Cytotoxic tirucallane triterpenoids from Melia azedarach fruits

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The phytochemical investigation of the dichloromethane-soluble part of the methanol extract obtained from the fruits of Melia azedarach afforded one new tirucallanetype triterpene, 3-α-tigloylmelianol (1) and three known tirucallanes, melianone (2), 21-β-acetoxy-melianone (3), and methyl kulonate (4...

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Autores principales:	Ntalli, N.G., Cottiglia, F., Bueno, C.A., Alché, L.E., Leonti, M., Vargiu, S., Bifulco, E., Menkissoglu-Spiroudi, U., Caboni, P.
Formato:	Artículo publishedVersion
Publicado:	2010
Materias:	21-β-Acetoxy- melianone 3-α-Tigloylmelianol Cytotoxicity Melianone Methyl kulonate cytotoxin plant extract tirucallane triterpene adenocarcinoma animal article chemical structure chemistry drug effect epithelium cell fruit human isolation and purification lung tumor Melia azedarach nematode pathology tumor cell line Adenocarcinoma Animals Cell Line, Tumor Cytotoxins Epithelial Cells Fruit Humans Lung Neoplasms Molecular Structure Plant Extracts Triterpenes Tylenchoidea
Acceso en línea:	http://hdl.handle.net/20.500.12110/paper_14203049_v15_n9_p5866_Ntalli http://repositoriouba.sisbi.uba.ar/gsdl/cgi-bin/library.cgi?a=d&c=artiaex&d=paper_14203049_v15_n9_p5866_Ntalli_oai
Aporte de:	Repositorio Digital de la Universidad de Buenos Aires (UBA) de Universidad de Buenos Aires

id	I28-R145-paper_14203049_v15_n9_p5866_Ntalli_oai
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spelling	I28-R145-paper_14203049_v15_n9_p5866_Ntalli_oai2020-10-19 Ntalli, N.G. Cottiglia, F. Bueno, C.A. Alché, L.E. Leonti, M. Vargiu, S. Bifulco, E. Menkissoglu-Spiroudi, U. Caboni, P. 2010 The phytochemical investigation of the dichloromethane-soluble part of the methanol extract obtained from the fruits of Melia azedarach afforded one new tirucallanetype triterpene, 3-α-tigloylmelianol (1) and three known tirucallanes, melianone (2), 21-β-acetoxy-melianone (3), and methyl kulonate (4). The structure of the isolated compounds was mainly determined by 1D and 2D NMR experiments as well as HPLC-Q-TOF mass spectrometry. The cytotoxicity of the isolated compounds toward the human lung adenocarcinoma epithelial cell line A549 was determined, while no activity was observed against the phytonematode Meloidogyne incognita. © 2010 by the authors. Fil:Bueno, C.A. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Alché, L.E. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. application/pdf http://hdl.handle.net/20.500.12110/paper_14203049_v15_n9_p5866_Ntalli info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar Molecules 2010;15(9):5866-5877 21-β-Acetoxy- melianone 3-α-Tigloylmelianol Cytotoxicity Melianone Methyl kulonate cytotoxin plant extract tirucallane triterpene adenocarcinoma animal article chemical structure chemistry drug effect epithelium cell fruit human isolation and purification lung tumor Melia azedarach nematode pathology tumor cell line Adenocarcinoma Animals Cell Line, Tumor Cytotoxins Epithelial Cells Fruit Humans Lung Neoplasms Melia azedarach Molecular Structure Plant Extracts Triterpenes Tylenchoidea Cytotoxic tirucallane triterpenoids from Melia azedarach fruits info:eu-repo/semantics/article info:ar-repo/semantics/artículo info:eu-repo/semantics/publishedVersion http://repositoriouba.sisbi.uba.ar/gsdl/cgi-bin/library.cgi?a=d&c=artiaex&d=paper_14203049_v15_n9_p5866_Ntalli_oai
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-145
collection	Repositorio Digital de la Universidad de Buenos Aires (UBA)
topic	21-β-Acetoxy- melianone 3-α-Tigloylmelianol Cytotoxicity Melianone Methyl kulonate cytotoxin plant extract tirucallane triterpene adenocarcinoma animal article chemical structure chemistry drug effect epithelium cell fruit human isolation and purification lung tumor Melia azedarach nematode pathology tumor cell line Adenocarcinoma Animals Cell Line, Tumor Cytotoxins Epithelial Cells Fruit Humans Lung Neoplasms Melia azedarach Molecular Structure Plant Extracts Triterpenes Tylenchoidea
spellingShingle	21-β-Acetoxy- melianone 3-α-Tigloylmelianol Cytotoxicity Melianone Methyl kulonate cytotoxin plant extract tirucallane triterpene adenocarcinoma animal article chemical structure chemistry drug effect epithelium cell fruit human isolation and purification lung tumor Melia azedarach nematode pathology tumor cell line Adenocarcinoma Animals Cell Line, Tumor Cytotoxins Epithelial Cells Fruit Humans Lung Neoplasms Melia azedarach Molecular Structure Plant Extracts Triterpenes Tylenchoidea Ntalli, N.G. Cottiglia, F. Bueno, C.A. Alché, L.E. Leonti, M. Vargiu, S. Bifulco, E. Menkissoglu-Spiroudi, U. Caboni, P. Cytotoxic tirucallane triterpenoids from Melia azedarach fruits
topic_facet	21-β-Acetoxy- melianone 3-α-Tigloylmelianol Cytotoxicity Melianone Methyl kulonate cytotoxin plant extract tirucallane triterpene adenocarcinoma animal article chemical structure chemistry drug effect epithelium cell fruit human isolation and purification lung tumor Melia azedarach nematode pathology tumor cell line Adenocarcinoma Animals Cell Line, Tumor Cytotoxins Epithelial Cells Fruit Humans Lung Neoplasms Melia azedarach Molecular Structure Plant Extracts Triterpenes Tylenchoidea
description	The phytochemical investigation of the dichloromethane-soluble part of the methanol extract obtained from the fruits of Melia azedarach afforded one new tirucallanetype triterpene, 3-α-tigloylmelianol (1) and three known tirucallanes, melianone (2), 21-β-acetoxy-melianone (3), and methyl kulonate (4). The structure of the isolated compounds was mainly determined by 1D and 2D NMR experiments as well as HPLC-Q-TOF mass spectrometry. The cytotoxicity of the isolated compounds toward the human lung adenocarcinoma epithelial cell line A549 was determined, while no activity was observed against the phytonematode Meloidogyne incognita. © 2010 by the authors.
format	Artículo Artículo publishedVersion
author	Ntalli, N.G. Cottiglia, F. Bueno, C.A. Alché, L.E. Leonti, M. Vargiu, S. Bifulco, E. Menkissoglu-Spiroudi, U. Caboni, P.
author_facet	Ntalli, N.G. Cottiglia, F. Bueno, C.A. Alché, L.E. Leonti, M. Vargiu, S. Bifulco, E. Menkissoglu-Spiroudi, U. Caboni, P.
author_sort	Ntalli, N.G.
title	Cytotoxic tirucallane triterpenoids from Melia azedarach fruits
title_short	Cytotoxic tirucallane triterpenoids from Melia azedarach fruits
title_full	Cytotoxic tirucallane triterpenoids from Melia azedarach fruits
title_fullStr	Cytotoxic tirucallane triterpenoids from Melia azedarach fruits
title_full_unstemmed	Cytotoxic tirucallane triterpenoids from Melia azedarach fruits
title_sort	cytotoxic tirucallane triterpenoids from melia azedarach fruits
publishDate	2010
url	http://hdl.handle.net/20.500.12110/paper_14203049_v15_n9_p5866_Ntalli http://repositoriouba.sisbi.uba.ar/gsdl/cgi-bin/library.cgi?a=d&c=artiaex&d=paper_14203049_v15_n9_p5866_Ntalli_oai
work_keys_str_mv	AT ntalling cytotoxictirucallanetriterpenoidsfrommeliaazedarachfruits AT cottigliaf cytotoxictirucallanetriterpenoidsfrommeliaazedarachfruits AT buenoca cytotoxictirucallanetriterpenoidsfrommeliaazedarachfruits AT alchele cytotoxictirucallanetriterpenoidsfrommeliaazedarachfruits AT leontim cytotoxictirucallanetriterpenoidsfrommeliaazedarachfruits AT vargius cytotoxictirucallanetriterpenoidsfrommeliaazedarachfruits AT bifulcoe cytotoxictirucallanetriterpenoidsfrommeliaazedarachfruits AT menkissogluspiroudiu cytotoxictirucallanetriterpenoidsfrommeliaazedarachfruits AT cabonip cytotoxictirucallanetriterpenoidsfrommeliaazedarachfruits
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Cytotoxic tirucallane triterpenoids from Melia azedarach fruits

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