Reconsolidation or extinction: Transcription factor switch in the determination of memory course after retrieval

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In fear conditioning, aversive stimuli are readily associated with contextual features. A brief reexposure to the training context causes fear memory reconsolidation, whereas a prolonged re exposure induces memory extinction. The regulation of hippocampal gene expression plays akey role in contextua...

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Autores principales: de la Fuente, V., Freudenthal, R., Romano, A.
Formato: Artículo publishedVersion
Publicado: 2011
Materias:
calcineurin
immunoglobulin enhancer binding protein
transcription factor NFAT
amino acid sequence
animal experiment
animal tissue
article
controlled study
DNA determination
enzyme inhibition
long term memory
male
memory consolidation
molecular dynamics
mouse
nonhuman
priority journal
protein analysis
protein function
reinforcement
transcription initiation
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_02706474_v31_n15_p5562_delaFuente
https://repositoriouba.sisbi.uba.ar/gsdl/cgi-bin/library.cgi?a=d&c=artiaex&d=paper_02706474_v31_n15_p5562_delaFuente_oai
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Repositorio Digital de la Universidad de Buenos Aires (UBA) de Universidad de Buenos Aires
id I28-R145-paper_02706474_v31_n15_p5562_delaFuente_oai
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spelling I28-R145-paper_02706474_v31_n15_p5562_delaFuente_oai2024-08-16 de la Fuente, V. Freudenthal, R. Romano, A. 2011 In fear conditioning, aversive stimuli are readily associated with contextual features. A brief reexposure to the training context causes fear memory reconsolidation, whereas a prolonged re exposure induces memory extinction. The regulation of hippocampal gene expression plays akey role in contextual memory consolidation and reconsolidation. However, the mechanisms that determine whether memory will reconsolidate or extinguish are not known. Here, we demonstrate opposing roles for two evolutionarily related transcription factors in the mouse hippocampus. We found that nuclear factor-KB (NF-kB) is required for fear memory reconsolidation. Conversely, calcineurin phosphatase inhibited NF-kB and induced nuclear factor of activated T-cells (NFAT) nuclear translocation in the transition between reconsolidation and extinction. Accordingly, the hippocampal inhibition of both calcineurin and NFAT independently impaired memory extinction, whereas inhibition of NF-kB enhanced memory extinction. These findings represent the first insight into the molecular mechanisms that determine memory reprocessing after retrieval, supporting a transcriptional switch that directs memory toward reconsolidation or extinction. The precise molecular characterization of postretrieval processes has potential importance to the development of therapeutic strategies for fear memory disorders. © 2011 the authors. Fil:de la Fuente, V. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Freudenthal, R. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Romano, A. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. application/pdf http://hdl.handle.net/20.500.12110/paper_02706474_v31_n15_p5562_delaFuente info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar J. Neurosci. 2011;31(15):5562-5573 calcineurin immunoglobulin enhancer binding protein transcription factor NFAT amino acid sequence animal experiment animal tissue article controlled study DNA determination enzyme inhibition long term memory male memory consolidation molecular dynamics mouse nonhuman priority journal protein analysis protein function reinforcement transcription initiation Reconsolidation or extinction: Transcription factor switch in the determination of memory course after retrieval info:eu-repo/semantics/article info:ar-repo/semantics/artículo info:eu-repo/semantics/publishedVersion https://repositoriouba.sisbi.uba.ar/gsdl/cgi-bin/library.cgi?a=d&c=artiaex&d=paper_02706474_v31_n15_p5562_delaFuente_oai
institution Universidad de Buenos Aires
institution_str I-28
repository_str R-145
collection Repositorio Digital de la Universidad de Buenos Aires (UBA)
topic calcineurin
immunoglobulin enhancer binding protein
transcription factor NFAT
amino acid sequence
animal experiment
animal tissue
article
controlled study
DNA determination
enzyme inhibition
long term memory
male
memory consolidation
molecular dynamics
mouse
nonhuman
priority journal
protein analysis
protein function
reinforcement
transcription initiation
spellingShingle calcineurin
immunoglobulin enhancer binding protein
transcription factor NFAT
amino acid sequence
animal experiment
animal tissue
article
controlled study
DNA determination
enzyme inhibition
long term memory
male
memory consolidation
molecular dynamics
mouse
nonhuman
priority journal
protein analysis
protein function
reinforcement
transcription initiation
de la Fuente, V.
Freudenthal, R.
Romano, A.
Reconsolidation or extinction: Transcription factor switch in the determination of memory course after retrieval
topic_facet calcineurin
immunoglobulin enhancer binding protein
transcription factor NFAT
amino acid sequence
animal experiment
animal tissue
article
controlled study
DNA determination
enzyme inhibition
long term memory
male
memory consolidation
molecular dynamics
mouse
nonhuman
priority journal
protein analysis
protein function
reinforcement
transcription initiation
description In fear conditioning, aversive stimuli are readily associated with contextual features. A brief reexposure to the training context causes fear memory reconsolidation, whereas a prolonged re exposure induces memory extinction. The regulation of hippocampal gene expression plays akey role in contextual memory consolidation and reconsolidation. However, the mechanisms that determine whether memory will reconsolidate or extinguish are not known. Here, we demonstrate opposing roles for two evolutionarily related transcription factors in the mouse hippocampus. We found that nuclear factor-KB (NF-kB) is required for fear memory reconsolidation. Conversely, calcineurin phosphatase inhibited NF-kB and induced nuclear factor of activated T-cells (NFAT) nuclear translocation in the transition between reconsolidation and extinction. Accordingly, the hippocampal inhibition of both calcineurin and NFAT independently impaired memory extinction, whereas inhibition of NF-kB enhanced memory extinction. These findings represent the first insight into the molecular mechanisms that determine memory reprocessing after retrieval, supporting a transcriptional switch that directs memory toward reconsolidation or extinction. The precise molecular characterization of postretrieval processes has potential importance to the development of therapeutic strategies for fear memory disorders. © 2011 the authors.
format Artículo
Artículo
publishedVersion
author de la Fuente, V.
Freudenthal, R.
Romano, A.
author_facet de la Fuente, V.
Freudenthal, R.
Romano, A.
author_sort de la Fuente, V.
title Reconsolidation or extinction: Transcription factor switch in the determination of memory course after retrieval
title_short Reconsolidation or extinction: Transcription factor switch in the determination of memory course after retrieval
title_full Reconsolidation or extinction: Transcription factor switch in the determination of memory course after retrieval
title_fullStr Reconsolidation or extinction: Transcription factor switch in the determination of memory course after retrieval
title_full_unstemmed Reconsolidation or extinction: Transcription factor switch in the determination of memory course after retrieval
title_sort reconsolidation or extinction: transcription factor switch in the determination of memory course after retrieval
publishDate 2011
url http://hdl.handle.net/20.500.12110/paper_02706474_v31_n15_p5562_delaFuente
https://repositoriouba.sisbi.uba.ar/gsdl/cgi-bin/library.cgi?a=d&c=artiaex&d=paper_02706474_v31_n15_p5562_delaFuente_oai
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AT freudenthalr reconsolidationorextinctiontranscriptionfactorswitchinthedeterminationofmemorycourseafterretrieval
AT romanoa reconsolidationorextinctiontranscriptionfactorswitchinthedeterminationofmemorycourseafterretrieval
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