Mechanism of action of 4-phenoxyphenoxyethyl thiocyanate (WC-9) against Trypanosoma cruzi, the causative agent of Chagas' disease

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We investigated the molecular basis of the activity of 4-phenoxyphenoxyethyl thiocyanate (WC-9) against Trypanosoma cruzi, the etiological agent of Chagas' disease. We found that growth inhibition of T. cruzi epimastigotes induced by this compound was associated with a reduction in the content...

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Autores principales:	Urbina, J.A., Concepcion, J.L., Montalvetti, A., Rodriguez, J.B., Docampo, R.
Formato:	Artículo publishedVersion
Publicado:	2003
Materias:	4 phenoxyphenoxyethyl thiocyanate antiprotozoal agent squalene synthase sterol unclassified drug wc 9 antiprotozoal activity article Chagas disease controlled study drug activity drug mechanism epimastigote growth inhibition nonhuman priority journal sterol synthesis Trypanosoma cruzi Alkyl and Aryl Transferases Animals Dose-Response Relationship, Drug Ergosterol Farnesyl-Diphosphate Farnesyltransferase Geranyltranstransferase Humans Microbial Sensitivity Tests Phenyl Ethers Thiocyanates Trypanocidal Agents
Acceso en línea:	http://hdl.handle.net/20.500.12110/paper_00664804_v47_n6_p2047_Urbina http://repositoriouba.sisbi.uba.ar/gsdl/cgi-bin/library.cgi?a=d&c=artiaex&d=paper_00664804_v47_n6_p2047_Urbina_oai
Aporte de:	Repositorio Digital de la Universidad de Buenos Aires (UBA) de Universidad de Buenos Aires

id	I28-R145-paper_00664804_v47_n6_p2047_Urbina_oai
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spelling	I28-R145-paper_00664804_v47_n6_p2047_Urbina_oai2020-10-19 Urbina, J.A. Concepcion, J.L. Montalvetti, A. Rodriguez, J.B. Docampo, R. 2003 We investigated the molecular basis of the activity of 4-phenoxyphenoxyethyl thiocyanate (WC-9) against Trypanosoma cruzi, the etiological agent of Chagas' disease. We found that growth inhibition of T. cruzi epimastigotes induced by this compound was associated with a reduction in the content of the parasite's endogenous sterols due to a specific blockade of their de novo synthesis at the level of squalene synthase. Fil:Rodriguez, J.B. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. application/pdf http://hdl.handle.net/20.500.12110/paper_00664804_v47_n6_p2047_Urbina info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar Antimicrob. Agents Chemother. 2003;47(6):2047-2050 4 phenoxyphenoxyethyl thiocyanate antiprotozoal agent squalene synthase sterol unclassified drug wc 9 antiprotozoal activity article Chagas disease controlled study drug activity drug mechanism epimastigote growth inhibition nonhuman priority journal sterol synthesis Trypanosoma cruzi Alkyl and Aryl Transferases Animals Dose-Response Relationship, Drug Ergosterol Farnesyl-Diphosphate Farnesyltransferase Geranyltranstransferase Humans Microbial Sensitivity Tests Phenyl Ethers Thiocyanates Trypanocidal Agents Trypanosoma cruzi Mechanism of action of 4-phenoxyphenoxyethyl thiocyanate (WC-9) against Trypanosoma cruzi, the causative agent of Chagas' disease info:eu-repo/semantics/article info:ar-repo/semantics/artículo info:eu-repo/semantics/publishedVersion http://repositoriouba.sisbi.uba.ar/gsdl/cgi-bin/library.cgi?a=d&c=artiaex&d=paper_00664804_v47_n6_p2047_Urbina_oai
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-145
collection	Repositorio Digital de la Universidad de Buenos Aires (UBA)
topic	4 phenoxyphenoxyethyl thiocyanate antiprotozoal agent squalene synthase sterol unclassified drug wc 9 antiprotozoal activity article Chagas disease controlled study drug activity drug mechanism epimastigote growth inhibition nonhuman priority journal sterol synthesis Trypanosoma cruzi Alkyl and Aryl Transferases Animals Dose-Response Relationship, Drug Ergosterol Farnesyl-Diphosphate Farnesyltransferase Geranyltranstransferase Humans Microbial Sensitivity Tests Phenyl Ethers Thiocyanates Trypanocidal Agents Trypanosoma cruzi
spellingShingle	4 phenoxyphenoxyethyl thiocyanate antiprotozoal agent squalene synthase sterol unclassified drug wc 9 antiprotozoal activity article Chagas disease controlled study drug activity drug mechanism epimastigote growth inhibition nonhuman priority journal sterol synthesis Trypanosoma cruzi Alkyl and Aryl Transferases Animals Dose-Response Relationship, Drug Ergosterol Farnesyl-Diphosphate Farnesyltransferase Geranyltranstransferase Humans Microbial Sensitivity Tests Phenyl Ethers Thiocyanates Trypanocidal Agents Trypanosoma cruzi Urbina, J.A. Concepcion, J.L. Montalvetti, A. Rodriguez, J.B. Docampo, R. Mechanism of action of 4-phenoxyphenoxyethyl thiocyanate (WC-9) against Trypanosoma cruzi, the causative agent of Chagas' disease
topic_facet	4 phenoxyphenoxyethyl thiocyanate antiprotozoal agent squalene synthase sterol unclassified drug wc 9 antiprotozoal activity article Chagas disease controlled study drug activity drug mechanism epimastigote growth inhibition nonhuman priority journal sterol synthesis Trypanosoma cruzi Alkyl and Aryl Transferases Animals Dose-Response Relationship, Drug Ergosterol Farnesyl-Diphosphate Farnesyltransferase Geranyltranstransferase Humans Microbial Sensitivity Tests Phenyl Ethers Thiocyanates Trypanocidal Agents Trypanosoma cruzi
description	We investigated the molecular basis of the activity of 4-phenoxyphenoxyethyl thiocyanate (WC-9) against Trypanosoma cruzi, the etiological agent of Chagas' disease. We found that growth inhibition of T. cruzi epimastigotes induced by this compound was associated with a reduction in the content of the parasite's endogenous sterols due to a specific blockade of their de novo synthesis at the level of squalene synthase.
format	Artículo Artículo publishedVersion
author	Urbina, J.A. Concepcion, J.L. Montalvetti, A. Rodriguez, J.B. Docampo, R.
author_facet	Urbina, J.A. Concepcion, J.L. Montalvetti, A. Rodriguez, J.B. Docampo, R.
author_sort	Urbina, J.A.
title	Mechanism of action of 4-phenoxyphenoxyethyl thiocyanate (WC-9) against Trypanosoma cruzi, the causative agent of Chagas' disease
title_short	Mechanism of action of 4-phenoxyphenoxyethyl thiocyanate (WC-9) against Trypanosoma cruzi, the causative agent of Chagas' disease
title_full	Mechanism of action of 4-phenoxyphenoxyethyl thiocyanate (WC-9) against Trypanosoma cruzi, the causative agent of Chagas' disease
title_fullStr	Mechanism of action of 4-phenoxyphenoxyethyl thiocyanate (WC-9) against Trypanosoma cruzi, the causative agent of Chagas' disease
title_full_unstemmed	Mechanism of action of 4-phenoxyphenoxyethyl thiocyanate (WC-9) against Trypanosoma cruzi, the causative agent of Chagas' disease
title_sort	mechanism of action of 4-phenoxyphenoxyethyl thiocyanate (wc-9) against trypanosoma cruzi, the causative agent of chagas' disease
publishDate	2003
url	http://hdl.handle.net/20.500.12110/paper_00664804_v47_n6_p2047_Urbina http://repositoriouba.sisbi.uba.ar/gsdl/cgi-bin/library.cgi?a=d&c=artiaex&d=paper_00664804_v47_n6_p2047_Urbina_oai
work_keys_str_mv	AT urbinaja mechanismofactionof4phenoxyphenoxyethylthiocyanatewc9againsttrypanosomacruzithecausativeagentofchagasdisease AT concepcionjl mechanismofactionof4phenoxyphenoxyethylthiocyanatewc9againsttrypanosomacruzithecausativeagentofchagasdisease AT montalvettia mechanismofactionof4phenoxyphenoxyethylthiocyanatewc9againsttrypanosomacruzithecausativeagentofchagasdisease AT rodriguezjb mechanismofactionof4phenoxyphenoxyethylthiocyanatewc9againsttrypanosomacruzithecausativeagentofchagasdisease AT docampor mechanismofactionof4phenoxyphenoxyethylthiocyanatewc9againsttrypanosomacruzithecausativeagentofchagasdisease
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Mechanism of action of 4-phenoxyphenoxyethyl thiocyanate (WC-9) against Trypanosoma cruzi, the causative agent of Chagas' disease

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