Mean field strategies induce unrealistic non-linearities in calcium puffs
Mean field models are often useful approximations to biological systems, but sometimes, they can yield misleading results. In this work, we compare mean field approaches with stochastic models of intracellular calcium release. In particular, we concentrate on calcium signals generated by the concert...
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I28-R145-paper_1664042X_v2AUG_n_p_Solovey_oai2020-10-19 Solovey, G. Fraiman, D. Dawson, S.P. 2011 Mean field models are often useful approximations to biological systems, but sometimes, they can yield misleading results. In this work, we compare mean field approaches with stochastic models of intracellular calcium release. In particular, we concentrate on calcium signals generated by the concerted opening of several clustered channels (calcium puffs). To this end we simulate calcium puffs numerically and then try to reproduce features of the resulting calcium distribution using mean field models were all the channels open and close simultaneously. We show that an unrealistic non-linear relationship between the current and the number of open channels is needed to reproduce the simulated puffs. Furthermore, a single channel current which is five times smaller than the one of the stochastic simulations is also needed. Our study sheds light on the importance of the stochastic kinetics of the calcium release channel activity to estimate the release fluxes. © 2011 Solovey, Fraiman and Dawson. Fil:Solovey, G. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Dawson, S.P. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. application/pdf http://hdl.handle.net/20.500.12110/paper_1664042X_v2AUG_n_p_Solovey info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar Front. Physiol. 2011;2 AUG Calcium signals Mean field model Puffs Stochastic model Mean field strategies induce unrealistic non-linearities in calcium puffs info:eu-repo/semantics/article info:ar-repo/semantics/artículo info:eu-repo/semantics/publishedVersion http://repositoriouba.sisbi.uba.ar/gsdl/cgi-bin/library.cgi?a=d&c=artiaex&d=paper_1664042X_v2AUG_n_p_Solovey_oai |
institution |
Universidad de Buenos Aires |
institution_str |
I-28 |
repository_str |
R-145 |
collection |
Repositorio Digital de la Universidad de Buenos Aires (UBA) |
topic |
Calcium signals Mean field model Puffs Stochastic model |
spellingShingle |
Calcium signals Mean field model Puffs Stochastic model Solovey, G. Fraiman, D. Dawson, S.P. Mean field strategies induce unrealistic non-linearities in calcium puffs |
topic_facet |
Calcium signals Mean field model Puffs Stochastic model |
description |
Mean field models are often useful approximations to biological systems, but sometimes, they can yield misleading results. In this work, we compare mean field approaches with stochastic models of intracellular calcium release. In particular, we concentrate on calcium signals generated by the concerted opening of several clustered channels (calcium puffs). To this end we simulate calcium puffs numerically and then try to reproduce features of the resulting calcium distribution using mean field models were all the channels open and close simultaneously. We show that an unrealistic non-linear relationship between the current and the number of open channels is needed to reproduce the simulated puffs. Furthermore, a single channel current which is five times smaller than the one of the stochastic simulations is also needed. Our study sheds light on the importance of the stochastic kinetics of the calcium release channel activity to estimate the release fluxes. © 2011 Solovey, Fraiman and Dawson. |
format |
Artículo Artículo publishedVersion |
author |
Solovey, G. Fraiman, D. Dawson, S.P. |
author_facet |
Solovey, G. Fraiman, D. Dawson, S.P. |
author_sort |
Solovey, G. |
title |
Mean field strategies induce unrealistic non-linearities in calcium puffs |
title_short |
Mean field strategies induce unrealistic non-linearities in calcium puffs |
title_full |
Mean field strategies induce unrealistic non-linearities in calcium puffs |
title_fullStr |
Mean field strategies induce unrealistic non-linearities in calcium puffs |
title_full_unstemmed |
Mean field strategies induce unrealistic non-linearities in calcium puffs |
title_sort |
mean field strategies induce unrealistic non-linearities in calcium puffs |
publishDate |
2011 |
url |
http://hdl.handle.net/20.500.12110/paper_1664042X_v2AUG_n_p_Solovey http://repositoriouba.sisbi.uba.ar/gsdl/cgi-bin/library.cgi?a=d&c=artiaex&d=paper_1664042X_v2AUG_n_p_Solovey_oai |
work_keys_str_mv |
AT soloveyg meanfieldstrategiesinduceunrealisticnonlinearitiesincalciumpuffs AT fraimand meanfieldstrategiesinduceunrealisticnonlinearitiesincalciumpuffs AT dawsonsp meanfieldstrategiesinduceunrealisticnonlinearitiesincalciumpuffs |
_version_ |
1766026788758093824 |