Memory extinction entails the inhibition of the transcription factor NF-κB
In contextual memories, an association between a positive or negative reinforcement and the contextual cues where the reinforcement occurs is formed. The re-exposure to the context without reinforcement can lead to memory extinction or reconsolidation, depending on the number of events or duration o...
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| Acceso en línea: | http://hdl.handle.net/20.500.12110/paper_19326203_v3_n11_p_Merlo https://repositoriouba.sisbi.uba.ar/gsdl/cgi-bin/library.cgi?a=d&c=artiaex&d=paper_19326203_v3_n11_p_Merlo_oai |
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I28-R145-paper_19326203_v3_n11_p_Merlo_oai2024-08-16 Merlo, E. Romano, A. 2008 In contextual memories, an association between a positive or negative reinforcement and the contextual cues where the reinforcement occurs is formed. The re-exposure to the context without reinforcement can lead to memory extinction or reconsolidation, depending on the number of events or duration of a single event of context re-exposure. Extinction involves the temporary waning of the previously acquired conditioned response. The molecular processes underlying extinction and the mechanisms which determine if memory will reconsolidate or extinguish after retrieval are not well characterized, particularly the role of transcription factors and gene expression. Here we studied the participation of a transcription factor, NF-κB, in memory extinction. In the crab context-signal memory, the activation of NF-κB plays a critical role in consolidation and reconsolidation, memory processes that are well characterized in this model. The administration of a NF-κB inhibitor, sulfasalazine prior to extinction session impeded spontaneous recovery. Moreover, reinstatement experiments showed that the original memory was not affected and that NF-κB inhibition by sulfasalazine impaired spontaneous recovery strengthening the ongoing memory extinction process. Interestingly, in animals with fully consolidated memory, a brief re-exposure to the training context induced neuronal NF-κB activation and reconsolidation, while prolonged re-exposure induced NF-κB inhibition and memory extinction. These data constitutes a novel insight into the molecular mechanisms involved in the switch between memory reconsolidation and extinction. Moreover, we propose the inhibition of NF-κB as the engaged mechanism underlying extinction, supporting a novel approach for the pharmacological enhancement of this memory process. The accurate description of the molecular mechanisms that support memory extinction is potentially useful for developing new strategies and drug candidates for therapeutic treatments of the maladaptive memory disorders such as post-traumatic stress, phobias, and drug addiction. © 2008 Merlo, Romano. Fil:Merlo, E. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Romano, A. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. application/pdf http://hdl.handle.net/20.500.12110/paper_19326203_v3_n11_p_Merlo info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar PLoS ONE 2008;3(11) immunoglobulin enhancer binding protein salazosulfapyridine immunoglobulin enhancer binding protein article brain function controlled study gene expression memory consolidation memory disorder molecular mechanics nonhuman pharmacological blocking transcription initiation working memory animal Brachyura drug antagonism long term memory male memory metabolism physiology reinforcement Animalia Decapoda (Crustacea) Animals Brachyura Extinction, Psychological Male Memory NF-kappa B Retention (Psychology) Memory extinction entails the inhibition of the transcription factor NF-κB info:eu-repo/semantics/article info:ar-repo/semantics/artículo info:eu-repo/semantics/publishedVersion https://repositoriouba.sisbi.uba.ar/gsdl/cgi-bin/library.cgi?a=d&c=artiaex&d=paper_19326203_v3_n11_p_Merlo_oai |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-145 |
| collection |
Repositorio Digital de la Universidad de Buenos Aires (UBA) |
| topic |
immunoglobulin enhancer binding protein salazosulfapyridine immunoglobulin enhancer binding protein article brain function controlled study gene expression memory consolidation memory disorder molecular mechanics nonhuman pharmacological blocking transcription initiation working memory animal Brachyura drug antagonism long term memory male memory metabolism physiology reinforcement Animalia Decapoda (Crustacea) Animals Brachyura Extinction, Psychological Male Memory NF-kappa B Retention (Psychology) |
| spellingShingle |
immunoglobulin enhancer binding protein salazosulfapyridine immunoglobulin enhancer binding protein article brain function controlled study gene expression memory consolidation memory disorder molecular mechanics nonhuman pharmacological blocking transcription initiation working memory animal Brachyura drug antagonism long term memory male memory metabolism physiology reinforcement Animalia Decapoda (Crustacea) Animals Brachyura Extinction, Psychological Male Memory NF-kappa B Retention (Psychology) Merlo, E. Romano, A. Memory extinction entails the inhibition of the transcription factor NF-κB |
| topic_facet |
immunoglobulin enhancer binding protein salazosulfapyridine immunoglobulin enhancer binding protein article brain function controlled study gene expression memory consolidation memory disorder molecular mechanics nonhuman pharmacological blocking transcription initiation working memory animal Brachyura drug antagonism long term memory male memory metabolism physiology reinforcement Animalia Decapoda (Crustacea) Animals Brachyura Extinction, Psychological Male Memory NF-kappa B Retention (Psychology) |
| description |
In contextual memories, an association between a positive or negative reinforcement and the contextual cues where the reinforcement occurs is formed. The re-exposure to the context without reinforcement can lead to memory extinction or reconsolidation, depending on the number of events or duration of a single event of context re-exposure. Extinction involves the temporary waning of the previously acquired conditioned response. The molecular processes underlying extinction and the mechanisms which determine if memory will reconsolidate or extinguish after retrieval are not well characterized, particularly the role of transcription factors and gene expression. Here we studied the participation of a transcription factor, NF-κB, in memory extinction. In the crab context-signal memory, the activation of NF-κB plays a critical role in consolidation and reconsolidation, memory processes that are well characterized in this model. The administration of a NF-κB inhibitor, sulfasalazine prior to extinction session impeded spontaneous recovery. Moreover, reinstatement experiments showed that the original memory was not affected and that NF-κB inhibition by sulfasalazine impaired spontaneous recovery strengthening the ongoing memory extinction process. Interestingly, in animals with fully consolidated memory, a brief re-exposure to the training context induced neuronal NF-κB activation and reconsolidation, while prolonged re-exposure induced NF-κB inhibition and memory extinction. These data constitutes a novel insight into the molecular mechanisms involved in the switch between memory reconsolidation and extinction. Moreover, we propose the inhibition of NF-κB as the engaged mechanism underlying extinction, supporting a novel approach for the pharmacological enhancement of this memory process. The accurate description of the molecular mechanisms that support memory extinction is potentially useful for developing new strategies and drug candidates for therapeutic treatments of the maladaptive memory disorders such as post-traumatic stress, phobias, and drug addiction. © 2008 Merlo, Romano. |
| format |
Artículo Artículo publishedVersion |
| author |
Merlo, E. Romano, A. |
| author_facet |
Merlo, E. Romano, A. |
| author_sort |
Merlo, E. |
| title |
Memory extinction entails the inhibition of the transcription factor NF-κB |
| title_short |
Memory extinction entails the inhibition of the transcription factor NF-κB |
| title_full |
Memory extinction entails the inhibition of the transcription factor NF-κB |
| title_fullStr |
Memory extinction entails the inhibition of the transcription factor NF-κB |
| title_full_unstemmed |
Memory extinction entails the inhibition of the transcription factor NF-κB |
| title_sort |
memory extinction entails the inhibition of the transcription factor nf-κb |
| publishDate |
2008 |
| url |
http://hdl.handle.net/20.500.12110/paper_19326203_v3_n11_p_Merlo https://repositoriouba.sisbi.uba.ar/gsdl/cgi-bin/library.cgi?a=d&c=artiaex&d=paper_19326203_v3_n11_p_Merlo_oai |
| work_keys_str_mv |
AT merloe memoryextinctionentailstheinhibitionofthetranscriptionfactornfkb AT romanoa memoryextinctionentailstheinhibitionofthetranscriptionfactornfkb |
| _version_ |
1809357032211349504 |