Towards an experimental control of neural activity: The Wilson-Cowan model

The prospect of modifying neural activity in a principled way, could facilitate the understanding of brain functions and the development of medical treatments. To predict the dynamics that underlie the different brain activities, several neurobiological models have been proposed, either focusing on...

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Autores principales: Martinez, Sebastián, Sánchez-Peña, Ricardo, Belluscio, Mariano, Piriz, Joaquín, Garcia-Violini, Demián
Formato: Artículo de Publicación Periódica
Lenguaje:Inglés
Publicado: IFAC-PapersOnLine 2023
Materias:
SISTEMAS DE CONTROL
MODELO NEURONAL
OPTOGENETICA
Acceso en línea:https://ri.itba.edu.ar/handle/123456789/4195
Aporte de:
Repositorio Institucional Instituto Tecnológico de Buenos Aires (ITBA) de Instituto Tecnológico de Buenos Aires (ITBA)
id I32-R138-123456789-4195
record_format dspace
spelling I32-R138-123456789-41952023-06-27T03:00:57Z Towards an experimental control of neural activity: The Wilson-Cowan model Martinez, Sebastián Sánchez-Peña, Ricardo Belluscio, Mariano Piriz, Joaquín Garcia-Violini, Demián SISTEMAS DE CONTROL MODELO NEURONAL OPTOGENETICA The prospect of modifying neural activity in a principled way, could facilitate the understanding of brain functions and the development of medical treatments. To predict the dynamics that underlie the different brain activities, several neurobiological models have been proposed, either focusing on individual cells or whole populations. In this context, control systems are a powerful tool to provide a correct articulation between inputs, i.e. neural stimuli, and observables, i.e. system outcomes. Based on well-established neurobiological hypotheses, this study presents a control framework to regulate a neural-mass activity, with potential uses for pattern tracking, such as, rhythm evoking and phase synchronisation. Being these mechanisms closely connected with real brain computations, this study is carried out using a meaningful perspective in terms of biological interpretation. To this end, the Wilson-Cowan model is used, where the input stimuli is elicited through light signals applied to genetically modified neurons that express light-gated actuators. Thus, this study states a crucial proof of concept towards a future experimental application of the control framework for neurobiological systems. 2023-06-26T14:02:02Z 2023-06-26T14:02:02Z 2022 Artículo de Publicación Periódica Martinez, S. et al. (2022) Towards an experimental control of neural activity: The Wilson-Cowan model. [En linea]. IFAC-PapersOnLine, 55 (40), 223-228. Disponible en: https://ri.itba.edu.ar/handle/123456789/4195 https://ri.itba.edu.ar/handle/123456789/4195 en application/pdf IFAC-PapersOnLine
institution Instituto Tecnológico de Buenos Aires (ITBA)
institution_str I-32
repository_str R-138
collection Repositorio Institucional Instituto Tecnológico de Buenos Aires (ITBA)
language Inglés
topic SISTEMAS DE CONTROL
MODELO NEURONAL
OPTOGENETICA
spellingShingle SISTEMAS DE CONTROL
MODELO NEURONAL
OPTOGENETICA
Martinez, Sebastián
Sánchez-Peña, Ricardo
Belluscio, Mariano
Piriz, Joaquín
Garcia-Violini, Demián
Towards an experimental control of neural activity: The Wilson-Cowan model
topic_facet SISTEMAS DE CONTROL
MODELO NEURONAL
OPTOGENETICA
description The prospect of modifying neural activity in a principled way, could facilitate the understanding of brain functions and the development of medical treatments. To predict the dynamics that underlie the different brain activities, several neurobiological models have been proposed, either focusing on individual cells or whole populations. In this context, control systems are a powerful tool to provide a correct articulation between inputs, i.e. neural stimuli, and observables, i.e. system outcomes. Based on well-established neurobiological hypotheses, this study presents a control framework to regulate a neural-mass activity, with potential uses for pattern tracking, such as, rhythm evoking and phase synchronisation. Being these mechanisms closely connected with real brain computations, this study is carried out using a meaningful perspective in terms of biological interpretation. To this end, the Wilson-Cowan model is used, where the input stimuli is elicited through light signals applied to genetically modified neurons that express light-gated actuators. Thus, this study states a crucial proof of concept towards a future experimental application of the control framework for neurobiological systems.
format Artículo de Publicación Periódica
author Martinez, Sebastián
Sánchez-Peña, Ricardo
Belluscio, Mariano
Piriz, Joaquín
Garcia-Violini, Demián
author_facet Martinez, Sebastián
Sánchez-Peña, Ricardo
Belluscio, Mariano
Piriz, Joaquín
Garcia-Violini, Demián
author_sort Martinez, Sebastián
title Towards an experimental control of neural activity: The Wilson-Cowan model
title_short Towards an experimental control of neural activity: The Wilson-Cowan model
title_full Towards an experimental control of neural activity: The Wilson-Cowan model
title_fullStr Towards an experimental control of neural activity: The Wilson-Cowan model
title_full_unstemmed Towards an experimental control of neural activity: The Wilson-Cowan model
title_sort towards an experimental control of neural activity: the wilson-cowan model
publisher IFAC-PapersOnLine
publishDate 2023
url https://ri.itba.edu.ar/handle/123456789/4195
work_keys_str_mv AT martinezsebastian towardsanexperimentalcontrolofneuralactivitythewilsoncowanmodel
AT sanchezpenaricardo towardsanexperimentalcontrolofneuralactivitythewilsoncowanmodel
AT bellusciomariano towardsanexperimentalcontrolofneuralactivitythewilsoncowanmodel
AT pirizjoaquin towardsanexperimentalcontrolofneuralactivitythewilsoncowanmodel
AT garciaviolinidemian towardsanexperimentalcontrolofneuralactivitythewilsoncowanmodel
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