Acción del plaguicida organofosforado clorpirifos sobre la carcinogénesis mamaria
In the last years, environmental pollutants have become an issue of serious\nconcern in relation to human health problems. Breast cancer risk has been related to\npollutants exposure because of many toxicants may act as endocrine disruptor by\naffecting the normal physiology of the mammary gland. In...
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Formato: | Tesis doctoral acceptedVersion |
Lenguaje: | Español |
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Facultad de Farmacia y Bioquímica
2014
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Acceso en línea: | http://repositoriouba.sisbi.uba.ar/gsdl/cgi-bin/library.cgi?a=d&c=posgraafa&cl=CL1&d=HWA_822 http://repositoriouba.sisbi.uba.ar/gsdl/collect/posgraafa/index/assoc/HWA_822.dir/822.PDF |
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I28-R145-HWA_8222019-09-25 In the last years, environmental pollutants have become an issue of serious\nconcern in relation to human health problems. Breast cancer risk has been related to\npollutants exposure because of many toxicants may act as endocrine disruptor by\naffecting the normal physiology of the mammary gland. In our work, we have\ndemonstrated that low doses of the organophosphorus pesticide chlorpyrifos (CPF)\ninduce MCF-7 breast cancer cells proliferation mediated by estrogen receptor action.\nHigher doses of the pesticide conduce to a diminished clonogenicity through an\nincrement of reactive oxygen species (ROS) and ERK1/2 phosphorylation. Therefore,\nCPF modified mammary gland structure in rats, induced the appearance of benign\nlesions as adenosis or florid ductal hyperplasia. CPF also affected the endocrine system\nby changing steroid and pituitary hormone levels and steroidogenesis. Finally, we have\nfound that CPF predisposes to breast cancer promotion in an experimental model in rats.\nOur results provide new findings on the mechanism of action induced by the\norganophosphorus CPF in breast cancer cells where the pesticide interferes in redox\nbalance, activates MAPKs pathways, affects the endocrine system and mammary gland\nhistology structure. Altogether, our results point to CPF as a new factor risk for breast\ncancer. Fil: Ventura, Clara. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina Nuñez, Mariel Facultad de Farmacia y Bioquímica Cocca, Claudia M. Ventura, Clara 2014-12-18 En los últimos años, ha cobrado importancia el estudio de los contaminantes\nambientales en relación al desarrollo de cáncer, en especial para el cáncer de mama,\ndebido a que muchos de los plaguicidas de uso corriente pueden actuar como\ndisruptores endócrinos (DEs), afectando la fisiología de la glándula mamaria.\nEn este trabajo, demostramos que bajas concentraciones del plaguicida\norganofosforado clorpirifos (CPF) inducen la proliferación de la línea celular MCF-7 en\nforma dependiente del RE?, mientras que, concentraciones mayores, conducen a una\ndisminución de la capacidad clonogénica celular mediada por un incremento en los\nniveles de ERO y la fosforilación de la proteína ERK1/2.\nAsimismo, el CPF modificó la histología de la glándula mamaria de rata\nconduciendo a la aparición de lesiones proliferativas como la adenosis y la hiperplasia\nductal, afectó el sistema endócrino modificando los niveles circulantes de las hormonas\nesteroideas e hipofisarias y alterando la esteroidogénesis ovárica. Finalmente, evidenciamos un efecto estimulante del CPF sobre la carcinogénesis mamaria mediante estudios en un modelo experimental en rata.\nNuestros resultados aportan nueva información acerca de los mecanismos de\nacción del plaguicida CPF en las células mamarias. Además de interferir con el\nmetabolismo redox, el CPF regula la activación de diferentes vías de señalización,\ndesregula el sistema endócrino, modifica la histología del tejido mamario y afecta la\ncarcinogénesis en este tejido. application/pdf Álvarez, Élida Rodríguez, Horacio Loaiza Pérez, Andrea Clorpirifos Disruptor endócrino Estrés oxidativo spa Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-nd/2.5/ar/ Ciencia de la vida Acción del plaguicida organofosforado clorpirifos sobre la carcinogénesis mamaria info:eu-repo/semantics/doctoralThesis info:ar-repo/semantics/tesis doctoral info:eu-repo/semantics/acceptedVersion http://repositoriouba.sisbi.uba.ar/gsdl/cgi-bin/library.cgi?a=d&c=posgraafa&cl=CL1&d=HWA_822 http://repositoriouba.sisbi.uba.ar/gsdl/collect/posgraafa/index/assoc/HWA_822.dir/822.PDF |
institution |
Universidad de Buenos Aires |
institution_str |
I-28 |
repository_str |
R-145 |
collection |
Repositorio Digital de la Universidad de Buenos Aires (UBA) |
language |
Español |
orig_language_str_mv |
spa |
topic |
Clorpirifos Disruptor endócrino Estrés oxidativo Ciencia de la vida |
spellingShingle |
Clorpirifos Disruptor endócrino Estrés oxidativo Ciencia de la vida Ventura, Clara Acción del plaguicida organofosforado clorpirifos sobre la carcinogénesis mamaria |
topic_facet |
Clorpirifos Disruptor endócrino Estrés oxidativo Ciencia de la vida |
description |
In the last years, environmental pollutants have become an issue of serious\nconcern in relation to human health problems. Breast cancer risk has been related to\npollutants exposure because of many toxicants may act as endocrine disruptor by\naffecting the normal physiology of the mammary gland. In our work, we have\ndemonstrated that low doses of the organophosphorus pesticide chlorpyrifos (CPF)\ninduce MCF-7 breast cancer cells proliferation mediated by estrogen receptor action.\nHigher doses of the pesticide conduce to a diminished clonogenicity through an\nincrement of reactive oxygen species (ROS) and ERK1/2 phosphorylation. Therefore,\nCPF modified mammary gland structure in rats, induced the appearance of benign\nlesions as adenosis or florid ductal hyperplasia. CPF also affected the endocrine system\nby changing steroid and pituitary hormone levels and steroidogenesis. Finally, we have\nfound that CPF predisposes to breast cancer promotion in an experimental model in rats.\nOur results provide new findings on the mechanism of action induced by the\norganophosphorus CPF in breast cancer cells where the pesticide interferes in redox\nbalance, activates MAPKs pathways, affects the endocrine system and mammary gland\nhistology structure. Altogether, our results point to CPF as a new factor risk for breast\ncancer. |
author2 |
Nuñez, Mariel |
author_facet |
Nuñez, Mariel Ventura, Clara |
format |
Tesis doctoral Tesis doctoral acceptedVersion |
author |
Ventura, Clara |
author_sort |
Ventura, Clara |
title |
Acción del plaguicida organofosforado clorpirifos sobre la carcinogénesis mamaria |
title_short |
Acción del plaguicida organofosforado clorpirifos sobre la carcinogénesis mamaria |
title_full |
Acción del plaguicida organofosforado clorpirifos sobre la carcinogénesis mamaria |
title_fullStr |
Acción del plaguicida organofosforado clorpirifos sobre la carcinogénesis mamaria |
title_full_unstemmed |
Acción del plaguicida organofosforado clorpirifos sobre la carcinogénesis mamaria |
title_sort |
acción del plaguicida organofosforado clorpirifos sobre la carcinogénesis mamaria |
publisher |
Facultad de Farmacia y Bioquímica |
publishDate |
2014 |
url |
http://repositoriouba.sisbi.uba.ar/gsdl/cgi-bin/library.cgi?a=d&c=posgraafa&cl=CL1&d=HWA_822 http://repositoriouba.sisbi.uba.ar/gsdl/collect/posgraafa/index/assoc/HWA_822.dir/822.PDF |
work_keys_str_mv |
AT venturaclara acciondelplaguicidaorganofosforadoclorpirifossobrelacarcinogenesismamaria |
_version_ |
1766017574453116928 |