Behavioral tagging is a general mechanism of long-term memory formation

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In daily life, memories are intertwined events. Little is known about the mechanisms involved in their interactions. Using two hippocampus-dependent (spatial object recognition and contextual fear conditioning) and one hippocampus-independent (conditioned taste aversion) learning tasks, we show that...

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Autores principales:	Ballarini, F., Moncada, D., Martinez, M.C., Alen, N., Viola, H.
Formato:	Artículo publishedVersion
Publicado:	2009
Materias:	Hippocampus Insular cortex Memory consolidation Novelty Protein synthesis animal experiment article behavior conditioned reflex conditioning controlled study hippocampus learning long term memory male nonhuman open field behavior priority journal protein synthesis rat recognition short term memory task performance taste aversion training Animals Behavior, Animal Conditioning (Psychology) Discrimination Learning Fear Learning Long-Term Potentiation Male Memory Memory, Short-Term Neocortex Neuronal Plasticity Psychomotor Performance Rats Rats, Wistar Saccharin Sodium Chloride Spatial Behavior Taste Time Factors Rattus
Acceso en línea:	http://hdl.handle.net/20.500.12110/paper_00278424_v106_n34_p14599_Ballarini http://repositoriouba.sisbi.uba.ar/gsdl/cgi-bin/library.cgi?a=d&c=artiaex&d=paper_00278424_v106_n34_p14599_Ballarini_oai
Aporte de:	Repositorio Digital de la Universidad de Buenos Aires (UBA) de Universidad de Buenos Aires

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spelling	I28-R145-paper_00278424_v106_n34_p14599_Ballarini_oai2020-10-19 Ballarini, F. Moncada, D. Martinez, M.C. Alen, N. Viola, H. 2009 In daily life, memories are intertwined events. Little is known about the mechanisms involved in their interactions. Using two hippocampus-dependent (spatial object recognition and contextual fear conditioning) and one hippocampus-independent (conditioned taste aversion) learning tasks, we show that in rats subjected to weak training protocols that induce solely short term memory (STM), long term memory (LTM) is promoted and formed only if training sessions took place in contingence with a novel, but not familiar, experience occurring during a critical time window around training. This process requires newly synthesized proteins induced by novelty and reveals a general mechanism of LTM formation that begins with the setting of a "learning tag" established by a weak training. These findings represent the first comprehensive set of evidences indicating the existence of a behavioral tagging process that in analogy to the synaptic tagging and capture process, need the creation of a transient, protein synthesis-independent, and input specific tag. Fil:Moncada, D. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Martinez, M.C. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Alen, N. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Viola, H. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. application/pdf http://hdl.handle.net/20.500.12110/paper_00278424_v106_n34_p14599_Ballarini info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar Proc. Natl. Acad. Sci. U. S. A. 2009;106(34):14599-14604 Hippocampus Insular cortex Memory consolidation Novelty Protein synthesis animal experiment article behavior conditioned reflex conditioning controlled study hippocampus learning long term memory male nonhuman open field behavior priority journal protein synthesis rat recognition short term memory task performance taste aversion training Animals Behavior, Animal Conditioning (Psychology) Discrimination Learning Fear Hippocampus Learning Long-Term Potentiation Male Memory Memory, Short-Term Neocortex Neuronal Plasticity Psychomotor Performance Rats Rats, Wistar Saccharin Sodium Chloride Spatial Behavior Taste Time Factors Rattus Behavioral tagging is a general mechanism of long-term memory formation info:eu-repo/semantics/article info:ar-repo/semantics/artículo info:eu-repo/semantics/publishedVersion http://repositoriouba.sisbi.uba.ar/gsdl/cgi-bin/library.cgi?a=d&c=artiaex&d=paper_00278424_v106_n34_p14599_Ballarini_oai
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-145
collection	Repositorio Digital de la Universidad de Buenos Aires (UBA)
topic	Hippocampus Insular cortex Memory consolidation Novelty Protein synthesis animal experiment article behavior conditioned reflex conditioning controlled study hippocampus learning long term memory male nonhuman open field behavior priority journal protein synthesis rat recognition short term memory task performance taste aversion training Animals Behavior, Animal Conditioning (Psychology) Discrimination Learning Fear Hippocampus Learning Long-Term Potentiation Male Memory Memory, Short-Term Neocortex Neuronal Plasticity Psychomotor Performance Rats Rats, Wistar Saccharin Sodium Chloride Spatial Behavior Taste Time Factors Rattus
spellingShingle	Hippocampus Insular cortex Memory consolidation Novelty Protein synthesis animal experiment article behavior conditioned reflex conditioning controlled study hippocampus learning long term memory male nonhuman open field behavior priority journal protein synthesis rat recognition short term memory task performance taste aversion training Animals Behavior, Animal Conditioning (Psychology) Discrimination Learning Fear Hippocampus Learning Long-Term Potentiation Male Memory Memory, Short-Term Neocortex Neuronal Plasticity Psychomotor Performance Rats Rats, Wistar Saccharin Sodium Chloride Spatial Behavior Taste Time Factors Rattus Ballarini, F. Moncada, D. Martinez, M.C. Alen, N. Viola, H. Behavioral tagging is a general mechanism of long-term memory formation
topic_facet	Hippocampus Insular cortex Memory consolidation Novelty Protein synthesis animal experiment article behavior conditioned reflex conditioning controlled study hippocampus learning long term memory male nonhuman open field behavior priority journal protein synthesis rat recognition short term memory task performance taste aversion training Animals Behavior, Animal Conditioning (Psychology) Discrimination Learning Fear Hippocampus Learning Long-Term Potentiation Male Memory Memory, Short-Term Neocortex Neuronal Plasticity Psychomotor Performance Rats Rats, Wistar Saccharin Sodium Chloride Spatial Behavior Taste Time Factors Rattus
description	In daily life, memories are intertwined events. Little is known about the mechanisms involved in their interactions. Using two hippocampus-dependent (spatial object recognition and contextual fear conditioning) and one hippocampus-independent (conditioned taste aversion) learning tasks, we show that in rats subjected to weak training protocols that induce solely short term memory (STM), long term memory (LTM) is promoted and formed only if training sessions took place in contingence with a novel, but not familiar, experience occurring during a critical time window around training. This process requires newly synthesized proteins induced by novelty and reveals a general mechanism of LTM formation that begins with the setting of a "learning tag" established by a weak training. These findings represent the first comprehensive set of evidences indicating the existence of a behavioral tagging process that in analogy to the synaptic tagging and capture process, need the creation of a transient, protein synthesis-independent, and input specific tag.
format	Artículo Artículo publishedVersion
author	Ballarini, F. Moncada, D. Martinez, M.C. Alen, N. Viola, H.
author_facet	Ballarini, F. Moncada, D. Martinez, M.C. Alen, N. Viola, H.
author_sort	Ballarini, F.
title	Behavioral tagging is a general mechanism of long-term memory formation
title_short	Behavioral tagging is a general mechanism of long-term memory formation
title_full	Behavioral tagging is a general mechanism of long-term memory formation
title_fullStr	Behavioral tagging is a general mechanism of long-term memory formation
title_full_unstemmed	Behavioral tagging is a general mechanism of long-term memory formation
title_sort	behavioral tagging is a general mechanism of long-term memory formation
publishDate	2009
url	http://hdl.handle.net/20.500.12110/paper_00278424_v106_n34_p14599_Ballarini http://repositoriouba.sisbi.uba.ar/gsdl/cgi-bin/library.cgi?a=d&c=artiaex&d=paper_00278424_v106_n34_p14599_Ballarini_oai
work_keys_str_mv	AT ballarinif behavioraltaggingisageneralmechanismoflongtermmemoryformation AT moncadad behavioraltaggingisageneralmechanismoflongtermmemoryformation AT martinezmc behavioraltaggingisageneralmechanismoflongtermmemoryformation AT alenn behavioraltaggingisageneralmechanismoflongtermmemoryformation AT violah behavioraltaggingisageneralmechanismoflongtermmemoryformation
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Behavioral tagging is a general mechanism of long-term memory formation

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