Memory reconsolidation as a tool to endure encoding deficits in elderly

"Normal aging involves changes in the ability to acquire, consolidate and recall new information. It has been recently proposed that the reconsolidation process is also affected in older adults. Reconsolidation is triggered after reminder presentation, allowing memories to be modified: they ca...

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Autores principales: Tassone, Leonela M., Urreta Benítez, Facundo A., Rochon, Delfina, Martínez, Paula B., Bonilla, Matías, León, Candela S., Muchnik, Carolina, Solis, Patricia, Medel, Nancy, Kochen, Silvia, Brusco, Luis Ignacio, Moyano, Malen D., Forcato, Cecilia
Formato: Artículos de Publicaciones Periódicas publishedVersion
Lenguaje:Inglés
Publicado: 2020
Materias:
CONSOLIDACION DE LA MEMORIA
EDAD ADULTA
ANCIANOS
RECUPERACION DE INFORMACION
Acceso en línea:http://ri.itba.edu.ar/handle/123456789/2479
Aporte de:
Repositorio Institucional Instituto Tecnológico de Buenos Aires (ITBA) de Instituto Tecnológico de Buenos Aires (ITBA)
id I32-R138-123456789-2479
record_format dspace
spelling I32-R138-123456789-24792022-12-07T13:06:27Z Memory reconsolidation as a tool to endure encoding deficits in elderly Tassone, Leonela M. Urreta Benítez, Facundo A. Rochon, Delfina Martínez, Paula B. Bonilla, Matías León, Candela S. Muchnik, Carolina Solis, Patricia Medel, Nancy Kochen, Silvia Brusco, Luis Ignacio Moyano, Malen D. Forcato, Cecilia CONSOLIDACION DE LA MEMORIA EDAD ADULTA ANCIANOS RECUPERACION DE INFORMACION "Normal aging involves changes in the ability to acquire, consolidate and recall new information. It has been recently proposed that the reconsolidation process is also affected in older adults. Reconsolidation is triggered after reminder presentation, allowing memories to be modified: they can be impaired, strengthened or changed in their content. In young adults it was previously shown that the presentation of repetitive reminders induces memory strengthening one day after reactivation and the presentation of at least one reminder increases memory persistence several days after reactivation. However, until now this process has remained elusive in older adults. We hypothesize that older adults need a stronger reminder to induce memory strengthening through the reconsolidation process than young adults. To test this, we perform a three-day experiment. On day 1, participants learned 15 sound-word associations, on day 2 they received no reminders (NR group), one reminder (R group) or two rounds of reactivations (Rx2 group). Finally, they were tested on day 7. We found that, contrary to our hypothesis, older adults show a memory improvement triggered by repeated labilization/reconsolidation processes to an equal extent than young adults. These results open new perspectives into the use of reconsolidation to improve daily acquired information and the development of therapeutic home used tools to produce memory enhancement in healthy older adults or those with cognitive decline." 2020-08-12T17:46:16Z 2020-08-12T17:46:16Z 2020-08 Artículos de Publicaciones Periódicas info:eu-repo/semantics/publishedVersion 1932-6203 http://ri.itba.edu.ar/handle/123456789/2479 en info:eu-repo/semantics/reference/doi.org/10.1371/journal.pone.0237361 info:eu-repo/grantAgreement/ANPCyT/PICT/2016-0229/AR. Ciudad Autónoma de Buenos Aires http://creativecommons.org/licenses/by-nc-sa/4.0/ application/pdf
institution Instituto Tecnológico de Buenos Aires (ITBA)
institution_str I-32
repository_str R-138
collection Repositorio Institucional Instituto Tecnológico de Buenos Aires (ITBA)
language Inglés
topic CONSOLIDACION DE LA MEMORIA
EDAD ADULTA
ANCIANOS
RECUPERACION DE INFORMACION
spellingShingle CONSOLIDACION DE LA MEMORIA
EDAD ADULTA
ANCIANOS
RECUPERACION DE INFORMACION
Tassone, Leonela M.
Urreta Benítez, Facundo A.
Rochon, Delfina
Martínez, Paula B.
Bonilla, Matías
León, Candela S.
Muchnik, Carolina
Solis, Patricia
Medel, Nancy
Kochen, Silvia
Brusco, Luis Ignacio
Moyano, Malen D.
Forcato, Cecilia
Memory reconsolidation as a tool to endure encoding deficits in elderly
topic_facet CONSOLIDACION DE LA MEMORIA
EDAD ADULTA
ANCIANOS
RECUPERACION DE INFORMACION
description "Normal aging involves changes in the ability to acquire, consolidate and recall new information. It has been recently proposed that the reconsolidation process is also affected in older adults. Reconsolidation is triggered after reminder presentation, allowing memories to be modified: they can be impaired, strengthened or changed in their content. In young adults it was previously shown that the presentation of repetitive reminders induces memory strengthening one day after reactivation and the presentation of at least one reminder increases memory persistence several days after reactivation. However, until now this process has remained elusive in older adults. We hypothesize that older adults need a stronger reminder to induce memory strengthening through the reconsolidation process than young adults. To test this, we perform a three-day experiment. On day 1, participants learned 15 sound-word associations, on day 2 they received no reminders (NR group), one reminder (R group) or two rounds of reactivations (Rx2 group). Finally, they were tested on day 7. We found that, contrary to our hypothesis, older adults show a memory improvement triggered by repeated labilization/reconsolidation processes to an equal extent than young adults. These results open new perspectives into the use of reconsolidation to improve daily acquired information and the development of therapeutic home used tools to produce memory enhancement in healthy older adults or those with cognitive decline."
format Artículos de Publicaciones Periódicas
publishedVersion
author Tassone, Leonela M.
Urreta Benítez, Facundo A.
Rochon, Delfina
Martínez, Paula B.
Bonilla, Matías
León, Candela S.
Muchnik, Carolina
Solis, Patricia
Medel, Nancy
Kochen, Silvia
Brusco, Luis Ignacio
Moyano, Malen D.
Forcato, Cecilia
author_facet Tassone, Leonela M.
Urreta Benítez, Facundo A.
Rochon, Delfina
Martínez, Paula B.
Bonilla, Matías
León, Candela S.
Muchnik, Carolina
Solis, Patricia
Medel, Nancy
Kochen, Silvia
Brusco, Luis Ignacio
Moyano, Malen D.
Forcato, Cecilia
author_sort Tassone, Leonela M.
title Memory reconsolidation as a tool to endure encoding deficits in elderly
title_short Memory reconsolidation as a tool to endure encoding deficits in elderly
title_full Memory reconsolidation as a tool to endure encoding deficits in elderly
title_fullStr Memory reconsolidation as a tool to endure encoding deficits in elderly
title_full_unstemmed Memory reconsolidation as a tool to endure encoding deficits in elderly
title_sort memory reconsolidation as a tool to endure encoding deficits in elderly
publishDate 2020
url http://ri.itba.edu.ar/handle/123456789/2479
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