Differential neurophysiological correlates of retrieval of consolidated and reconsolidated memories in humans: an ERP and pupillometry study

"Consolidated memories can return to a labile state if they are reactivated by unpredictable reminders. To persist, active memories must be re-stabilized through a process known as reconsolidation. Although there is consistent behavioral evidence about this process in humans, the retrieval proc...

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Autores principales: Campos-Arteaga, G., Forcato, Cecilia, Wainstein, G., Lagos, R., Palacios-García, I., Artigas, C., Morales, R., Pedreira, María Eugenia, Rodríguez, E.
Formato: Artículos de Publicaciones Periódicas
Lenguaje:Inglés
Publicado: 2020
Materias:
ELECTROENCEFALOGRAFIA
CONSOLIDACION DE LA MEMORIA
APRENDIZAJE
RECUPERACION DE INFORMACION
CEREBRO
Acceso en línea:http://ri.itba.edu.ar/handle/123456789/2470
Aporte de:
Repositorio Institucional Instituto Tecnológico de Buenos Aires (ITBA) de Instituto Tecnológico de Buenos Aires (ITBA)
id I32-R138-123456789-2470
record_format dspace
spelling I32-R138-123456789-24702022-12-07T13:05:41Z Differential neurophysiological correlates of retrieval of consolidated and reconsolidated memories in humans: an ERP and pupillometry study Campos-Arteaga, G. Forcato, Cecilia Wainstein, G. Lagos, R. Palacios-García, I. Artigas, C. Morales, R. Pedreira, María Eugenia Rodríguez, E. ELECTROENCEFALOGRAFIA CONSOLIDACION DE LA MEMORIA APRENDIZAJE RECUPERACION DE INFORMACION CEREBRO "Consolidated memories can return to a labile state if they are reactivated by unpredictable reminders. To persist, active memories must be re-stabilized through a process known as reconsolidation. Although there is consistent behavioral evidence about this process in humans, the retrieval process of reconsolidated memories remains poorly understood. In this context, one fundamental question is whether the same or different neurophysiological mechanisms are involved in retrieval of consolidated and reconsolidated memories. Because it has been demonstrated that the exposure to the reconsolidation process may restructure and strengthen memories, we hypothesized distinct neurophysiological patterns during retrieval of reconsolidated memories. In addition, we hypothesized that interfering with the reconsolidation process using a new learning can prevent these neurophysiological changes. To test it, consolidated, reconsolidated and declarative memories whose reconsolidation process was interfered (i.e., picture-word pairs) were evaluated in humans in an old/new associative recall task while the brain activity and the pupillary response were recorded using electroencephalography and eyetracking. Our results showed that retrieval of reconsolidated memories elicits specific patterns of brain activation, characterized by an earlier peak latency and a smaller magnitude of the left parietal ERP old/new effect compared to memories that were only consolidated or whose reconsolidation process was interfered by a new learning. Moreover, our results demonstrated that only retrieval of reconsolidated memories is associated with a late reversed mid-frontal effect in a 600–690 time window. Complementarily, memories that were reactivated showed an earlier peak latency of the pupil old/new effect compared to non-reactivated memories. These findings support the idea that reconsolidation has an important impact in how memories are retrieved in the future, showing that retrieval of reconsolidated memories is partially supported by specific brain mechanisms." 2020-08-10T19:42:38Z 2020-08-10T19:42:38Z 2020-10 Artículos de Publicaciones Periódicas 1074-7427 http://ri.itba.edu.ar/handle/123456789/2470 en info:eu-repo/semantics/altIdentifier/doi/10.1016/j.nlm.2020.107279 info:eu-repo/semantics/dataset/10.1016/j.nlm.2020.107279 info:eu-repo/grantAgreement/MEFT/FIC/IS1 30005/CL. Santiago info:eu-repo/grantAgreement/CONICYT/FONDEQUIP/EQM 120027/CL. Santiago info:eu-repo/grantAgreement/CONICYT/FONDECYT/1170145/CL. Santiago application/pdf
institution Instituto Tecnológico de Buenos Aires (ITBA)
institution_str I-32
repository_str R-138
collection Repositorio Institucional Instituto Tecnológico de Buenos Aires (ITBA)
language Inglés
topic ELECTROENCEFALOGRAFIA
CONSOLIDACION DE LA MEMORIA
APRENDIZAJE
RECUPERACION DE INFORMACION
CEREBRO
spellingShingle ELECTROENCEFALOGRAFIA
CONSOLIDACION DE LA MEMORIA
APRENDIZAJE
RECUPERACION DE INFORMACION
CEREBRO
Campos-Arteaga, G.
Forcato, Cecilia
Wainstein, G.
Lagos, R.
Palacios-García, I.
Artigas, C.
Morales, R.
Pedreira, María Eugenia
Rodríguez, E.
Differential neurophysiological correlates of retrieval of consolidated and reconsolidated memories in humans: an ERP and pupillometry study
topic_facet ELECTROENCEFALOGRAFIA
CONSOLIDACION DE LA MEMORIA
APRENDIZAJE
RECUPERACION DE INFORMACION
CEREBRO
description "Consolidated memories can return to a labile state if they are reactivated by unpredictable reminders. To persist, active memories must be re-stabilized through a process known as reconsolidation. Although there is consistent behavioral evidence about this process in humans, the retrieval process of reconsolidated memories remains poorly understood. In this context, one fundamental question is whether the same or different neurophysiological mechanisms are involved in retrieval of consolidated and reconsolidated memories. Because it has been demonstrated that the exposure to the reconsolidation process may restructure and strengthen memories, we hypothesized distinct neurophysiological patterns during retrieval of reconsolidated memories. In addition, we hypothesized that interfering with the reconsolidation process using a new learning can prevent these neurophysiological changes. To test it, consolidated, reconsolidated and declarative memories whose reconsolidation process was interfered (i.e., picture-word pairs) were evaluated in humans in an old/new associative recall task while the brain activity and the pupillary response were recorded using electroencephalography and eyetracking. Our results showed that retrieval of reconsolidated memories elicits specific patterns of brain activation, characterized by an earlier peak latency and a smaller magnitude of the left parietal ERP old/new effect compared to memories that were only consolidated or whose reconsolidation process was interfered by a new learning. Moreover, our results demonstrated that only retrieval of reconsolidated memories is associated with a late reversed mid-frontal effect in a 600–690 time window. Complementarily, memories that were reactivated showed an earlier peak latency of the pupil old/new effect compared to non-reactivated memories. These findings support the idea that reconsolidation has an important impact in how memories are retrieved in the future, showing that retrieval of reconsolidated memories is partially supported by specific brain mechanisms."
format Artículos de Publicaciones Periódicas
author Campos-Arteaga, G.
Forcato, Cecilia
Wainstein, G.
Lagos, R.
Palacios-García, I.
Artigas, C.
Morales, R.
Pedreira, María Eugenia
Rodríguez, E.
author_facet Campos-Arteaga, G.
Forcato, Cecilia
Wainstein, G.
Lagos, R.
Palacios-García, I.
Artigas, C.
Morales, R.
Pedreira, María Eugenia
Rodríguez, E.
author_sort Campos-Arteaga, G.
title Differential neurophysiological correlates of retrieval of consolidated and reconsolidated memories in humans: an ERP and pupillometry study
title_short Differential neurophysiological correlates of retrieval of consolidated and reconsolidated memories in humans: an ERP and pupillometry study
title_full Differential neurophysiological correlates of retrieval of consolidated and reconsolidated memories in humans: an ERP and pupillometry study
title_fullStr Differential neurophysiological correlates of retrieval of consolidated and reconsolidated memories in humans: an ERP and pupillometry study
title_full_unstemmed Differential neurophysiological correlates of retrieval of consolidated and reconsolidated memories in humans: an ERP and pupillometry study
title_sort differential neurophysiological correlates of retrieval of consolidated and reconsolidated memories in humans: an erp and pupillometry study
publishDate 2020
url http://ri.itba.edu.ar/handle/123456789/2470
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