Imidazo[2,1-b]thiazole carbohydrate derivatives: synthesis and antiviral activity against Junin virus, agent of Argentine hemorrhagic fever
"Herein, we describe the syntheses of 3,5-disubstituted imidazo[2,1-b]thiazole. The cyclization step was performed in two different conditions by using either thermal or microwave heating. Comparing the results of both methodologies, we found that the microwave assistance is an improved alterna...
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| Formato: | Artículos de Publicaciones Periódicas acceptedVersion |
| Lenguaje: | Inglés |
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2022
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| Acceso en línea: | https://ri.itba.edu.ar/handle/123456789/4038 |
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I32-R138-123456789-4038 |
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I32-R138-123456789-40382022-12-07T13:06:43Z Imidazo[2,1-b]thiazole carbohydrate derivatives: synthesis and antiviral activity against Junin virus, agent of Argentine hemorrhagic fever Barradas, José Sebastián Errea, María Inés D´Accorso, Norma B. Sepúlveda, Claudia Soledad Damonte, Elsa Beatriz CARBOHIDRATOS RADIACION MICROONDAS VIRUS "Herein, we describe the syntheses of 3,5-disubstituted imidazo[2,1-b]thiazole. The cyclization step was performed in two different conditions by using either thermal or microwave heating. Comparing the results of both methodologies, we found that the microwave assistance is an improved alternative to obtain this family of heterocyclic compound. Compounds were first evaluated for cytotoxicity in Vero cells by MTT method and then, the antiviral activity was assayed by a virus yield inhibition assay in the range of concentrations lower than the corresponding CC50, using JUNV strain IV4454 as the model system. The most active compounds (3 and 4), showed a level of antiviral activity against JUNV in monkey Vero cells better than the reference substance ribavirin. Then, they are promising lead compound for further analysis and characterization to establish their therapeutic potential against hemorrhagic fever viruses." 2022-11-25T15:25:33Z 2022-11-25T15:25:33Z 2011-01 Artículos de Publicaciones Periódicas info:eu-repo/semantics/acceptedVersion 0223-5234 https://ri.itba.edu.ar/handle/123456789/4038 en info:eu-repo/semantics/altIdentifier/doi/10.1016/j.ejmech.2010.11.012 info:eu-repo/semantics/embargoedAccess application/pdf |
| institution |
Instituto Tecnológico de Buenos Aires (ITBA) |
| institution_str |
I-32 |
| repository_str |
R-138 |
| collection |
Repositorio Institucional Instituto Tecnológico de Buenos Aires (ITBA) |
| language |
Inglés |
| topic |
CARBOHIDRATOS RADIACION MICROONDAS VIRUS |
| spellingShingle |
CARBOHIDRATOS RADIACION MICROONDAS VIRUS Barradas, José Sebastián Errea, María Inés D´Accorso, Norma B. Sepúlveda, Claudia Soledad Damonte, Elsa Beatriz Imidazo[2,1-b]thiazole carbohydrate derivatives: synthesis and antiviral activity against Junin virus, agent of Argentine hemorrhagic fever |
| topic_facet |
CARBOHIDRATOS RADIACION MICROONDAS VIRUS |
| description |
"Herein, we describe the syntheses of 3,5-disubstituted imidazo[2,1-b]thiazole. The cyclization step was performed in two different conditions by using either thermal or microwave heating. Comparing the results of both methodologies, we found that the microwave assistance is an improved alternative to obtain this family of heterocyclic compound. Compounds were first evaluated for cytotoxicity in Vero cells by MTT method and then, the antiviral activity was assayed by a virus yield inhibition assay in the range of concentrations lower than the corresponding CC50, using JUNV strain IV4454 as the model system. The most active compounds (3 and 4), showed a level of antiviral activity against JUNV in monkey Vero cells better than the reference substance ribavirin. Then, they are promising lead compound for further analysis and characterization to establish their therapeutic potential against hemorrhagic fever viruses." |
| format |
Artículos de Publicaciones Periódicas acceptedVersion |
| author |
Barradas, José Sebastián Errea, María Inés D´Accorso, Norma B. Sepúlveda, Claudia Soledad Damonte, Elsa Beatriz |
| author_facet |
Barradas, José Sebastián Errea, María Inés D´Accorso, Norma B. Sepúlveda, Claudia Soledad Damonte, Elsa Beatriz |
| author_sort |
Barradas, José Sebastián |
| title |
Imidazo[2,1-b]thiazole carbohydrate derivatives: synthesis and antiviral activity against Junin virus, agent of Argentine hemorrhagic fever |
| title_short |
Imidazo[2,1-b]thiazole carbohydrate derivatives: synthesis and antiviral activity against Junin virus, agent of Argentine hemorrhagic fever |
| title_full |
Imidazo[2,1-b]thiazole carbohydrate derivatives: synthesis and antiviral activity against Junin virus, agent of Argentine hemorrhagic fever |
| title_fullStr |
Imidazo[2,1-b]thiazole carbohydrate derivatives: synthesis and antiviral activity against Junin virus, agent of Argentine hemorrhagic fever |
| title_full_unstemmed |
Imidazo[2,1-b]thiazole carbohydrate derivatives: synthesis and antiviral activity against Junin virus, agent of Argentine hemorrhagic fever |
| title_sort |
imidazo[2,1-b]thiazole carbohydrate derivatives: synthesis and antiviral activity against junin virus, agent of argentine hemorrhagic fever |
| publishDate |
2022 |
| url |
https://ri.itba.edu.ar/handle/123456789/4038 |
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