A combined experimental-computational approach for spatial protection efficacy assessment of controlled release devices against mosquitoes (Anopheles)

"This work describes the use of entomological studies combined with in silico models (computer simulations derived from numerical models) to assess the efficacy of a novel device for controlled release of spatial repellents. Controlled Release Devices (CRDs) were tested with different concen...

Descripción completa

Detalles Bibliográficos
Autores principales: Bernier, Ulrich R., Kline, Daniel L., Abad Vázquez, Agustín, Perry, Melynda, Cohnstaedt, Lee W., Gurman, Pablo, D'hers, Sebastián, Elman, Noel M.
Formato: Artículos de Publicaciones Periódicas publishedVersion
Lenguaje:Inglés
Publicado: 2020
Materias:
MOSQUITOS
MALARIA
LIBERACION CONTROLADA
REPELENTES
DENGUE
DINAMICA DE FLUIDOS
CONTROL DE VECTORES
Acceso en línea:http://ri.itba.edu.ar/handle/123456789/2225
Aporte de:
Repositorio Institucional Instituto Tecnológico de Buenos Aires (ITBA) de Instituto Tecnológico de Buenos Aires (ITBA)
id I32-R138-123456789-2225
record_format dspace
spelling I32-R138-123456789-22252022-12-07T13:05:55Z A combined experimental-computational approach for spatial protection efficacy assessment of controlled release devices against mosquitoes (Anopheles) Bernier, Ulrich R. Kline, Daniel L. Abad Vázquez, Agustín Perry, Melynda Cohnstaedt, Lee W. Gurman, Pablo D'hers, Sebastián Elman, Noel M. MOSQUITOS MALARIA LIBERACION CONTROLADA REPELENTES DENGUE DINAMICA DE FLUIDOS CONTROL DE VECTORES "This work describes the use of entomological studies combined with in silico models (computer simulations derived from numerical models) to assess the efficacy of a novel device for controlled release of spatial repellents. Controlled Release Devices (CRDs) were tested with different concentrations of metofluthrin and tested against An. quadrimaculatus mosquitoes using arm-in cage, semi-field, and outdoor studies. Arm-in-cage trials showed an approximate mean values for mosquito knockdown of 40% and mosquito bite reduction of 80% for the optimal metofluthrin formulation for a 15-minute trial. Semi-field outdoor studies showed a mean mortality of a 50% for 24 hour trial and 75% for a 48 hour trial for optimal concentrations. Outdoors studies showed an approximate mean mortality rate of 50% for a 24 hour trial for optimal concentrations. Numerical simulations based on Computational Fluid Dynamics (CFD) were performed in order to obtain spatial concentration profiles for 24 hour and 48 hour periods. Experimental results were correlated with simulation results in order to obtain a functional model that linked mosquito mortality with the estimated spatial concentration for a given period of time. Such correlation provides a powerful insight in predicting the effectiveness of the CRDs as a vector-control tool. While CRDs represent an alternative to current spatial repellent delivery methods, such as coils, candles, electric repellents, and passive emanators based on impregnated strips, the presented method can be applied to any spatial vector control treatment by correlating entomological endpoints, i.e. mortality, with in-silico simulations to predict overall efficacy. The presented work therefore presents a new methodology for improving design, development and deployment of vector-control tools to reduce transmission of vector-borne diseases, including malaria and dengue." 2020-06-25T12:51:04Z 2020-06-25T12:51:04Z 2018-03 Artículos de Publicaciones Periódicas info:eu-repo/semantics/publishedVersion http://ri.itba.edu.ar/handle/123456789/2225 en info:eu-repo/semantics/reference/doi/10.1371/journal.pntd.0007188 info:eu-repo/grantAgreement/GearJump Technologies/US. info:eu-repo/grantAgreement/USDA/: 59-6036-7-001/US. Washington, DC info:eu-repo/grantAgreement/Bill and Melinda Gates Foundation/OPP/1129046/US. Seattle https://creativecommons.org/publicdomain/zero/1.0/ application/pdf
institution Instituto Tecnológico de Buenos Aires (ITBA)
institution_str I-32
repository_str R-138
collection Repositorio Institucional Instituto Tecnológico de Buenos Aires (ITBA)
language Inglés
topic MOSQUITOS
MALARIA
LIBERACION CONTROLADA
REPELENTES
DENGUE
DINAMICA DE FLUIDOS
CONTROL DE VECTORES
spellingShingle MOSQUITOS
MALARIA
LIBERACION CONTROLADA
REPELENTES
DENGUE
DINAMICA DE FLUIDOS
CONTROL DE VECTORES
Bernier, Ulrich R.
Kline, Daniel L.
Abad Vázquez, Agustín
Perry, Melynda
Cohnstaedt, Lee W.
Gurman, Pablo
D'hers, Sebastián
Elman, Noel M.
A combined experimental-computational approach for spatial protection efficacy assessment of controlled release devices against mosquitoes (Anopheles)
topic_facet MOSQUITOS
MALARIA
LIBERACION CONTROLADA
REPELENTES
DENGUE
DINAMICA DE FLUIDOS
CONTROL DE VECTORES
description "This work describes the use of entomological studies combined with in silico models (computer simulations derived from numerical models) to assess the efficacy of a novel device for controlled release of spatial repellents. Controlled Release Devices (CRDs) were tested with different concentrations of metofluthrin and tested against An. quadrimaculatus mosquitoes using arm-in cage, semi-field, and outdoor studies. Arm-in-cage trials showed an approximate mean values for mosquito knockdown of 40% and mosquito bite reduction of 80% for the optimal metofluthrin formulation for a 15-minute trial. Semi-field outdoor studies showed a mean mortality of a 50% for 24 hour trial and 75% for a 48 hour trial for optimal concentrations. Outdoors studies showed an approximate mean mortality rate of 50% for a 24 hour trial for optimal concentrations. Numerical simulations based on Computational Fluid Dynamics (CFD) were performed in order to obtain spatial concentration profiles for 24 hour and 48 hour periods. Experimental results were correlated with simulation results in order to obtain a functional model that linked mosquito mortality with the estimated spatial concentration for a given period of time. Such correlation provides a powerful insight in predicting the effectiveness of the CRDs as a vector-control tool. While CRDs represent an alternative to current spatial repellent delivery methods, such as coils, candles, electric repellents, and passive emanators based on impregnated strips, the presented method can be applied to any spatial vector control treatment by correlating entomological endpoints, i.e. mortality, with in-silico simulations to predict overall efficacy. The presented work therefore presents a new methodology for improving design, development and deployment of vector-control tools to reduce transmission of vector-borne diseases, including malaria and dengue."
format Artículos de Publicaciones Periódicas
publishedVersion
author Bernier, Ulrich R.
Kline, Daniel L.
Abad Vázquez, Agustín
Perry, Melynda
Cohnstaedt, Lee W.
Gurman, Pablo
D'hers, Sebastián
Elman, Noel M.
author_facet Bernier, Ulrich R.
Kline, Daniel L.
Abad Vázquez, Agustín
Perry, Melynda
Cohnstaedt, Lee W.
Gurman, Pablo
D'hers, Sebastián
Elman, Noel M.
author_sort Bernier, Ulrich R.
title A combined experimental-computational approach for spatial protection efficacy assessment of controlled release devices against mosquitoes (Anopheles)
title_short A combined experimental-computational approach for spatial protection efficacy assessment of controlled release devices against mosquitoes (Anopheles)
title_full A combined experimental-computational approach for spatial protection efficacy assessment of controlled release devices against mosquitoes (Anopheles)
title_fullStr A combined experimental-computational approach for spatial protection efficacy assessment of controlled release devices against mosquitoes (Anopheles)
title_full_unstemmed A combined experimental-computational approach for spatial protection efficacy assessment of controlled release devices against mosquitoes (Anopheles)
title_sort combined experimental-computational approach for spatial protection efficacy assessment of controlled release devices against mosquitoes (anopheles)
publishDate 2020
url http://ri.itba.edu.ar/handle/123456789/2225
work_keys_str_mv AT bernierulrichr acombinedexperimentalcomputationalapproachforspatialprotectionefficacyassessmentofcontrolledreleasedevicesagainstmosquitoesanopheles
AT klinedaniell acombinedexperimentalcomputationalapproachforspatialprotectionefficacyassessmentofcontrolledreleasedevicesagainstmosquitoesanopheles
AT abadvazquezagustin acombinedexperimentalcomputationalapproachforspatialprotectionefficacyassessmentofcontrolledreleasedevicesagainstmosquitoesanopheles
AT perrymelynda acombinedexperimentalcomputationalapproachforspatialprotectionefficacyassessmentofcontrolledreleasedevicesagainstmosquitoesanopheles
AT cohnstaedtleew acombinedexperimentalcomputationalapproachforspatialprotectionefficacyassessmentofcontrolledreleasedevicesagainstmosquitoesanopheles
AT gurmanpablo acombinedexperimentalcomputationalapproachforspatialprotectionefficacyassessmentofcontrolledreleasedevicesagainstmosquitoesanopheles
AT dherssebastian acombinedexperimentalcomputationalapproachforspatialprotectionefficacyassessmentofcontrolledreleasedevicesagainstmosquitoesanopheles
AT elmannoelm acombinedexperimentalcomputationalapproachforspatialprotectionefficacyassessmentofcontrolledreleasedevicesagainstmosquitoesanopheles
AT bernierulrichr combinedexperimentalcomputationalapproachforspatialprotectionefficacyassessmentofcontrolledreleasedevicesagainstmosquitoesanopheles
AT klinedaniell combinedexperimentalcomputationalapproachforspatialprotectionefficacyassessmentofcontrolledreleasedevicesagainstmosquitoesanopheles
AT abadvazquezagustin combinedexperimentalcomputationalapproachforspatialprotectionefficacyassessmentofcontrolledreleasedevicesagainstmosquitoesanopheles
AT perrymelynda combinedexperimentalcomputationalapproachforspatialprotectionefficacyassessmentofcontrolledreleasedevicesagainstmosquitoesanopheles
AT cohnstaedtleew combinedexperimentalcomputationalapproachforspatialprotectionefficacyassessmentofcontrolledreleasedevicesagainstmosquitoesanopheles
AT gurmanpablo combinedexperimentalcomputationalapproachforspatialprotectionefficacyassessmentofcontrolledreleasedevicesagainstmosquitoesanopheles
AT dherssebastian combinedexperimentalcomputationalapproachforspatialprotectionefficacyassessmentofcontrolledreleasedevicesagainstmosquitoesanopheles
AT elmannoelm combinedexperimentalcomputationalapproachforspatialprotectionefficacyassessmentofcontrolledreleasedevicesagainstmosquitoesanopheles
_version_ 1765660918454157312

Ejemplares similares