Rapid reconstitution packages (RRPs) for stable storage and delivery of glucagon

"Current emergency injectors of glucagon require manual reconstitution, which involves several steps that may lead to dosage errors. Rapid reconstitution packages (RRPs) are new devices, designed using computational fluid dynamics (CFD) to optimize fluid mixing, integrating physical propertie...

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Detalles Bibliográficos
Autores principales: D'hers, Sebastián, Abad Vázquez, Agustín, Gurman, Pablo, Elman, Noel M.
Formato: Artículos de Publicaciones Periódicas acceptedVersion
Lenguaje:Inglés
Publicado: 2020
Materias:
LIBERACION CONTROLADA
ACELERADORES MAGNETICOS
GLUCANON
DIABETES
DINAMICA DE FLUIDOS
Acceso en línea:http://ri.itba.edu.ar/handle/123456789/1856
Aporte de:
Repositorio Institucional Instituto Tecnológico de Buenos Aires (ITBA) de Instituto Tecnológico de Buenos Aires (ITBA)
id I32-R138-123456789-1856
record_format dspace
spelling I32-R138-123456789-18562022-12-07T13:06:21Z Rapid reconstitution packages (RRPs) for stable storage and delivery of glucagon D'hers, Sebastián Abad Vázquez, Agustín Gurman, Pablo Elman, Noel M. LIBERACION CONTROLADA ACELERADORES MAGNETICOS GLUCANON DIABETES DINAMICA DE FLUIDOS "Current emergency injectors of glucagon require manual reconstitution, which involves several steps that may lead to dosage errors. Rapid reconstitution packages (RRPs) are new devices, designed using computational fluid dynamics (CFD) to optimize fluid mixing, integrating physical properties of active pharmaceutical ingredients (APIs), excipients and diluents. RRPs improve drug stability for long-term storage and ease of delivery. Device prototypes were manufactured using advanced stereolithography apparatus (SLA) 3D printing technology. Reconstitution of glucagon with RRPs was evaluated by highperformance liquid chromatography (HPLC) and optical spectroscopy methods. Enzyme-linked immunosorbent assays were performed to test in vitro activity. Experimental results showed that RRPs effectively reconstituted glucagon even after exposure to 60 °C for a 24-h period. RRPs exhibited improved performance at maintaining drug stability compared to lyophilized glucagon stored in a standard glass vial under the same temperature conditions. RRPs represent a portable platform for rapid reconstitution of lyophilized drugs, compatible with standard syringes available in any clinical setting. The RRP provides an alternative to manual reconstitution process, especially designed for medical emergencies." 2020-01-06T18:42:03Z 2020-01-06T18:42:03Z 2019-06 Artículos de Publicaciones Periódicas info:eu-repo/semantics/acceptedVersion 2190-393X http://ri.itba.edu.ar/handle/123456789/1856 en info:eu-repo/grantAgreement/GearJump Technologies/US. info:eu-repo/grantAgreement/MIT/W911NF-07-D-0004/US. Massachusetts info:eu-repo/semantics/altIdentifier/doi/10.1007/s13346-019-00615-4 application/pdf application/pdf
institution Instituto Tecnológico de Buenos Aires (ITBA)
institution_str I-32
repository_str R-138
collection Repositorio Institucional Instituto Tecnológico de Buenos Aires (ITBA)
language Inglés
topic LIBERACION CONTROLADA
ACELERADORES MAGNETICOS
GLUCANON
DIABETES
DINAMICA DE FLUIDOS
spellingShingle LIBERACION CONTROLADA
ACELERADORES MAGNETICOS
GLUCANON
DIABETES
DINAMICA DE FLUIDOS
D'hers, Sebastián
Abad Vázquez, Agustín
Gurman, Pablo
Elman, Noel M.
Rapid reconstitution packages (RRPs) for stable storage and delivery of glucagon
topic_facet LIBERACION CONTROLADA
ACELERADORES MAGNETICOS
GLUCANON
DIABETES
DINAMICA DE FLUIDOS
description "Current emergency injectors of glucagon require manual reconstitution, which involves several steps that may lead to dosage errors. Rapid reconstitution packages (RRPs) are new devices, designed using computational fluid dynamics (CFD) to optimize fluid mixing, integrating physical properties of active pharmaceutical ingredients (APIs), excipients and diluents. RRPs improve drug stability for long-term storage and ease of delivery. Device prototypes were manufactured using advanced stereolithography apparatus (SLA) 3D printing technology. Reconstitution of glucagon with RRPs was evaluated by highperformance liquid chromatography (HPLC) and optical spectroscopy methods. Enzyme-linked immunosorbent assays were performed to test in vitro activity. Experimental results showed that RRPs effectively reconstituted glucagon even after exposure to 60 °C for a 24-h period. RRPs exhibited improved performance at maintaining drug stability compared to lyophilized glucagon stored in a standard glass vial under the same temperature conditions. RRPs represent a portable platform for rapid reconstitution of lyophilized drugs, compatible with standard syringes available in any clinical setting. The RRP provides an alternative to manual reconstitution process, especially designed for medical emergencies."
format Artículos de Publicaciones Periódicas
acceptedVersion
author D'hers, Sebastián
Abad Vázquez, Agustín
Gurman, Pablo
Elman, Noel M.
author_facet D'hers, Sebastián
Abad Vázquez, Agustín
Gurman, Pablo
Elman, Noel M.
author_sort D'hers, Sebastián
title Rapid reconstitution packages (RRPs) for stable storage and delivery of glucagon
title_short Rapid reconstitution packages (RRPs) for stable storage and delivery of glucagon
title_full Rapid reconstitution packages (RRPs) for stable storage and delivery of glucagon
title_fullStr Rapid reconstitution packages (RRPs) for stable storage and delivery of glucagon
title_full_unstemmed Rapid reconstitution packages (RRPs) for stable storage and delivery of glucagon
title_sort rapid reconstitution packages (rrps) for stable storage and delivery of glucagon
publishDate 2020
url http://ri.itba.edu.ar/handle/123456789/1856
work_keys_str_mv AT dherssebastian rapidreconstitutionpackagesrrpsforstablestorageanddeliveryofglucagon
AT abadvazquezagustin rapidreconstitutionpackagesrrpsforstablestorageanddeliveryofglucagon
AT gurmanpablo rapidreconstitutionpackagesrrpsforstablestorageanddeliveryofglucagon
AT elmannoelm rapidreconstitutionpackagesrrpsforstablestorageanddeliveryofglucagon
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