Electropore formation in mechanically constrained phospholipid bilayers

"Molecular dynamics simulations of lipid bilayers in aqueous systems reveal how an applied electric field stabilizes the reorganization of the water–membrane interface into water-filled, membrane-spanning, conductive pores with a symmetric, toroidal geometry. The pore formation process and the...

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Detalles Bibliográficos
Autores principales: Fernández, María Laura, Risk, Marcelo, Vernier, P. Thomas
Formato: Artículos de Publicaciones Periódicas acceptedVersion
Lenguaje:Inglés
Publicado: 2019
Materias:
DINAMICA MOLECULAR
Acceso en línea:http://ri.itba.edu.ar/handle/123456789/1552
Aporte de:
Repositorio Institucional Instituto Tecnológico de Buenos Aires (ITBA) de Instituto Tecnológico de Buenos Aires (ITBA)
id I32-R138-123456789-1552
record_format dspace
spelling I32-R138-123456789-15522022-12-07T13:06:20Z Electropore formation in mechanically constrained phospholipid bilayers Fernández, María Laura Risk, Marcelo Vernier, P. Thomas DINAMICA MOLECULAR "Molecular dynamics simulations of lipid bilayers in aqueous systems reveal how an applied electric field stabilizes the reorganization of the water–membrane interface into water-filled, membrane-spanning, conductive pores with a symmetric, toroidal geometry. The pore formation process and the resulting symmetric structures are consistent with other mathematical approaches such as continuum models formulated to describe the electroporation process. Some experimental data suggest, however, that the shape of lipid electropores in living cell membranes may be asymmetric. We describe here the axially asym-metric pores that form when mechanical constraints are applied to selected phospholipid atoms. Electropore formation pro-ceeds even with severe constraints in place, but pore shape and pore formation time are affected. Since lateral and transverse movement of phospholipids may be restricted in cell membranes by covalent attachments to or non-covalent associations with other components of the membrane or to membrane-proximate intracellular or extracellular biomolecular assemblies, these lipid-constrained molecular models point the way to more realistic representations of cell membranes in electric fields." 2019-04-22T20:26:25Z 2019-04-22T20:26:25Z 2018-04 Artículos de Publicaciones Periódicas info:eu-repo/semantics/acceptedVersion 0022-2631 http://ri.itba.edu.ar/handle/123456789/1552 en info:eu-repo/grantAgreement/AFOSR/MURI/FA9550-15-1-0517/US. Arlington, VA. info:eu-repo/grantAgreement/AFOSR/FA9550-14-1-0123/US. Arlington, VA. info:eu-repo/grantAgreement/UBA/UBACyT GC/20620130100027BA/AR. Ciudad Autónoma de Buenos Aires info:eu-repo/grantAgreement/CONICET/PIP GI/11220110100379/AR. Ciudad Autónoma de Buenos Aires info:eu-repo/grantAgreement/ITBA/ITBACyT/2015/AR. Ciudad Autónoma de Buenos Aires info:eu-repo/semantics/altIdentifier/doi/10.1007/s00232-017-0002-y application/pdf
institution Instituto Tecnológico de Buenos Aires (ITBA)
institution_str I-32
repository_str R-138
collection Repositorio Institucional Instituto Tecnológico de Buenos Aires (ITBA)
language Inglés
topic DINAMICA MOLECULAR
spellingShingle DINAMICA MOLECULAR
Fernández, María Laura
Risk, Marcelo
Vernier, P. Thomas
Electropore formation in mechanically constrained phospholipid bilayers
topic_facet DINAMICA MOLECULAR
description "Molecular dynamics simulations of lipid bilayers in aqueous systems reveal how an applied electric field stabilizes the reorganization of the water–membrane interface into water-filled, membrane-spanning, conductive pores with a symmetric, toroidal geometry. The pore formation process and the resulting symmetric structures are consistent with other mathematical approaches such as continuum models formulated to describe the electroporation process. Some experimental data suggest, however, that the shape of lipid electropores in living cell membranes may be asymmetric. We describe here the axially asym-metric pores that form when mechanical constraints are applied to selected phospholipid atoms. Electropore formation pro-ceeds even with severe constraints in place, but pore shape and pore formation time are affected. Since lateral and transverse movement of phospholipids may be restricted in cell membranes by covalent attachments to or non-covalent associations with other components of the membrane or to membrane-proximate intracellular or extracellular biomolecular assemblies, these lipid-constrained molecular models point the way to more realistic representations of cell membranes in electric fields."
format Artículos de Publicaciones Periódicas
acceptedVersion
author Fernández, María Laura
Risk, Marcelo
Vernier, P. Thomas
author_facet Fernández, María Laura
Risk, Marcelo
Vernier, P. Thomas
author_sort Fernández, María Laura
title Electropore formation in mechanically constrained phospholipid bilayers
title_short Electropore formation in mechanically constrained phospholipid bilayers
title_full Electropore formation in mechanically constrained phospholipid bilayers
title_fullStr Electropore formation in mechanically constrained phospholipid bilayers
title_full_unstemmed Electropore formation in mechanically constrained phospholipid bilayers
title_sort electropore formation in mechanically constrained phospholipid bilayers
publishDate 2019
url http://ri.itba.edu.ar/handle/123456789/1552
work_keys_str_mv AT fernandezmarialaura electroporeformationinmechanicallyconstrainedphospholipidbilayers
AT riskmarcelo electroporeformationinmechanicallyconstrainedphospholipidbilayers
AT vernierpthomas electroporeformationinmechanicallyconstrainedphospholipidbilayers
_version_ 1765661031489601536

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