Mechanism of action of 4-phenoxyphenoxyethyl thiocyanate (WC-9) against Trypanosoma cruzi, the causative agent of Chagas' disease
We investigated the molecular basis of the activity of 4-phenoxyphenoxyethyl thiocyanate (WC-9) against Trypanosoma cruzi, the etiological agent of Chagas' disease. We found that growth inhibition of T. cruzi epimastigotes induced by this compound was associated with a reduction in the content...
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Acceso en línea: | http://hdl.handle.net/20.500.12110/paper_00664804_v47_n6_p2047_Urbina http://repositoriouba.sisbi.uba.ar/gsdl/cgi-bin/library.cgi?a=d&c=artiaex&d=paper_00664804_v47_n6_p2047_Urbina_oai |
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I28-R145-paper_00664804_v47_n6_p2047_Urbina_oai2020-10-19 Urbina, J.A. Concepcion, J.L. Montalvetti, A. Rodriguez, J.B. Docampo, R. 2003 We investigated the molecular basis of the activity of 4-phenoxyphenoxyethyl thiocyanate (WC-9) against Trypanosoma cruzi, the etiological agent of Chagas' disease. We found that growth inhibition of T. cruzi epimastigotes induced by this compound was associated with a reduction in the content of the parasite's endogenous sterols due to a specific blockade of their de novo synthesis at the level of squalene synthase. Fil:Rodriguez, J.B. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. application/pdf http://hdl.handle.net/20.500.12110/paper_00664804_v47_n6_p2047_Urbina info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar Antimicrob. Agents Chemother. 2003;47(6):2047-2050 4 phenoxyphenoxyethyl thiocyanate antiprotozoal agent squalene synthase sterol unclassified drug wc 9 antiprotozoal activity article Chagas disease controlled study drug activity drug mechanism epimastigote growth inhibition nonhuman priority journal sterol synthesis Trypanosoma cruzi Alkyl and Aryl Transferases Animals Dose-Response Relationship, Drug Ergosterol Farnesyl-Diphosphate Farnesyltransferase Geranyltranstransferase Humans Microbial Sensitivity Tests Phenyl Ethers Thiocyanates Trypanocidal Agents Trypanosoma cruzi Mechanism of action of 4-phenoxyphenoxyethyl thiocyanate (WC-9) against Trypanosoma cruzi, the causative agent of Chagas' disease info:eu-repo/semantics/article info:ar-repo/semantics/artículo info:eu-repo/semantics/publishedVersion http://repositoriouba.sisbi.uba.ar/gsdl/cgi-bin/library.cgi?a=d&c=artiaex&d=paper_00664804_v47_n6_p2047_Urbina_oai |
institution |
Universidad de Buenos Aires |
institution_str |
I-28 |
repository_str |
R-145 |
collection |
Repositorio Digital de la Universidad de Buenos Aires (UBA) |
topic |
4 phenoxyphenoxyethyl thiocyanate antiprotozoal agent squalene synthase sterol unclassified drug wc 9 antiprotozoal activity article Chagas disease controlled study drug activity drug mechanism epimastigote growth inhibition nonhuman priority journal sterol synthesis Trypanosoma cruzi Alkyl and Aryl Transferases Animals Dose-Response Relationship, Drug Ergosterol Farnesyl-Diphosphate Farnesyltransferase Geranyltranstransferase Humans Microbial Sensitivity Tests Phenyl Ethers Thiocyanates Trypanocidal Agents Trypanosoma cruzi |
spellingShingle |
4 phenoxyphenoxyethyl thiocyanate antiprotozoal agent squalene synthase sterol unclassified drug wc 9 antiprotozoal activity article Chagas disease controlled study drug activity drug mechanism epimastigote growth inhibition nonhuman priority journal sterol synthesis Trypanosoma cruzi Alkyl and Aryl Transferases Animals Dose-Response Relationship, Drug Ergosterol Farnesyl-Diphosphate Farnesyltransferase Geranyltranstransferase Humans Microbial Sensitivity Tests Phenyl Ethers Thiocyanates Trypanocidal Agents Trypanosoma cruzi Urbina, J.A. Concepcion, J.L. Montalvetti, A. Rodriguez, J.B. Docampo, R. Mechanism of action of 4-phenoxyphenoxyethyl thiocyanate (WC-9) against Trypanosoma cruzi, the causative agent of Chagas' disease |
topic_facet |
4 phenoxyphenoxyethyl thiocyanate antiprotozoal agent squalene synthase sterol unclassified drug wc 9 antiprotozoal activity article Chagas disease controlled study drug activity drug mechanism epimastigote growth inhibition nonhuman priority journal sterol synthesis Trypanosoma cruzi Alkyl and Aryl Transferases Animals Dose-Response Relationship, Drug Ergosterol Farnesyl-Diphosphate Farnesyltransferase Geranyltranstransferase Humans Microbial Sensitivity Tests Phenyl Ethers Thiocyanates Trypanocidal Agents Trypanosoma cruzi |
description |
We investigated the molecular basis of the activity of 4-phenoxyphenoxyethyl thiocyanate (WC-9) against Trypanosoma cruzi, the etiological agent of Chagas' disease. We found that growth inhibition of T. cruzi epimastigotes induced by this compound was associated with a reduction in the content of the parasite's endogenous sterols due to a specific blockade of their de novo synthesis at the level of squalene synthase. |
format |
Artículo Artículo publishedVersion |
author |
Urbina, J.A. Concepcion, J.L. Montalvetti, A. Rodriguez, J.B. Docampo, R. |
author_facet |
Urbina, J.A. Concepcion, J.L. Montalvetti, A. Rodriguez, J.B. Docampo, R. |
author_sort |
Urbina, J.A. |
title |
Mechanism of action of 4-phenoxyphenoxyethyl thiocyanate (WC-9) against Trypanosoma cruzi, the causative agent of Chagas' disease |
title_short |
Mechanism of action of 4-phenoxyphenoxyethyl thiocyanate (WC-9) against Trypanosoma cruzi, the causative agent of Chagas' disease |
title_full |
Mechanism of action of 4-phenoxyphenoxyethyl thiocyanate (WC-9) against Trypanosoma cruzi, the causative agent of Chagas' disease |
title_fullStr |
Mechanism of action of 4-phenoxyphenoxyethyl thiocyanate (WC-9) against Trypanosoma cruzi, the causative agent of Chagas' disease |
title_full_unstemmed |
Mechanism of action of 4-phenoxyphenoxyethyl thiocyanate (WC-9) against Trypanosoma cruzi, the causative agent of Chagas' disease |
title_sort |
mechanism of action of 4-phenoxyphenoxyethyl thiocyanate (wc-9) against trypanosoma cruzi, the causative agent of chagas' disease |
publishDate |
2003 |
url |
http://hdl.handle.net/20.500.12110/paper_00664804_v47_n6_p2047_Urbina http://repositoriouba.sisbi.uba.ar/gsdl/cgi-bin/library.cgi?a=d&c=artiaex&d=paper_00664804_v47_n6_p2047_Urbina_oai |
work_keys_str_mv |
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1766026633158852608 |