Body size in Drosophila: Genetic architecture, allometries and sexual dimorphism

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Even though substantial progress has been made to elucidate the physiological and environmental factors underpinning differences in body size, little is known about its genetic architecture. Furthermore, all animal species bear a specific relationship between the size of each organ and overall body...

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Autores principales:	Carreira, V.P., Mensch, J., Fanara, J.J.
Formato:	Artículo publishedVersion
Publicado:	2009
Materias:	Allometry Body size Drosophila melanogaster Genetic architecture P-element mutagenesis Sexual dimorphism Drosophila protein allometry body size environmental factor evolutionary biology fly genetics mutagenicity sexual dimorphism animal article female gene expression regulation male physiology quantitative trait sexual development Animals Body Size Drosophila Proteins Female Male Mutagenesis, Insertional Quantitative Trait, Heritable Sex Characteristics Animalia
Acceso en línea:	http://hdl.handle.net/20.500.12110/paper_0018067X_v102_n3_p246_Carreira https://repositoriouba.sisbi.uba.ar/gsdl/cgi-bin/library.cgi?a=d&c=artiaex&d=paper_0018067X_v102_n3_p246_Carreira_oai
Aporte de:	Repositorio Digital de la Universidad de Buenos Aires (UBA) de Universidad de Buenos Aires

id	I28-R145-paper_0018067X_v102_n3_p246_Carreira_oai
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spelling	I28-R145-paper_0018067X_v102_n3_p246_Carreira_oai2024-08-16 Carreira, V.P. Mensch, J. Fanara, J.J. 2009 Even though substantial progress has been made to elucidate the physiological and environmental factors underpinning differences in body size, little is known about its genetic architecture. Furthermore, all animal species bear a specific relationship between the size of each organ and overall body size, so different body size traits should be investigated as well as their sexual dimorphism that may have an important impact on the evolution of body size. We have surveyed 191 co-isogenic lines of Drosophila melanogaster, each one of them homozygous for a single P-element insertion, and assessed the effects of mutations on different body size traits compared to the P-element-free co-isogenic control. Nearly 60% of the lines showed significant differences with respect to the control for these traits in one or both sexes and almost 35% showed trait- and sex-specific effects. Candidate gene mutations frequently increased body size in males and decreased it in females. Among the 92 genes identified, most are involved in development and/or metabolic processes and their molecular functions principally include protein-binding and nucleic acid-binding activities. Although several genes showed pleiotropic effects in relation to body size, few of them were involved in the expression of all traits in one or both sexes. These genes seem to be important for different aspects related to the general functioning of the organism. In general, our results indicate that the genetic architecture of body size traits involves a large fraction of the genome and is largely sex and trait specific. © 2009 Macmillan Publishers Limited All rights reserved. Fil:Carreira, V.P. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Mensch, J. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Fanara, J.J. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. application/pdf http://hdl.handle.net/20.500.12110/paper_0018067X_v102_n3_p246_Carreira info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar Heredity 2009;102(3):246-256 Allometry Body size Drosophila melanogaster Genetic architecture P-element mutagenesis Sexual dimorphism Drosophila protein allometry body size environmental factor evolutionary biology fly genetics mutagenicity sexual dimorphism animal article body size Drosophila melanogaster female gene expression regulation genetics male physiology quantitative trait sexual development Animals Body Size Drosophila melanogaster Drosophila Proteins Female Male Mutagenesis, Insertional Quantitative Trait, Heritable Sex Characteristics Animalia Drosophila melanogaster Body size in Drosophila: Genetic architecture, allometries and sexual dimorphism info:eu-repo/semantics/article info:ar-repo/semantics/artículo info:eu-repo/semantics/publishedVersion https://repositoriouba.sisbi.uba.ar/gsdl/cgi-bin/library.cgi?a=d&c=artiaex&d=paper_0018067X_v102_n3_p246_Carreira_oai
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-145
collection	Repositorio Digital de la Universidad de Buenos Aires (UBA)
topic	Allometry Body size Drosophila melanogaster Genetic architecture P-element mutagenesis Sexual dimorphism Drosophila protein allometry body size environmental factor evolutionary biology fly genetics mutagenicity sexual dimorphism animal article body size Drosophila melanogaster female gene expression regulation genetics male physiology quantitative trait sexual development Animals Body Size Drosophila melanogaster Drosophila Proteins Female Male Mutagenesis, Insertional Quantitative Trait, Heritable Sex Characteristics Animalia Drosophila melanogaster
spellingShingle	Allometry Body size Drosophila melanogaster Genetic architecture P-element mutagenesis Sexual dimorphism Drosophila protein allometry body size environmental factor evolutionary biology fly genetics mutagenicity sexual dimorphism animal article body size Drosophila melanogaster female gene expression regulation genetics male physiology quantitative trait sexual development Animals Body Size Drosophila melanogaster Drosophila Proteins Female Male Mutagenesis, Insertional Quantitative Trait, Heritable Sex Characteristics Animalia Drosophila melanogaster Carreira, V.P. Mensch, J. Fanara, J.J. Body size in Drosophila: Genetic architecture, allometries and sexual dimorphism
topic_facet	Allometry Body size Drosophila melanogaster Genetic architecture P-element mutagenesis Sexual dimorphism Drosophila protein allometry body size environmental factor evolutionary biology fly genetics mutagenicity sexual dimorphism animal article body size Drosophila melanogaster female gene expression regulation genetics male physiology quantitative trait sexual development Animals Body Size Drosophila melanogaster Drosophila Proteins Female Male Mutagenesis, Insertional Quantitative Trait, Heritable Sex Characteristics Animalia Drosophila melanogaster
description	Even though substantial progress has been made to elucidate the physiological and environmental factors underpinning differences in body size, little is known about its genetic architecture. Furthermore, all animal species bear a specific relationship between the size of each organ and overall body size, so different body size traits should be investigated as well as their sexual dimorphism that may have an important impact on the evolution of body size. We have surveyed 191 co-isogenic lines of Drosophila melanogaster, each one of them homozygous for a single P-element insertion, and assessed the effects of mutations on different body size traits compared to the P-element-free co-isogenic control. Nearly 60% of the lines showed significant differences with respect to the control for these traits in one or both sexes and almost 35% showed trait- and sex-specific effects. Candidate gene mutations frequently increased body size in males and decreased it in females. Among the 92 genes identified, most are involved in development and/or metabolic processes and their molecular functions principally include protein-binding and nucleic acid-binding activities. Although several genes showed pleiotropic effects in relation to body size, few of them were involved in the expression of all traits in one or both sexes. These genes seem to be important for different aspects related to the general functioning of the organism. In general, our results indicate that the genetic architecture of body size traits involves a large fraction of the genome and is largely sex and trait specific. © 2009 Macmillan Publishers Limited All rights reserved.
format	Artículo Artículo publishedVersion
author	Carreira, V.P. Mensch, J. Fanara, J.J.
author_facet	Carreira, V.P. Mensch, J. Fanara, J.J.
author_sort	Carreira, V.P.
title	Body size in Drosophila: Genetic architecture, allometries and sexual dimorphism
title_short	Body size in Drosophila: Genetic architecture, allometries and sexual dimorphism
title_full	Body size in Drosophila: Genetic architecture, allometries and sexual dimorphism
title_fullStr	Body size in Drosophila: Genetic architecture, allometries and sexual dimorphism
title_full_unstemmed	Body size in Drosophila: Genetic architecture, allometries and sexual dimorphism
title_sort	body size in drosophila: genetic architecture, allometries and sexual dimorphism
publishDate	2009
url	http://hdl.handle.net/20.500.12110/paper_0018067X_v102_n3_p246_Carreira https://repositoriouba.sisbi.uba.ar/gsdl/cgi-bin/library.cgi?a=d&c=artiaex&d=paper_0018067X_v102_n3_p246_Carreira_oai
work_keys_str_mv	AT carreiravp bodysizeindrosophilageneticarchitectureallometriesandsexualdimorphism AT menschj bodysizeindrosophilageneticarchitectureallometriesandsexualdimorphism AT fanarajj bodysizeindrosophilageneticarchitectureallometriesandsexualdimorphism
_version_	1809356961725022208

Body size in Drosophila: Genetic architecture, allometries and sexual dimorphism

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