Homogeneous hydrolytic degradation of poly(lactic-co-glycolic acid) microspheres: Mathematical modeling

"The homogeneous hydrolytic degradation of poly(lactic-co-glycolic acid) (PLGA) microspheres was investigated. A mathematical model was developed that estimates the evolutions of ester bonds concentrations and average molecular weights along the degradation process. The model is based on a deta...

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Autores principales: Busatto, Carlos, Berkenwald, Emilio, Nicolás, Mariano, Casis, Natalia, Luna, Julio, Estenoz, Diana
Formato: Artículos de Publicaciones Periódicas acceptedVersion
Lenguaje:Inglés
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Acceso en línea:http://ri.itba.edu.ar/handle/123456789/3792
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Repositorio Institucional Instituto Tecnológico de Buenos Aires (ITBA) de Instituto Tecnológico de Buenos Aires (ITBA)
id I32-R138-123456789-3792
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spelling I32-R138-123456789-37922022-12-07T13:06:38Z Homogeneous hydrolytic degradation of poly(lactic-co-glycolic acid) microspheres: Mathematical modeling Busatto, Carlos Berkenwald, Emilio Nicolás, Mariano Casis, Natalia Luna, Julio Estenoz, Diana ESTERES "The homogeneous hydrolytic degradation of poly(lactic-co-glycolic acid) (PLGA) microspheres was investigated. A mathematical model was developed that estimates the evolutions of ester bonds concentrations and average molecular weights along the degradation process. The model is based on a detailed kinetic mechanism that includes the hydrolysis of the different types of ester bonds by random chain scission and considers the effect of polymer chemical composition and molecular structure. Novel and published experimental data were used to adjust and validate the model. The experimental work consisted of homogeneous hydrolytic degradation of PLGA microspheres. The predictions are in very good agreement with the experimental results." info:eu-repo/date/embargoEnd/2018-03-01 2022-04-18T20:25:54Z 2022-04-18T20:25:54Z 2015-12 Artículos de Publicaciones Periódicas info:eu-repo/semantics/acceptedVersion 0141-3910 http://ri.itba.edu.ar/handle/123456789/3792 en info:eu-repo/semantics/altIdentifier/doi/ 10.1016/j.polymdegradstab.2015.12.018 info:eu-repo/grantAgreement/CONICET/PIP/848/AR. Ciudad Autónoma de Buenos Aires info:eu-repo/grantAgreement/ANPCyT/PICT/2011-1254/AR. Ciudad Autónoma de Buenos Aires info:eu-repo/grantAgreement/UNL/UNLCyT/2011-419/AR. Santa Fe. Santa Fe application/pdf
institution Instituto Tecnológico de Buenos Aires (ITBA)
institution_str I-32
repository_str R-138
collection Repositorio Institucional Instituto Tecnológico de Buenos Aires (ITBA)
language Inglés
topic ESTERES
spellingShingle ESTERES
Busatto, Carlos
Berkenwald, Emilio
Nicolás, Mariano
Casis, Natalia
Luna, Julio
Estenoz, Diana
Homogeneous hydrolytic degradation of poly(lactic-co-glycolic acid) microspheres: Mathematical modeling
topic_facet ESTERES
description "The homogeneous hydrolytic degradation of poly(lactic-co-glycolic acid) (PLGA) microspheres was investigated. A mathematical model was developed that estimates the evolutions of ester bonds concentrations and average molecular weights along the degradation process. The model is based on a detailed kinetic mechanism that includes the hydrolysis of the different types of ester bonds by random chain scission and considers the effect of polymer chemical composition and molecular structure. Novel and published experimental data were used to adjust and validate the model. The experimental work consisted of homogeneous hydrolytic degradation of PLGA microspheres. The predictions are in very good agreement with the experimental results."
format Artículos de Publicaciones Periódicas
acceptedVersion
author Busatto, Carlos
Berkenwald, Emilio
Nicolás, Mariano
Casis, Natalia
Luna, Julio
Estenoz, Diana
author_facet Busatto, Carlos
Berkenwald, Emilio
Nicolás, Mariano
Casis, Natalia
Luna, Julio
Estenoz, Diana
author_sort Busatto, Carlos
title Homogeneous hydrolytic degradation of poly(lactic-co-glycolic acid) microspheres: Mathematical modeling
title_short Homogeneous hydrolytic degradation of poly(lactic-co-glycolic acid) microspheres: Mathematical modeling
title_full Homogeneous hydrolytic degradation of poly(lactic-co-glycolic acid) microspheres: Mathematical modeling
title_fullStr Homogeneous hydrolytic degradation of poly(lactic-co-glycolic acid) microspheres: Mathematical modeling
title_full_unstemmed Homogeneous hydrolytic degradation of poly(lactic-co-glycolic acid) microspheres: Mathematical modeling
title_sort homogeneous hydrolytic degradation of poly(lactic-co-glycolic acid) microspheres: mathematical modeling
publishDate info
url http://ri.itba.edu.ar/handle/123456789/3792
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AT nicolasmariano homogeneoushydrolyticdegradationofpolylacticcoglycolicacidmicrospheresmathematicalmodeling
AT casisnatalia homogeneoushydrolyticdegradationofpolylacticcoglycolicacidmicrospheresmathematicalmodeling
AT lunajulio homogeneoushydrolyticdegradationofpolylacticcoglycolicacidmicrospheresmathematicalmodeling
AT estenozdiana homogeneoushydrolyticdegradationofpolylacticcoglycolicacidmicrospheresmathematicalmodeling
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