgetting mechanism in the VTA controlling the strength of a long-term aversive memory.
format Artículo de publicación periódica
author Dalto, Juliana F.
Medina, Jorge H.
author_facet Dalto, Juliana F.
Medina, Jorge H.
author_sort Dalto, Juliana F.
title Time‑dependent inhibition of Rac1 in the VTA enhances long‑term aversive memory : implications in active forgetting mechanisms
title_short Time‑dependent inhibition of Rac1 in the VTA enhances long‑term aversive memory : implications in active forgetting mechanisms
title_full Time‑dependent inhibition of Rac1 in the VTA enhances long‑term aversive memory : implications in active forgetting mechanisms
title_fullStr Time‑dependent inhibition of Rac1 in the VTA enhances long‑term aversive memory : implications in active forgetting mechanisms
title_full_unstemmed Time‑dependent inhibition of Rac1 in the VTA enhances long‑term aversive memory : implications in active forgetting mechanisms
title_sort time‑dependent inhibition of rac1 in the vta enhances long‑term aversive memory : implications in active forgetting mechanisms
publisher Scientific Reports
publishDate 2024
url https://ri.itba.edu.ar/handle/20.500.14769/4257
https://doi.org/10.1038/s41598-023-40434-9
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AT medinajorgeh timedependentinhibitionofrac1inthevtaenhanceslongtermaversivememoryimplicationsinactiveforgettingmechanisms
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