Volume-conducted origin of the field potential at the lateral habenula

"Field potentials (FPs) are easily reached signals that provide information about the brain’s processing. However, FP should be interpreted cautiously since their biophysical bases are complex. The lateral habenula (LHb) is a brain structure involved in the encoding of aversive motivational val...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Bertone-Cueto, Nicolás I., Makarova, Julia, Mosqueira, Alejo, García Violini, Demián, Sánchez-Peña, Ricardo, Herreras, Oscar, Belluscio, Mariano, Piriz, Joaquín
Formato: Artículos de Publicaciones Periódicas publishedVersion
Lenguaje:Inglés
Publicado: 2020
Materias:
CEREBRO
FISIOLOGIA HUMANA
Acceso en línea:http://ri.itba.edu.ar/handle/123456789/1912
Aporte de:
Repositorio Institucional Instituto Tecnológico de Buenos Aires (ITBA) de Instituto Tecnológico de Buenos Aires (ITBA)
id I32-R138-123456789-1912
record_format dspace
spelling I32-R138-123456789-19122022-12-07T13:06:13Z Volume-conducted origin of the field potential at the lateral habenula Bertone-Cueto, Nicolás I. Makarova, Julia Mosqueira, Alejo García Violini, Demián Sánchez-Peña, Ricardo Herreras, Oscar Belluscio, Mariano Piriz, Joaquín CEREBRO FISIOLOGIA HUMANA "Field potentials (FPs) are easily reached signals that provide information about the brain’s processing. However, FP should be interpreted cautiously since their biophysical bases are complex. The lateral habenula (LHb) is a brain structure involved in the encoding of aversive motivational values. Previous work indicates that the activity of the LHb is relevant for hippocampal-dependent learning. Moreover, it has been proposed that the interaction of the LHb with the hippocampal network is evidenced by the synchronization of LHb and hippocampal FPs during theta rhythm. However, the origin of the habenular FP has not been analyzed. Hence, its validity as a measurement of LHb activity has not been proven. In this work, we used electrophysiological recordings in anesthetized rats and feed-forward modeling to investigate biophysical basis of the FP recorded in the LHb. Our results indicate that the FP in the LHb during theta rhythm is a volume-conducted signal from the hippocampus. This result highlight that FPs must be thoroughly analyzed before its biological interpretation and argues against the use of the habenular FP signal as a readout of the activity of the LHb." 2020-03-23T21:51:16Z 2020-03-23T21:51:16Z 2020-01 Artículos de Publicaciones Periódicas info:eu-repo/semantics/publishedVersion 1662-5137 http://ri.itba.edu.ar/handle/123456789/1912 en info:eu-repo/semantics/reference/doi/10.3389/fnsys.2019.00078 info:eu-repo/grantAgreement/BBRF/YI 2015/#23861/US. Nueva York info:eu-repo/grantAgreement/ANPCyT/PICT/2015-2609/AR. Ciudad Autónoma de Buenos Aires info:eu-repo/grantAgreement/ANPCyT/PICT/2017-4594/AR. Ciudad Autónoma de Buenos Aires info:eu-repo/grantAgreement/ANPCyT/PICT/2016-0396/AR. Ciudad Autónoma de Buenos Aires info:eu-repo/grantAgreement/ UBA/UBACyT/2018/AR. Ciudad Autónoma de Buenos Aires info:eu-repo/grantAgreement/ANPCyT/PICT/2017-2417/AR. Ciudad Autónoma de Buenos Aires info:eu-repo/grantAgreement/MINECO/PEIDIORS/SAF2016-80100-R/SP. Madrid https://creativecommons.org/licenses/by/4.0/ application/pdf
institution Instituto Tecnológico de Buenos Aires (ITBA)
institution_str I-32
repository_str R-138
collection Repositorio Institucional Instituto Tecnológico de Buenos Aires (ITBA)
language Inglés
topic CEREBRO
FISIOLOGIA HUMANA
spellingShingle CEREBRO
FISIOLOGIA HUMANA
Bertone-Cueto, Nicolás I.
Makarova, Julia
Mosqueira, Alejo
García Violini, Demián
Sánchez-Peña, Ricardo
Herreras, Oscar
Belluscio, Mariano
Piriz, Joaquín
Volume-conducted origin of the field potential at the lateral habenula
topic_facet CEREBRO
FISIOLOGIA HUMANA
description "Field potentials (FPs) are easily reached signals that provide information about the brain’s processing. However, FP should be interpreted cautiously since their biophysical bases are complex. The lateral habenula (LHb) is a brain structure involved in the encoding of aversive motivational values. Previous work indicates that the activity of the LHb is relevant for hippocampal-dependent learning. Moreover, it has been proposed that the interaction of the LHb with the hippocampal network is evidenced by the synchronization of LHb and hippocampal FPs during theta rhythm. However, the origin of the habenular FP has not been analyzed. Hence, its validity as a measurement of LHb activity has not been proven. In this work, we used electrophysiological recordings in anesthetized rats and feed-forward modeling to investigate biophysical basis of the FP recorded in the LHb. Our results indicate that the FP in the LHb during theta rhythm is a volume-conducted signal from the hippocampus. This result highlight that FPs must be thoroughly analyzed before its biological interpretation and argues against the use of the habenular FP signal as a readout of the activity of the LHb."
format Artículos de Publicaciones Periódicas
publishedVersion
author Bertone-Cueto, Nicolás I.
Makarova, Julia
Mosqueira, Alejo
García Violini, Demián
Sánchez-Peña, Ricardo
Herreras, Oscar
Belluscio, Mariano
Piriz, Joaquín
author_facet Bertone-Cueto, Nicolás I.
Makarova, Julia
Mosqueira, Alejo
García Violini, Demián
Sánchez-Peña, Ricardo
Herreras, Oscar
Belluscio, Mariano
Piriz, Joaquín
author_sort Bertone-Cueto, Nicolás I.
title Volume-conducted origin of the field potential at the lateral habenula
title_short Volume-conducted origin of the field potential at the lateral habenula
title_full Volume-conducted origin of the field potential at the lateral habenula
title_fullStr Volume-conducted origin of the field potential at the lateral habenula
title_full_unstemmed Volume-conducted origin of the field potential at the lateral habenula
title_sort volume-conducted origin of the field potential at the lateral habenula
publishDate 2020
url http://ri.itba.edu.ar/handle/123456789/1912
work_keys_str_mv AT bertonecuetonicolasi volumeconductedoriginofthefieldpotentialatthelateralhabenula
AT makarovajulia volumeconductedoriginofthefieldpotentialatthelateralhabenula
AT mosqueiraalejo volumeconductedoriginofthefieldpotentialatthelateralhabenula
AT garciaviolinidemian volumeconductedoriginofthefieldpotentialatthelateralhabenula
AT sanchezpenaricardo volumeconductedoriginofthefieldpotentialatthelateralhabenula
AT herrerasoscar volumeconductedoriginofthefieldpotentialatthelateralhabenula
AT bellusciomariano volumeconductedoriginofthefieldpotentialatthelateralhabenula
AT pirizjoaquin volumeconductedoriginofthefieldpotentialatthelateralhabenula
_version_ 1765660764979331072

Ejemplares similares