Functional connectivity of anterior retrosplenial cortex in object recognition memory

"Recognition memory can rely on three components: “what”, “where” and “when”. Recently we demonstrated that the anterior retrosplenial cortex (aRSC), like the perirhinal cortex (PRH) and unlike the hippocampus (HP), is required for consolidation of the “what” component. Here, we aimed at studyi...

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Autores principales: de Landeta, Ana Belén, Pereyra, Magdalena, Miranda, Magdalena, Bekinschtein, Pedro, Medina, Jorge Horacio, Katche, Cynthia
Formato: Artículos de Publicaciones Periódicas publishedVersion
Lenguaje:Inglés
Publicado: info
Materias:
CONSOLIDACION DE LA MEMORIA
MEMORIA
GIRO DEL CINGULO
MUSCIMOL
Acceso en línea:http://ri.itba.edu.ar/handle/123456789/3777
Aporte de:
Repositorio Institucional Instituto Tecnológico de Buenos Aires (ITBA) de Instituto Tecnológico de Buenos Aires (ITBA)
id I32-R138-123456789-3777
record_format dspace
spelling I32-R138-123456789-37772023-01-13T12:56:29Z Functional connectivity of anterior retrosplenial cortex in object recognition memory de Landeta, Ana Belén Pereyra, Magdalena Miranda, Magdalena Bekinschtein, Pedro Medina, Jorge Horacio Katche, Cynthia CONSOLIDACION DE LA MEMORIA MEMORIA GIRO DEL CINGULO MUSCIMOL "Recognition memory can rely on three components: “what”, “where” and “when”. Recently we demonstrated that the anterior retrosplenial cortex (aRSC), like the perirhinal cortex (PRH) and unlike the hippocampus (HP), is required for consolidation of the “what” component. Here, we aimed at studying which brain structures interact with the aRSC to process object recognition (OR) memory in rats. We studied the interaction of six brain structures that are connected to the aRSC during OR memory processing: PRH, medial prefrontal cortex (mPFC), anteromedial thalamic nuclei (AM), medial entorhinal cortex (MEC), anterior cingulate cortex (ACC) and the dorsal HP (dHP). We previously described the role of the PRH and dHP, so we first studied the participation of the mPFC, AM, MEC and ACC in OR memory consolidation by bilateral microinfusions of the GABAA receptor agonist muscimol. We observed an impairment in OR long-term memory (LTM) when inactivating the mPFC, the AM and the MEC, but not the ACC. Then, we studied the functional connections by unilateral inactivation of the aRSC and each one of the six structures in the same (ipsilateral) or the opposite (contralateral) hemisphere. Our results showed an amnesic LTM effect in rats with ipsilateral inactivations of aRSC-PRH, aRSC-mPFC, aRSC-AM, or aRSC-MEC. On the other hand, we observed memory impairment when aRSC-ACC were inactivated in opposite hemispheres, and no effect when the aRSC-dHP connection was inactivated. Thus, our ipsilateral inactivation findings reveal that the aRSC and, at least one brain region required in OR LTM processing are essential to consolidate OR memory. In conclusion, our results show that several cortico-cortical and cortico thalamic pathways are important for OR memory consolidation." info:eu-repo/date/embargoEnd/2023-04-22 2022-04-13T19:55:25Z 2022-04-13T19:55:25Z 2021 Artículos de Publicaciones Periódicas info:eu-repo/semantics/publishedVersion 1074-7427 http://ri.itba.edu.ar/handle/123456789/3777 en info:eurepo/semantics/altIdentifier/10.1016/j.nlm.2021.107544 application/pdf
institution Instituto Tecnológico de Buenos Aires (ITBA)
institution_str I-32
repository_str R-138
collection Repositorio Institucional Instituto Tecnológico de Buenos Aires (ITBA)
language Inglés
topic CONSOLIDACION DE LA MEMORIA
MEMORIA
GIRO DEL CINGULO
MUSCIMOL
spellingShingle CONSOLIDACION DE LA MEMORIA
MEMORIA
GIRO DEL CINGULO
MUSCIMOL
de Landeta, Ana Belén
Pereyra, Magdalena
Miranda, Magdalena
Bekinschtein, Pedro
Medina, Jorge Horacio
Katche, Cynthia
Functional connectivity of anterior retrosplenial cortex in object recognition memory
topic_facet CONSOLIDACION DE LA MEMORIA
MEMORIA
GIRO DEL CINGULO
MUSCIMOL
description "Recognition memory can rely on three components: “what”, “where” and “when”. Recently we demonstrated that the anterior retrosplenial cortex (aRSC), like the perirhinal cortex (PRH) and unlike the hippocampus (HP), is required for consolidation of the “what” component. Here, we aimed at studying which brain structures interact with the aRSC to process object recognition (OR) memory in rats. We studied the interaction of six brain structures that are connected to the aRSC during OR memory processing: PRH, medial prefrontal cortex (mPFC), anteromedial thalamic nuclei (AM), medial entorhinal cortex (MEC), anterior cingulate cortex (ACC) and the dorsal HP (dHP). We previously described the role of the PRH and dHP, so we first studied the participation of the mPFC, AM, MEC and ACC in OR memory consolidation by bilateral microinfusions of the GABAA receptor agonist muscimol. We observed an impairment in OR long-term memory (LTM) when inactivating the mPFC, the AM and the MEC, but not the ACC. Then, we studied the functional connections by unilateral inactivation of the aRSC and each one of the six structures in the same (ipsilateral) or the opposite (contralateral) hemisphere. Our results showed an amnesic LTM effect in rats with ipsilateral inactivations of aRSC-PRH, aRSC-mPFC, aRSC-AM, or aRSC-MEC. On the other hand, we observed memory impairment when aRSC-ACC were inactivated in opposite hemispheres, and no effect when the aRSC-dHP connection was inactivated. Thus, our ipsilateral inactivation findings reveal that the aRSC and, at least one brain region required in OR LTM processing are essential to consolidate OR memory. In conclusion, our results show that several cortico-cortical and cortico thalamic pathways are important for OR memory consolidation."
format Artículos de Publicaciones Periódicas
publishedVersion
author de Landeta, Ana Belén
Pereyra, Magdalena
Miranda, Magdalena
Bekinschtein, Pedro
Medina, Jorge Horacio
Katche, Cynthia
author_facet de Landeta, Ana Belén
Pereyra, Magdalena
Miranda, Magdalena
Bekinschtein, Pedro
Medina, Jorge Horacio
Katche, Cynthia
author_sort de Landeta, Ana Belén
title Functional connectivity of anterior retrosplenial cortex in object recognition memory
title_short Functional connectivity of anterior retrosplenial cortex in object recognition memory
title_full Functional connectivity of anterior retrosplenial cortex in object recognition memory
title_fullStr Functional connectivity of anterior retrosplenial cortex in object recognition memory
title_full_unstemmed Functional connectivity of anterior retrosplenial cortex in object recognition memory
title_sort functional connectivity of anterior retrosplenial cortex in object recognition memory
publishDate info
url http://ri.itba.edu.ar/handle/123456789/3777
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AT medinajorgehoracio functionalconnectivityofanteriorretrosplenialcortexinobjectrecognitionmemory
AT katchecynthia functionalconnectivityofanteriorretrosplenialcortexinobjectrecognitionmemory
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