Turing patterns inside cells

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Concentration gradients inside cells are involved in key processes such as cell division and morphogenesis. Here we show that a model of the enzymatic step catalized by phosphofructokinase (PFK), a step which is responsible for the appearance of homogeneous oscillations in the glycolytic pathway, di...

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Autores principales:	Strier, D.E., Dawson, S.P.
Formato:	Artículo publishedVersion
Publicado:	2007
Materias:	6 phosphofructokinase adenosine diphosphate adenosine triphosphate animal cell article catalysis cell division cell metabolism cell size concentration response diffusion coefficient enzyme kinetics enzyme mechanism glycolysis mathematical computing molecular mechanics nonhuman oscillation protein protein interaction regulatory mechanism steady state yeast biological model biophysics chemical model chemistry diffusion metabolism methodology morphogenesis oscillometry theoretical model Adenosine Diphosphate Adenosine Triphosphate Biophysics Catalysis Cell Division Diffusion Glycolysis Models, Biological Models, Chemical Models, Theoretical Morphogenesis Oscillometry Phosphofructokinases
Acceso en línea:	http://hdl.handle.net/20.500.12110/paper_19326203_v2_n10_p_Strier https://repositoriouba.sisbi.uba.ar/gsdl/cgi-bin/library.cgi?a=d&c=artiaex&d=paper_19326203_v2_n10_p_Strier_oai
Aporte de:	Repositorio Digital de la Universidad de Buenos Aires (UBA) de Universidad de Buenos Aires

id	I28-R145-paper_19326203_v2_n10_p_Strier_oai
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spelling	I28-R145-paper_19326203_v2_n10_p_Strier_oai2024-08-16 Strier, D.E. Dawson, S.P. 2007 Concentration gradients inside cells are involved in key processes such as cell division and morphogenesis. Here we show that a model of the enzymatic step catalized by phosphofructokinase (PFK), a step which is responsible for the appearance of homogeneous oscillations in the glycolytic pathway, displays Turing patterns with an intrinsic length-scale that is smaller than a typical cell size. All the parameter values are fully consistent with classic experiments on glycolytic oscillations and equal diffusion coefficients are assumed for ATP and ADP. We identify the enzyme concentration and the glycolytic flux as the possible regulators of the pattern. To the best of our knowledge, this is the first closed example of Turing pattern formation in a model of a vital step of the cell metabolism, with a built-in mechanism for changing the diffusion length of the reactants, and with parameter values that are compatible with experiments. Turing patterns inside cells could provide a check-point that combines mechanical and biochemical information to trigger events during the cell division process. © 2007 Strier, Ponce Dawson. Fil:Strier, D.E. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Dawson, S.P. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. application/pdf http://hdl.handle.net/20.500.12110/paper_19326203_v2_n10_p_Strier info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar PLoS ONE 2007;2(10) 6 phosphofructokinase adenosine diphosphate adenosine triphosphate 6 phosphofructokinase adenosine diphosphate adenosine triphosphate animal cell article catalysis cell division cell metabolism cell size concentration response diffusion coefficient enzyme kinetics enzyme mechanism glycolysis mathematical computing molecular mechanics nonhuman oscillation protein protein interaction regulatory mechanism steady state yeast biological model biophysics chemical model chemistry diffusion glycolysis metabolism methodology morphogenesis oscillometry theoretical model Adenosine Diphosphate Adenosine Triphosphate Biophysics Catalysis Cell Division Diffusion Glycolysis Models, Biological Models, Chemical Models, Theoretical Morphogenesis Oscillometry Phosphofructokinases Turing patterns inside cells info:eu-repo/semantics/article info:ar-repo/semantics/artículo info:eu-repo/semantics/publishedVersion https://repositoriouba.sisbi.uba.ar/gsdl/cgi-bin/library.cgi?a=d&c=artiaex&d=paper_19326203_v2_n10_p_Strier_oai
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-145
collection	Repositorio Digital de la Universidad de Buenos Aires (UBA)
topic	6 phosphofructokinase adenosine diphosphate adenosine triphosphate 6 phosphofructokinase adenosine diphosphate adenosine triphosphate animal cell article catalysis cell division cell metabolism cell size concentration response diffusion coefficient enzyme kinetics enzyme mechanism glycolysis mathematical computing molecular mechanics nonhuman oscillation protein protein interaction regulatory mechanism steady state yeast biological model biophysics chemical model chemistry diffusion glycolysis metabolism methodology morphogenesis oscillometry theoretical model Adenosine Diphosphate Adenosine Triphosphate Biophysics Catalysis Cell Division Diffusion Glycolysis Models, Biological Models, Chemical Models, Theoretical Morphogenesis Oscillometry Phosphofructokinases
spellingShingle	6 phosphofructokinase adenosine diphosphate adenosine triphosphate 6 phosphofructokinase adenosine diphosphate adenosine triphosphate animal cell article catalysis cell division cell metabolism cell size concentration response diffusion coefficient enzyme kinetics enzyme mechanism glycolysis mathematical computing molecular mechanics nonhuman oscillation protein protein interaction regulatory mechanism steady state yeast biological model biophysics chemical model chemistry diffusion glycolysis metabolism methodology morphogenesis oscillometry theoretical model Adenosine Diphosphate Adenosine Triphosphate Biophysics Catalysis Cell Division Diffusion Glycolysis Models, Biological Models, Chemical Models, Theoretical Morphogenesis Oscillometry Phosphofructokinases Strier, D.E. Dawson, S.P. Turing patterns inside cells
topic_facet	6 phosphofructokinase adenosine diphosphate adenosine triphosphate 6 phosphofructokinase adenosine diphosphate adenosine triphosphate animal cell article catalysis cell division cell metabolism cell size concentration response diffusion coefficient enzyme kinetics enzyme mechanism glycolysis mathematical computing molecular mechanics nonhuman oscillation protein protein interaction regulatory mechanism steady state yeast biological model biophysics chemical model chemistry diffusion glycolysis metabolism methodology morphogenesis oscillometry theoretical model Adenosine Diphosphate Adenosine Triphosphate Biophysics Catalysis Cell Division Diffusion Glycolysis Models, Biological Models, Chemical Models, Theoretical Morphogenesis Oscillometry Phosphofructokinases
description	Concentration gradients inside cells are involved in key processes such as cell division and morphogenesis. Here we show that a model of the enzymatic step catalized by phosphofructokinase (PFK), a step which is responsible for the appearance of homogeneous oscillations in the glycolytic pathway, displays Turing patterns with an intrinsic length-scale that is smaller than a typical cell size. All the parameter values are fully consistent with classic experiments on glycolytic oscillations and equal diffusion coefficients are assumed for ATP and ADP. We identify the enzyme concentration and the glycolytic flux as the possible regulators of the pattern. To the best of our knowledge, this is the first closed example of Turing pattern formation in a model of a vital step of the cell metabolism, with a built-in mechanism for changing the diffusion length of the reactants, and with parameter values that are compatible with experiments. Turing patterns inside cells could provide a check-point that combines mechanical and biochemical information to trigger events during the cell division process. © 2007 Strier, Ponce Dawson.
format	Artículo Artículo publishedVersion
author	Strier, D.E. Dawson, S.P.
author_facet	Strier, D.E. Dawson, S.P.
author_sort	Strier, D.E.
title	Turing patterns inside cells
title_short	Turing patterns inside cells
title_full	Turing patterns inside cells
title_fullStr	Turing patterns inside cells
title_full_unstemmed	Turing patterns inside cells
title_sort	turing patterns inside cells
publishDate	2007
url	http://hdl.handle.net/20.500.12110/paper_19326203_v2_n10_p_Strier https://repositoriouba.sisbi.uba.ar/gsdl/cgi-bin/library.cgi?a=d&c=artiaex&d=paper_19326203_v2_n10_p_Strier_oai
work_keys_str_mv	AT strierde turingpatternsinsidecells AT dawsonsp turingpatternsinsidecells
_version_	1809357126327336960

Turing patterns inside cells

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