Coordination between transcription and pre-mRNA processing

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A large body of work has proved that transcription by RNA polymerase II and pre-mRNA processing are coordinated events within the cell nucleus. Capping, splicing and polyadenylation occur while transcription proceeds, suggesting that RNA polymerase II plays a role in the regulation of these events....

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Autores principales: Cramer, P., Srebrow, A., Kadener, S., Werbajh, S., De La Mata, M., Melen, G., Nogués, G., Kornblihtt, A.R.
Formato: Artículo publishedVersion
Publicado: 2001
Materias:
Carboxy-terminal domain
Coupling
mRNA processing
RNA polymerase II
messenger RNA
capping phenomenon
carboxy terminal sequence
cell nucleus
nonhuman
phosphorylation
polyadenylation
priority journal
promoter region
RNA processing
RNA splicing
RNA transcription
short survey
spliceosome
transcription regulation
Humans
Macromolecular Substances
Models, Biological
RNA Polymerase II
RNA Precursors
RNA Processing, Post-Transcriptional
RNA Splicing
Transcription, Genetic
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_00145793_v498_n2-3_p179_Cramer
http://repositoriouba.sisbi.uba.ar/gsdl/cgi-bin/library.cgi?a=d&c=artiaex&d=paper_00145793_v498_n2-3_p179_Cramer_oai
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Repositorio Digital de la Universidad de Buenos Aires (UBA) de Universidad de Buenos Aires
id I28-R145-paper_00145793_v498_n2-3_p179_Cramer_oai
record_format dspace
spelling I28-R145-paper_00145793_v498_n2-3_p179_Cramer_oai2020-10-19 Cramer, P. Srebrow, A. Kadener, S. Werbajh, S. De La Mata, M. Melen, G. Nogués, G. Kornblihtt, A.R. 2001 A large body of work has proved that transcription by RNA polymerase II and pre-mRNA processing are coordinated events within the cell nucleus. Capping, splicing and polyadenylation occur while transcription proceeds, suggesting that RNA polymerase II plays a role in the regulation of these events. The presence and degree of phosphorylation of the carboxy-terminal domain of RNA polymerase II large subunit is important for functioning of the capping enzymes, the assembly of spliceosomes and the binding of the cleavage/polyadenylation complex. Nuclear architecture and gene promoter structure have also been shown to play key roles in coupling between transcription and splicing. © 2001 Published by Elsevier Science B.V. on behalf of the Federation of European Biochemical Societies. Fil:Cramer, P. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Srebrow, A. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Kadener, S. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:De La Mata, M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Melen, G. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Nogués, G. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Kornblihtt, A.R. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. application/pdf http://hdl.handle.net/20.500.12110/paper_00145793_v498_n2-3_p179_Cramer info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar FEBS Lett. 2001;498(2-3):179-182 Carboxy-terminal domain Coupling mRNA processing RNA polymerase II messenger RNA RNA polymerase II capping phenomenon carboxy terminal sequence cell nucleus nonhuman phosphorylation polyadenylation priority journal promoter region RNA processing RNA splicing RNA transcription short survey spliceosome transcription regulation Humans Macromolecular Substances Models, Biological RNA Polymerase II RNA Precursors RNA Processing, Post-Transcriptional RNA Splicing Transcription, Genetic Coordination between transcription and pre-mRNA processing info:eu-repo/semantics/article info:ar-repo/semantics/artículo info:eu-repo/semantics/publishedVersion http://repositoriouba.sisbi.uba.ar/gsdl/cgi-bin/library.cgi?a=d&c=artiaex&d=paper_00145793_v498_n2-3_p179_Cramer_oai
institution Universidad de Buenos Aires
institution_str I-28
repository_str R-145
collection Repositorio Digital de la Universidad de Buenos Aires (UBA)
topic Carboxy-terminal domain
Coupling
mRNA processing
RNA polymerase II
messenger RNA
RNA polymerase II
capping phenomenon
carboxy terminal sequence
cell nucleus
nonhuman
phosphorylation
polyadenylation
priority journal
promoter region
RNA processing
RNA splicing
RNA transcription
short survey
spliceosome
transcription regulation
Humans
Macromolecular Substances
Models, Biological
RNA Polymerase II
RNA Precursors
RNA Processing, Post-Transcriptional
RNA Splicing
Transcription, Genetic
spellingShingle Carboxy-terminal domain
Coupling
mRNA processing
RNA polymerase II
messenger RNA
RNA polymerase II
capping phenomenon
carboxy terminal sequence
cell nucleus
nonhuman
phosphorylation
polyadenylation
priority journal
promoter region
RNA processing
RNA splicing
RNA transcription
short survey
spliceosome
transcription regulation
Humans
Macromolecular Substances
Models, Biological
RNA Polymerase II
RNA Precursors
RNA Processing, Post-Transcriptional
RNA Splicing
Transcription, Genetic
Cramer, P.
Srebrow, A.
Kadener, S.
Werbajh, S.
De La Mata, M.
Melen, G.
Nogués, G.
Kornblihtt, A.R.
Coordination between transcription and pre-mRNA processing
topic_facet Carboxy-terminal domain
Coupling
mRNA processing
RNA polymerase II
messenger RNA
RNA polymerase II
capping phenomenon
carboxy terminal sequence
cell nucleus
nonhuman
phosphorylation
polyadenylation
priority journal
promoter region
RNA processing
RNA splicing
RNA transcription
short survey
spliceosome
transcription regulation
Humans
Macromolecular Substances
Models, Biological
RNA Polymerase II
RNA Precursors
RNA Processing, Post-Transcriptional
RNA Splicing
Transcription, Genetic
description A large body of work has proved that transcription by RNA polymerase II and pre-mRNA processing are coordinated events within the cell nucleus. Capping, splicing and polyadenylation occur while transcription proceeds, suggesting that RNA polymerase II plays a role in the regulation of these events. The presence and degree of phosphorylation of the carboxy-terminal domain of RNA polymerase II large subunit is important for functioning of the capping enzymes, the assembly of spliceosomes and the binding of the cleavage/polyadenylation complex. Nuclear architecture and gene promoter structure have also been shown to play key roles in coupling between transcription and splicing. © 2001 Published by Elsevier Science B.V. on behalf of the Federation of European Biochemical Societies.
format Artículo
Artículo
publishedVersion
author Cramer, P.
Srebrow, A.
Kadener, S.
Werbajh, S.
De La Mata, M.
Melen, G.
Nogués, G.
Kornblihtt, A.R.
author_facet Cramer, P.
Srebrow, A.
Kadener, S.
Werbajh, S.
De La Mata, M.
Melen, G.
Nogués, G.
Kornblihtt, A.R.
author_sort Cramer, P.
title Coordination between transcription and pre-mRNA processing
title_short Coordination between transcription and pre-mRNA processing
title_full Coordination between transcription and pre-mRNA processing
title_fullStr Coordination between transcription and pre-mRNA processing
title_full_unstemmed Coordination between transcription and pre-mRNA processing
title_sort coordination between transcription and pre-mrna processing
publishDate 2001
url http://hdl.handle.net/20.500.12110/paper_00145793_v498_n2-3_p179_Cramer
http://repositoriouba.sisbi.uba.ar/gsdl/cgi-bin/library.cgi?a=d&c=artiaex&d=paper_00145793_v498_n2-3_p179_Cramer_oai
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AT delamatam coordinationbetweentranscriptionandpremrnaprocessing
AT meleng coordinationbetweentranscriptionandpremrnaprocessing
AT noguesg coordinationbetweentranscriptionandpremrnaprocessing
AT kornblihttar coordinationbetweentranscriptionandpremrnaprocessing
_version_ 1766026527957319680

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