Medial prefrontal cortical control of reward- and aversion-based behavioral output: bottom-up modulation

"How does the brain guide our actions? This is a complex issue, where the medial prefrontal cortex (mPFC) plays a crucial role. The mPFC is essential for cognitive flexibility and decision making. These functions are related to reward- and aversionbased learning, which ultimately drive behavior...

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Detalles Bibliográficos
Autores principales: Pastor, Verónica, Medina, Jorge Horacio
Formato: Artículos de Publicaciones Periódicas publishedVersion
Lenguaje:Inglés
Publicado: info
Materias:
ENFERMEDADES MENTALES
CONDUCTA
CORTEZA PREFRONTAL
NEURONAS
SEROTONINA
NORADRENALINA
DOPAMINA
ACETILCOLINA
Acceso en línea:http://ri.itba.edu.ar/handle/123456789/3450
Aporte de:
Repositorio Institucional Instituto Tecnológico de Buenos Aires (ITBA) de Instituto Tecnológico de Buenos Aires (ITBA)
id I32-R138-123456789-3450
record_format dspace
spelling I32-R138-123456789-34502022-12-07T13:06:48Z Medial prefrontal cortical control of reward- and aversion-based behavioral output: bottom-up modulation Pastor, Verónica Medina, Jorge Horacio ENFERMEDADES MENTALES CONDUCTA CORTEZA PREFRONTAL NEURONAS SEROTONINA NORADRENALINA DOPAMINA ACETILCOLINA "How does the brain guide our actions? This is a complex issue, where the medial prefrontal cortex (mPFC) plays a crucial role. The mPFC is essential for cognitive flexibility and decision making. These functions are related to reward- and aversionbased learning, which ultimately drive behavior. Though, cortical projections and modulatory systems that may regulate those processes in the mPFC are less understood. How does the mPFC regulate approach-avoidance behavior in the case of conflicting aversive and appetitive stimuli? This is likely dependent on the bottomup neuromodulation of the mPFC projection neurons. In this review, we integrate behavioral-, pharmacological-, and viral-based circuit manipulation data showing the involvement of mPFC dopaminergic, noradrenergic, cholinergic, and serotoninergic inputs in reward and aversion processing. Given that an incorrect balance of reward and aversion value could be a key problem in mental diseases such as substance use disorders, we discuss outstanding questions for future research on the role of mPFC modulation in reward and aversion." info:eu-repo/date/embargoEnd/2022-04-30 2021-04-19T16:09:15Z 2021-04-19T16:09:15Z 2021-03-04 Artículos de Publicaciones Periódicas info:eu-repo/semantics/publishedVersion 1460-9568 http://ri.itba.edu.ar/handle/123456789/3450 en información: eu-repo/grantAgreement/FONCyT/ PICT/2016-0034/AR. Ciudad Autónoma de Buenos Aires info:eu-repo/semantics/reference/doi.org/10.1111/ejn.15168 info:eu-repo/semantics/embargoedAccess application/pdf
institution Instituto Tecnológico de Buenos Aires (ITBA)
institution_str I-32
repository_str R-138
collection Repositorio Institucional Instituto Tecnológico de Buenos Aires (ITBA)
language Inglés
topic ENFERMEDADES MENTALES
CONDUCTA
CORTEZA PREFRONTAL
NEURONAS
SEROTONINA
NORADRENALINA
DOPAMINA
ACETILCOLINA
spellingShingle ENFERMEDADES MENTALES
CONDUCTA
CORTEZA PREFRONTAL
NEURONAS
SEROTONINA
NORADRENALINA
DOPAMINA
ACETILCOLINA
Pastor, Verónica
Medina, Jorge Horacio
Medial prefrontal cortical control of reward- and aversion-based behavioral output: bottom-up modulation
topic_facet ENFERMEDADES MENTALES
CONDUCTA
CORTEZA PREFRONTAL
NEURONAS
SEROTONINA
NORADRENALINA
DOPAMINA
ACETILCOLINA
description "How does the brain guide our actions? This is a complex issue, where the medial prefrontal cortex (mPFC) plays a crucial role. The mPFC is essential for cognitive flexibility and decision making. These functions are related to reward- and aversionbased learning, which ultimately drive behavior. Though, cortical projections and modulatory systems that may regulate those processes in the mPFC are less understood. How does the mPFC regulate approach-avoidance behavior in the case of conflicting aversive and appetitive stimuli? This is likely dependent on the bottomup neuromodulation of the mPFC projection neurons. In this review, we integrate behavioral-, pharmacological-, and viral-based circuit manipulation data showing the involvement of mPFC dopaminergic, noradrenergic, cholinergic, and serotoninergic inputs in reward and aversion processing. Given that an incorrect balance of reward and aversion value could be a key problem in mental diseases such as substance use disorders, we discuss outstanding questions for future research on the role of mPFC modulation in reward and aversion."
format Artículos de Publicaciones Periódicas
publishedVersion
author Pastor, Verónica
Medina, Jorge Horacio
author_facet Pastor, Verónica
Medina, Jorge Horacio
author_sort Pastor, Verónica
title Medial prefrontal cortical control of reward- and aversion-based behavioral output: bottom-up modulation
title_short Medial prefrontal cortical control of reward- and aversion-based behavioral output: bottom-up modulation
title_full Medial prefrontal cortical control of reward- and aversion-based behavioral output: bottom-up modulation
title_fullStr Medial prefrontal cortical control of reward- and aversion-based behavioral output: bottom-up modulation
title_full_unstemmed Medial prefrontal cortical control of reward- and aversion-based behavioral output: bottom-up modulation
title_sort medial prefrontal cortical control of reward- and aversion-based behavioral output: bottom-up modulation
publishDate info
url http://ri.itba.edu.ar/handle/123456789/3450
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AT medinajorgehoracio medialprefrontalcorticalcontrolofrewardandaversionbasedbehavioraloutputbottomupmodulation
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