Carbohydrate-derived polytriazole nanoparticles enhance the antiInflammatory activity of cilostazol

"Poly(amide-triazole) and poly(ester-triazole) synthesized from d-galactose as a renewable resource were applied for the synthesis of nanoparticles (NPs) by the emulsification/solvent evaporation method. The NPs were characterized as stable, spherical particles, and none of their components, in...

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Autores principales: Rivas, M. Verónica, Musikant, Daniel, Díaz Peña, Rocío, Álvarez, Daniela, Pelazzo, Luciana, Rossi, Ezequiel, Martínez, Karina D., Errea, María Inés, Pérez, Óscar E., Varela, Óscar, Kolender, Adriana K.
Formato: Artículo de Publicación Periódica publishedVersion
Lenguaje:Inglés
Publicado: 2023
Materias:
NANOBIOINGENIERA
NANOPARTICULAS
CARBOHIDRATOS
Acceso en línea:https://ri.itba.edu.ar/handle/123456789/4142
Aporte de:
Repositorio Institucional Instituto Tecnológico de Buenos Aires (ITBA) de Instituto Tecnológico de Buenos Aires (ITBA)
id I32-R138-123456789-4142
record_format dspace
spelling I32-R138-123456789-41422023-01-12T03:00:57Z Carbohydrate-derived polytriazole nanoparticles enhance the antiInflammatory activity of cilostazol Rivas, M. Verónica Musikant, Daniel Díaz Peña, Rocío Álvarez, Daniela Pelazzo, Luciana Rossi, Ezequiel Martínez, Karina D. Errea, María Inés Pérez, Óscar E. Varela, Óscar Kolender, Adriana K. NANOBIOINGENIERA NANOPARTICULAS CARBOHIDRATOS "Poly(amide-triazole) and poly(ester-triazole) synthesized from d-galactose as a renewable resource were applied for the synthesis of nanoparticles (NPs) by the emulsification/solvent evaporation method. The NPs were characterized as stable, spherical particles, and none of their components, including the stabilizer poly(vinyl alcohol), were cytotoxic for normal rat kidney cells. These NPs proved to be useful for the efficient encapsulation of cilostazol (CLZ), an antiplatelet and vasodilator drug currently used for the treatment of intermittent claudication, which is associated with undesired side-effects. In this context, the nanoencapsulation of CLZ was expected to improve its therapeutic administration. The carbohydrate-derived polymeric NPs were designed taking into account that the triazole rings of the polymer backbone could have attractive interactions with the tetrazole ring of CLZ. The activity of the nanoencapsulated CLZ was measured using a matrix metalloproteinase model in a lipopolysaccharide-induced inflammation system. Interestingly, the encapsulated drug exhibited enhanced anti-inflammatory activity in comparison with the free drug. The results are very promising since the stable, noncytotoxic NP systems efficiently reduced the inflammation response at low CLZ doses. In summary, the NPs were obtained through an innovative methodology that combines a carbohydrate-derived synthetic polymer, designed to interact with the drug, ease of preparation, adequate biological performance, and environmentally friendly production." 2023-01-11T16:16:00Z 2023-01-11T16:16:00Z 2022-11-30 Artículo de Publicación Periódica info:eu-repo/semantics/publishedVersion 2470-1343 https://ri.itba.edu.ar/handle/123456789/4142 en info:eu-repo/semantics/reference/doi/10.1021/acsomega.2c02969 info:eu-repo/grantAgreement/CONICET/PIP/11220150100443/AR. Ciudad Autónoma de Buenos Aires info:eu-repo/grantAgreement/UBA/UBACyT/20020170100403BA/AR. Ciudad Autónoma de Buenos Aires https://creativecommons.org/licenses/by-nc-nd/4.0/ application/pdf
institution Instituto Tecnológico de Buenos Aires (ITBA)
institution_str I-32
repository_str R-138
collection Repositorio Institucional Instituto Tecnológico de Buenos Aires (ITBA)
language Inglés
topic NANOBIOINGENIERA
NANOPARTICULAS
CARBOHIDRATOS
spellingShingle NANOBIOINGENIERA
NANOPARTICULAS
CARBOHIDRATOS
Rivas, M. Verónica
Musikant, Daniel
Díaz Peña, Rocío
Álvarez, Daniela
Pelazzo, Luciana
Rossi, Ezequiel
Martínez, Karina D.
Errea, María Inés
Pérez, Óscar E.
Varela, Óscar
Kolender, Adriana K.
Carbohydrate-derived polytriazole nanoparticles enhance the antiInflammatory activity of cilostazol
topic_facet NANOBIOINGENIERA
NANOPARTICULAS
CARBOHIDRATOS
description "Poly(amide-triazole) and poly(ester-triazole) synthesized from d-galactose as a renewable resource were applied for the synthesis of nanoparticles (NPs) by the emulsification/solvent evaporation method. The NPs were characterized as stable, spherical particles, and none of their components, including the stabilizer poly(vinyl alcohol), were cytotoxic for normal rat kidney cells. These NPs proved to be useful for the efficient encapsulation of cilostazol (CLZ), an antiplatelet and vasodilator drug currently used for the treatment of intermittent claudication, which is associated with undesired side-effects. In this context, the nanoencapsulation of CLZ was expected to improve its therapeutic administration. The carbohydrate-derived polymeric NPs were designed taking into account that the triazole rings of the polymer backbone could have attractive interactions with the tetrazole ring of CLZ. The activity of the nanoencapsulated CLZ was measured using a matrix metalloproteinase model in a lipopolysaccharide-induced inflammation system. Interestingly, the encapsulated drug exhibited enhanced anti-inflammatory activity in comparison with the free drug. The results are very promising since the stable, noncytotoxic NP systems efficiently reduced the inflammation response at low CLZ doses. In summary, the NPs were obtained through an innovative methodology that combines a carbohydrate-derived synthetic polymer, designed to interact with the drug, ease of preparation, adequate biological performance, and environmentally friendly production."
format Artículo de Publicación Periódica
publishedVersion
author Rivas, M. Verónica
Musikant, Daniel
Díaz Peña, Rocío
Álvarez, Daniela
Pelazzo, Luciana
Rossi, Ezequiel
Martínez, Karina D.
Errea, María Inés
Pérez, Óscar E.
Varela, Óscar
Kolender, Adriana K.
author_facet Rivas, M. Verónica
Musikant, Daniel
Díaz Peña, Rocío
Álvarez, Daniela
Pelazzo, Luciana
Rossi, Ezequiel
Martínez, Karina D.
Errea, María Inés
Pérez, Óscar E.
Varela, Óscar
Kolender, Adriana K.
author_sort Rivas, M. Verónica
title Carbohydrate-derived polytriazole nanoparticles enhance the antiInflammatory activity of cilostazol
title_short Carbohydrate-derived polytriazole nanoparticles enhance the antiInflammatory activity of cilostazol
title_full Carbohydrate-derived polytriazole nanoparticles enhance the antiInflammatory activity of cilostazol
title_fullStr Carbohydrate-derived polytriazole nanoparticles enhance the antiInflammatory activity of cilostazol
title_full_unstemmed Carbohydrate-derived polytriazole nanoparticles enhance the antiInflammatory activity of cilostazol
title_sort carbohydrate-derived polytriazole nanoparticles enhance the antiinflammatory activity of cilostazol
publishDate 2023
url https://ri.itba.edu.ar/handle/123456789/4142
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