Photodynamic inactivation of red cell uroporphyrinogen decarboxylase by porphyrins
1. 1. The effects of light and porphyrins on the activity of red cell uroporphyrinogen decarboxylase were studied. 2. 2. Photoinactivation of uroporphyrinogen decarboxylase was dependent on uroporphyrin concentration, irradiation time and temperature. Using 40 W/m2 of UV light intensity, 40-45% decr...
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1986
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Acceso en línea: | http://hdl.handle.net/20.500.12110/paper_0020711X_v18_n2_p143_DelCBatlle http://repositoriouba.sisbi.uba.ar/gsdl/cgi-bin/library.cgi?a=d&c=artiaex&d=paper_0020711X_v18_n2_p143_DelCBatlle_oai |
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I28-R145-paper_0020711X_v18_n2_p143_DelCBatlle_oai2020-10-19 Del C. Batlle, A.M. De Salamanca, R.E. Chinarro, S. Afonso, S.G. Stella, A.M. 1986 1. 1. The effects of light and porphyrins on the activity of red cell uroporphyrinogen decarboxylase were studied. 2. 2. Photoinactivation of uroporphyrinogen decarboxylase was dependent on uroporphyrin concentration, irradiation time and temperature. Using 40 W/m2 of UV light intensity, 40-45% decreased activity was produced with 200 μM uroporphyrin I, at 37°C and after 2 hr of illumination. 3. 3. It has been demonstrated that porphyrins photoinactivate uroporphyrinogen decarboxylase and a mechanism for this action in relation to skin lesions is proposed. © 1986. Fil:Del C. Batlle, A.M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Afonso, S.G. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Stella, A.M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. application/pdf http://hdl.handle.net/20.500.12110/paper_0020711X_v18_n2_p143_DelCBatlle info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar Int. J. Biochem. 1986;18(2):143-147 porphyrin uroporphyrinogen decarboxylase blood and hemopoietic system enzyme inactivation erythrocyte human human cell photoactivation Carboxy-Lyases Erythrocytes Humans Kinetics Photolysis Porphyrins Thermodynamics Ultraviolet Rays Uroporphyrinogen Decarboxylase Photodynamic inactivation of red cell uroporphyrinogen decarboxylase by porphyrins info:eu-repo/semantics/article info:ar-repo/semantics/artículo info:eu-repo/semantics/publishedVersion http://repositoriouba.sisbi.uba.ar/gsdl/cgi-bin/library.cgi?a=d&c=artiaex&d=paper_0020711X_v18_n2_p143_DelCBatlle_oai |
institution |
Universidad de Buenos Aires |
institution_str |
I-28 |
repository_str |
R-145 |
collection |
Repositorio Digital de la Universidad de Buenos Aires (UBA) |
topic |
porphyrin uroporphyrinogen decarboxylase blood and hemopoietic system enzyme inactivation erythrocyte human human cell photoactivation Carboxy-Lyases Erythrocytes Humans Kinetics Photolysis Porphyrins Thermodynamics Ultraviolet Rays Uroporphyrinogen Decarboxylase |
spellingShingle |
porphyrin uroporphyrinogen decarboxylase blood and hemopoietic system enzyme inactivation erythrocyte human human cell photoactivation Carboxy-Lyases Erythrocytes Humans Kinetics Photolysis Porphyrins Thermodynamics Ultraviolet Rays Uroporphyrinogen Decarboxylase Del C. Batlle, A.M. De Salamanca, R.E. Chinarro, S. Afonso, S.G. Stella, A.M. Photodynamic inactivation of red cell uroporphyrinogen decarboxylase by porphyrins |
topic_facet |
porphyrin uroporphyrinogen decarboxylase blood and hemopoietic system enzyme inactivation erythrocyte human human cell photoactivation Carboxy-Lyases Erythrocytes Humans Kinetics Photolysis Porphyrins Thermodynamics Ultraviolet Rays Uroporphyrinogen Decarboxylase |
description |
1. 1. The effects of light and porphyrins on the activity of red cell uroporphyrinogen decarboxylase were studied. 2. 2. Photoinactivation of uroporphyrinogen decarboxylase was dependent on uroporphyrin concentration, irradiation time and temperature. Using 40 W/m2 of UV light intensity, 40-45% decreased activity was produced with 200 μM uroporphyrin I, at 37°C and after 2 hr of illumination. 3. 3. It has been demonstrated that porphyrins photoinactivate uroporphyrinogen decarboxylase and a mechanism for this action in relation to skin lesions is proposed. © 1986. |
format |
Artículo Artículo publishedVersion |
author |
Del C. Batlle, A.M. De Salamanca, R.E. Chinarro, S. Afonso, S.G. Stella, A.M. |
author_facet |
Del C. Batlle, A.M. De Salamanca, R.E. Chinarro, S. Afonso, S.G. Stella, A.M. |
author_sort |
Del C. Batlle, A.M. |
title |
Photodynamic inactivation of red cell uroporphyrinogen decarboxylase by porphyrins |
title_short |
Photodynamic inactivation of red cell uroporphyrinogen decarboxylase by porphyrins |
title_full |
Photodynamic inactivation of red cell uroporphyrinogen decarboxylase by porphyrins |
title_fullStr |
Photodynamic inactivation of red cell uroporphyrinogen decarboxylase by porphyrins |
title_full_unstemmed |
Photodynamic inactivation of red cell uroporphyrinogen decarboxylase by porphyrins |
title_sort |
photodynamic inactivation of red cell uroporphyrinogen decarboxylase by porphyrins |
publishDate |
1986 |
url |
http://hdl.handle.net/20.500.12110/paper_0020711X_v18_n2_p143_DelCBatlle http://repositoriouba.sisbi.uba.ar/gsdl/cgi-bin/library.cgi?a=d&c=artiaex&d=paper_0020711X_v18_n2_p143_DelCBatlle_oai |
work_keys_str_mv |
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_version_ |
1766026538307813376 |