Liver porphyrinogen carboxylyase in hexachlorobenzene porphyric rats. Studies with intermediate porphyrinogens of series III and with uroporphyrinogen I

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1. 1. The present work studies the action of hexachlorobenzene (HCB) on the decarboxylation of uroporphyrinogen (Urogen) I and III and also on the decarboxylation of intermediate porphyrinogens of series III under different conditions using liver of normal and porphyric rats as enzyme source. 2. 2....

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Autores principales: Rios de Molina del, M.C., Wainstok de Calmanovici, R., San Martin de Viale, L.C.
Formato: Artículo publishedVersion
Publicado: 1987
Materias:
hexachlorobenzene
uroporphyrinogen decarboxylase
animal model
liver
nonhuman
porphyria
rat
Animal
Carboxy-Lyases
Chlorobenzenes
Female
Hexachlorobenzene
Liver
Porphyria
Porphyrinogens
Rats
Rats, Inbred Strains
Support, Non-U.S. Gov't
Uroporphyrinogen Decarboxylase
Uroporphyrinogens
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_0020711X_v19_n4_p365_RiosdeMolinadel
http://repositoriouba.sisbi.uba.ar/gsdl/cgi-bin/library.cgi?a=d&c=artiaex&d=paper_0020711X_v19_n4_p365_RiosdeMolinadel_oai
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Repositorio Digital de la Universidad de Buenos Aires (UBA) de Universidad de Buenos Aires
id I28-R145-paper_0020711X_v19_n4_p365_RiosdeMolinadel_oai
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spelling I28-R145-paper_0020711X_v19_n4_p365_RiosdeMolinadel_oai2020-10-19 Rios de Molina del, M.C. Wainstok de Calmanovici, R. San Martin de Viale, L.C. 1987 1. 1. The present work studies the action of hexachlorobenzene (HCB) on the decarboxylation of uroporphyrinogen (Urogen) I and III and also on the decarboxylation of intermediate porphyrinogens of series III under different conditions using liver of normal and porphyric rats as enzyme source. 2. 2. The same enzyme is involved in the Urogen decarboxylation of both isomeric series I and III and catalyses the four steps in both cases. HCB affects all of them. 3. 3. HCB blocks the four steps of Urogen III decarboxylation to the same degree, as a function of intoxication time. 4. 4. HCB leads, in general, to an increase in the efficiency (Km/Vmax) of the porphyric system. These data can be interpreted as a reaction of the organism to overcome the enzymatic blockade. © 1987. Fil:Rios de Molina del, M.C. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Wainstok de Calmanovici, R. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:San Martin de Viale, L.C. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. application/pdf http://hdl.handle.net/20.500.12110/paper_0020711X_v19_n4_p365_RiosdeMolinadel info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar Int. J. Biochem. 1987;19(4):365-372 hexachlorobenzene uroporphyrinogen decarboxylase animal model liver nonhuman porphyria rat Animal Carboxy-Lyases Chlorobenzenes Female Hexachlorobenzene Liver Porphyria Porphyrinogens Rats Rats, Inbred Strains Support, Non-U.S. Gov't Uroporphyrinogen Decarboxylase Uroporphyrinogens Liver porphyrinogen carboxylyase in hexachlorobenzene porphyric rats. Studies with intermediate porphyrinogens of series III and with uroporphyrinogen I info:eu-repo/semantics/article info:ar-repo/semantics/artículo info:eu-repo/semantics/publishedVersion http://repositoriouba.sisbi.uba.ar/gsdl/cgi-bin/library.cgi?a=d&c=artiaex&d=paper_0020711X_v19_n4_p365_RiosdeMolinadel_oai
institution Universidad de Buenos Aires
institution_str I-28
repository_str R-145
collection Repositorio Digital de la Universidad de Buenos Aires (UBA)
topic hexachlorobenzene
uroporphyrinogen decarboxylase
animal model
liver
nonhuman
porphyria
rat
Animal
Carboxy-Lyases
Chlorobenzenes
Female
Hexachlorobenzene
Liver
Porphyria
Porphyrinogens
Rats
Rats, Inbred Strains
Support, Non-U.S. Gov't
Uroporphyrinogen Decarboxylase
Uroporphyrinogens
spellingShingle hexachlorobenzene
uroporphyrinogen decarboxylase
animal model
liver
nonhuman
porphyria
rat
Animal
Carboxy-Lyases
Chlorobenzenes
Female
Hexachlorobenzene
Liver
Porphyria
Porphyrinogens
Rats
Rats, Inbred Strains
Support, Non-U.S. Gov't
Uroporphyrinogen Decarboxylase
Uroporphyrinogens
Rios de Molina del, M.C.
Wainstok de Calmanovici, R.
San Martin de Viale, L.C.
Liver porphyrinogen carboxylyase in hexachlorobenzene porphyric rats. Studies with intermediate porphyrinogens of series III and with uroporphyrinogen I
topic_facet hexachlorobenzene
uroporphyrinogen decarboxylase
animal model
liver
nonhuman
porphyria
rat
Animal
Carboxy-Lyases
Chlorobenzenes
Female
Hexachlorobenzene
Liver
Porphyria
Porphyrinogens
Rats
Rats, Inbred Strains
Support, Non-U.S. Gov't
Uroporphyrinogen Decarboxylase
Uroporphyrinogens
description 1. 1. The present work studies the action of hexachlorobenzene (HCB) on the decarboxylation of uroporphyrinogen (Urogen) I and III and also on the decarboxylation of intermediate porphyrinogens of series III under different conditions using liver of normal and porphyric rats as enzyme source. 2. 2. The same enzyme is involved in the Urogen decarboxylation of both isomeric series I and III and catalyses the four steps in both cases. HCB affects all of them. 3. 3. HCB blocks the four steps of Urogen III decarboxylation to the same degree, as a function of intoxication time. 4. 4. HCB leads, in general, to an increase in the efficiency (Km/Vmax) of the porphyric system. These data can be interpreted as a reaction of the organism to overcome the enzymatic blockade. © 1987.
format Artículo
Artículo
publishedVersion
author Rios de Molina del, M.C.
Wainstok de Calmanovici, R.
San Martin de Viale, L.C.
author_facet Rios de Molina del, M.C.
Wainstok de Calmanovici, R.
San Martin de Viale, L.C.
author_sort Rios de Molina del, M.C.
title Liver porphyrinogen carboxylyase in hexachlorobenzene porphyric rats. Studies with intermediate porphyrinogens of series III and with uroporphyrinogen I
title_short Liver porphyrinogen carboxylyase in hexachlorobenzene porphyric rats. Studies with intermediate porphyrinogens of series III and with uroporphyrinogen I
title_full Liver porphyrinogen carboxylyase in hexachlorobenzene porphyric rats. Studies with intermediate porphyrinogens of series III and with uroporphyrinogen I
title_fullStr Liver porphyrinogen carboxylyase in hexachlorobenzene porphyric rats. Studies with intermediate porphyrinogens of series III and with uroporphyrinogen I
title_full_unstemmed Liver porphyrinogen carboxylyase in hexachlorobenzene porphyric rats. Studies with intermediate porphyrinogens of series III and with uroporphyrinogen I
title_sort liver porphyrinogen carboxylyase in hexachlorobenzene porphyric rats. studies with intermediate porphyrinogens of series iii and with uroporphyrinogen i
publishDate 1987
url http://hdl.handle.net/20.500.12110/paper_0020711X_v19_n4_p365_RiosdeMolinadel
http://repositoriouba.sisbi.uba.ar/gsdl/cgi-bin/library.cgi?a=d&c=artiaex&d=paper_0020711X_v19_n4_p365_RiosdeMolinadel_oai
work_keys_str_mv AT riosdemolinadelmc liverporphyrinogencarboxylyaseinhexachlorobenzeneporphyricratsstudieswithintermediateporphyrinogensofseriesiiiandwithuroporphyrinogeni
AT wainstokdecalmanovicir liverporphyrinogencarboxylyaseinhexachlorobenzeneporphyricratsstudieswithintermediateporphyrinogensofseriesiiiandwithuroporphyrinogeni
AT sanmartindevialelc liverporphyrinogencarboxylyaseinhexachlorobenzeneporphyricratsstudieswithintermediateporphyrinogensofseriesiiiandwithuroporphyrinogeni
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