Effect of some antineoplasics on metabolic heme pathway
1. 1. The porphyrinogenic ability of several antineoplasics used in the therapy of the different cancers was evaluated. The action of cyclophosphamide, busulfan and 5-fluorouracil on the amount and nature of the accumulated hepatic porphyrins and on the activity of δ-aminolaevulinate synthase(ALA-S)...
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1988
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| Acceso en línea: | http://hdl.handle.net/20.500.12110/paper_0020711X_v20_n9_p1015_WainstokDeCalmanovici http://repositoriouba.sisbi.uba.ar/gsdl/cgi-bin/library.cgi?a=d&c=artiaex&d=paper_0020711X_v20_n9_p1015_WainstokDeCalmanovici_oai |
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I28-R145-paper_0020711X_v20_n9_p1015_WainstokDeCalmanovici_oai2020-10-19 Wainstok De Calmanovici, R. San Martin De Viale, L.C. 1988 1. 1. The porphyrinogenic ability of several antineoplasics used in the therapy of the different cancers was evaluated. The action of cyclophosphamide, busulfan and 5-fluorouracil on the amount and nature of the accumulated hepatic porphyrins and on the activity of δ-aminolaevulinate synthase(ALA-S). were estimated at different doses and times of drug treatment in 17-day-old chick embryos. 2. 2. It was observed that cyclophosphamide produces a significant increase in the accumulation of hepatic porphyrins at different doses as well as in the activity of the ALA-S, at all the incubation times. Cyclophosphamide alters the pattern of porphyrins accumulated in the liver, where a coproporphyrin: protoporphyrin ratio higher than in the controls can be observed. 3. 3. Busulfan increased the hepatic porphyrins accumulated in the liver but to a lesser degree than cyclophosphamide. 4. 4. 5-Fluorouracil did not modify the hepatic porphyrin content when it was administered at doses up to 40 mg/embryo. 5. 5. When the embryos were injected with busulfan or 5-fluorouracil no significant differences were observed in the activity of ALA-S up to 11 hr of incubation. 6. 6. These results indicate that cyclophosphamide has a remarkable porphyrinogenic capacity in chick embryo while busulfan. notwithstancling the fact that it alters the haem pathway, it does so to a degree that does not impair the regulation of ALA-S activity. Fluorouracil seems to be non porphyrinogenic in this system, up to 40 mg/embryo. © 1988. Fil:Wainstok De Calmanovici, R. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:San Martin De Viale, L.C. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. application/pdf http://hdl.handle.net/20.500.12110/paper_0020711X_v20_n9_p1015_WainstokDeCalmanovici info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar Int. J. Biochem. 1988;20(9):1015-1020 5 aminolevulinate synthase antineoplastic agent busulfan cyclophosphamide fluorouracil heme porphyrin 5 aminolevulinate synthase busulfan cyclophosphamide fluorouracil porphyrin animal article chick embryo drug effect liver metabolism chicken nonhuman porphyrin synthesis 5-Aminolevulinate Synthetase Animal Antineoplastic Agents Busulfan Chick Embryo Cyclophosphamide Fluorouracil Heme Liver Porphyrins Support, Non-U.S. Gov't Effect of some antineoplasics on metabolic heme pathway info:eu-repo/semantics/article info:ar-repo/semantics/artículo info:eu-repo/semantics/publishedVersion http://repositoriouba.sisbi.uba.ar/gsdl/cgi-bin/library.cgi?a=d&c=artiaex&d=paper_0020711X_v20_n9_p1015_WainstokDeCalmanovici_oai |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-145 |
| collection |
Repositorio Digital de la Universidad de Buenos Aires (UBA) |
| topic |
5 aminolevulinate synthase antineoplastic agent busulfan cyclophosphamide fluorouracil heme porphyrin 5 aminolevulinate synthase busulfan cyclophosphamide fluorouracil porphyrin animal article chick embryo drug effect liver metabolism chicken nonhuman porphyrin synthesis 5-Aminolevulinate Synthetase Animal Antineoplastic Agents Busulfan Chick Embryo Cyclophosphamide Fluorouracil Heme Liver Porphyrins Support, Non-U.S. Gov't |
| spellingShingle |
5 aminolevulinate synthase antineoplastic agent busulfan cyclophosphamide fluorouracil heme porphyrin 5 aminolevulinate synthase busulfan cyclophosphamide fluorouracil porphyrin animal article chick embryo drug effect liver metabolism chicken nonhuman porphyrin synthesis 5-Aminolevulinate Synthetase Animal Antineoplastic Agents Busulfan Chick Embryo Cyclophosphamide Fluorouracil Heme Liver Porphyrins Support, Non-U.S. Gov't Wainstok De Calmanovici, R. San Martin De Viale, L.C. Effect of some antineoplasics on metabolic heme pathway |
| topic_facet |
5 aminolevulinate synthase antineoplastic agent busulfan cyclophosphamide fluorouracil heme porphyrin 5 aminolevulinate synthase busulfan cyclophosphamide fluorouracil porphyrin animal article chick embryo drug effect liver metabolism chicken nonhuman porphyrin synthesis 5-Aminolevulinate Synthetase Animal Antineoplastic Agents Busulfan Chick Embryo Cyclophosphamide Fluorouracil Heme Liver Porphyrins Support, Non-U.S. Gov't |
| description |
1. 1. The porphyrinogenic ability of several antineoplasics used in the therapy of the different cancers was evaluated. The action of cyclophosphamide, busulfan and 5-fluorouracil on the amount and nature of the accumulated hepatic porphyrins and on the activity of δ-aminolaevulinate synthase(ALA-S). were estimated at different doses and times of drug treatment in 17-day-old chick embryos. 2. 2. It was observed that cyclophosphamide produces a significant increase in the accumulation of hepatic porphyrins at different doses as well as in the activity of the ALA-S, at all the incubation times. Cyclophosphamide alters the pattern of porphyrins accumulated in the liver, where a coproporphyrin: protoporphyrin ratio higher than in the controls can be observed. 3. 3. Busulfan increased the hepatic porphyrins accumulated in the liver but to a lesser degree than cyclophosphamide. 4. 4. 5-Fluorouracil did not modify the hepatic porphyrin content when it was administered at doses up to 40 mg/embryo. 5. 5. When the embryos were injected with busulfan or 5-fluorouracil no significant differences were observed in the activity of ALA-S up to 11 hr of incubation. 6. 6. These results indicate that cyclophosphamide has a remarkable porphyrinogenic capacity in chick embryo while busulfan. notwithstancling the fact that it alters the haem pathway, it does so to a degree that does not impair the regulation of ALA-S activity. Fluorouracil seems to be non porphyrinogenic in this system, up to 40 mg/embryo. © 1988. |
| format |
Artículo Artículo publishedVersion |
| author |
Wainstok De Calmanovici, R. San Martin De Viale, L.C. |
| author_facet |
Wainstok De Calmanovici, R. San Martin De Viale, L.C. |
| author_sort |
Wainstok De Calmanovici, R. |
| title |
Effect of some antineoplasics on metabolic heme pathway |
| title_short |
Effect of some antineoplasics on metabolic heme pathway |
| title_full |
Effect of some antineoplasics on metabolic heme pathway |
| title_fullStr |
Effect of some antineoplasics on metabolic heme pathway |
| title_full_unstemmed |
Effect of some antineoplasics on metabolic heme pathway |
| title_sort |
effect of some antineoplasics on metabolic heme pathway |
| publishDate |
1988 |
| url |
http://hdl.handle.net/20.500.12110/paper_0020711X_v20_n9_p1015_WainstokDeCalmanovici http://repositoriouba.sisbi.uba.ar/gsdl/cgi-bin/library.cgi?a=d&c=artiaex&d=paper_0020711X_v20_n9_p1015_WainstokDeCalmanovici_oai |
| work_keys_str_mv |
AT wainstokdecalmanovicir effectofsomeantineoplasicsonmetabolichemepathway AT sanmartindevialelc effectofsomeantineoplasicsonmetabolichemepathway |
| _version_ |
1766026539238948864 |