Estado inflamatorio, oxidante y proaterogénico en trastornos del metabolismo del hierro
Iron overload and deficiency were associated with increased risk of cardiovascular disease (CVD). However, the mechanisms involved and the clinical impact of such alterations are scarcely known. Moreover, the therapeutic potential of maintaining iron homeostasis over CVD risk factors has not been fu...
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| Formato: | Tesis doctoral acceptedVersion |
| Lenguaje: | Español |
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Facultad de Farmacia y Bioquímica
2015
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| Acceso en línea: | http://repositoriouba.sisbi.uba.ar/gsdl/cgi-bin/library.cgi?a=d&c=posgraafa&cl=CL1&d=HWA_795 http://repositoriouba.sisbi.uba.ar/gsdl/collect/posgraafa/index/assoc/HWA_795.dir/795.PDF |
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I28-R145-HWA_7952019-09-25 Iron overload and deficiency were associated with increased risk of cardiovascular disease (CVD). However, the mechanisms involved and the clinical impact of such alterations are scarcely known. Moreover, the therapeutic potential of maintaining iron homeostasis over CVD risk factors has not been fully studied. The aim of this thesis was to evaluate the role of iron levels over biomarkers of inflammation, endothelial dysfunction and atherosclerosis in patients with iron overload and deficiency in comparison with healthy controls, and to assess the impact of their respective treatments. Indicators of glucose and lipoprotein metabolism, the activities of lipoprotein-associated enzymes, the chemical composition and functionality of isolated lipoproteins and biomarkers of inflammation and atherosclerosis were evaluated. Patients with iron metabolism alterations showed a proatherogenic lipoprotein profile with presence of modified and dysfunctional lipoproteins and a proinflammatory state with increased lipoprotein-associated phospholipase A2. Such alterations were corrected in response to the treatments of each condition. In conclusion, iron overload and deficiency are associated with metabolic alterations and a proinflammatory state which might enhance the development of atherosclerotic CVD. Fil: Meroño, Tomás. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento Bioquímica Clínica. Instituto de Fisiopatología y Bioquímica Clínica; Argentina Facultad de Farmacia y Bioquímica Brites, Fernando Daniel Meroño, Tomás 2015-03-17 La sobrecarga y la deficiencia de hierro fueron asociadas a mayor riesgo de enfermedad cardiovascular (ECV). Sin embargo, los mecanismos involucrados y su impacto clínico resultan poco conocidos. Asimismo, aún no ha sido evaluado el potencial terapéutico del mantenimiento de la homeostasis del hierro sobre los factores de riesgo de ECV. El objetivo de la tesis fue evaluar el rol de los niveles de hierro sobre la inflamación, la disfunción endotelial y la aterosclerosis a través del estudio de sus bioindicadores en pacientes con sobrecarga y deficiencia de hierro en comparación con controles sanos, y estudiar el impacto de sus respectivos tratamientos. Se evaluó el metabolismo de los glúcidos y los lípidos, la actividad de enzimas asociadas a lipoproteínas, la composición química y funcionalidad de las lipoproteínas aisladas, y bioindicadores de inflamación y aterosclerosis. En ambos trastornos del metabolismo del hierro, se observaron: alteraciones en el perfil lipoproteico, presencia de lipoproteínas modificadas y disfuncionales, y un estado proinflamatorio caracterizado por una mayor actividad de fosfolipasa-A2 asociada a lipoproteínas. Estas alteraciones revirtieron en respuesta a los tratamientos respectivos de cada condición. En conclusión, las alteraciones del metabolismo del hierro se asocian a procesos proinflamatorios capaces de promover el desarrollo de ECV. application/pdf Slobodianik, Nora Feliu, María Garda, Horacio Metabolismos del hierro Estado inflamatorio Proaterogénico spa Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by-nc-nd/2.5/ar/ Ciencia de la vida Estado inflamatorio, oxidante y proaterogénico en trastornos del metabolismo del hierro info:eu-repo/semantics/doctoralThesis info:ar-repo/semantics/tesis doctoral info:eu-repo/semantics/acceptedVersion http://repositoriouba.sisbi.uba.ar/gsdl/cgi-bin/library.cgi?a=d&c=posgraafa&cl=CL1&d=HWA_795 http://repositoriouba.sisbi.uba.ar/gsdl/collect/posgraafa/index/assoc/HWA_795.dir/795.PDF |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-145 |
| collection |
Repositorio Digital de la Universidad de Buenos Aires (UBA) |
| language |
Español |
| orig_language_str_mv |
spa |
| topic |
Metabolismos del hierro Estado inflamatorio Proaterogénico Ciencia de la vida |
| spellingShingle |
Metabolismos del hierro Estado inflamatorio Proaterogénico Ciencia de la vida Meroño, Tomás Estado inflamatorio, oxidante y proaterogénico en trastornos del metabolismo del hierro |
| topic_facet |
Metabolismos del hierro Estado inflamatorio Proaterogénico Ciencia de la vida |
| description |
Iron overload and deficiency were associated with increased risk of cardiovascular disease (CVD). However, the mechanisms involved and the clinical impact of such alterations are scarcely known. Moreover, the therapeutic potential of maintaining iron homeostasis over CVD risk factors has not been fully studied. The aim of this thesis was to evaluate the role of iron levels over biomarkers of inflammation, endothelial dysfunction and atherosclerosis in patients with iron overload and deficiency in comparison with healthy controls, and to assess the impact of their respective treatments. Indicators of glucose and lipoprotein metabolism, the activities of lipoprotein-associated enzymes, the chemical composition and functionality of isolated lipoproteins and biomarkers of inflammation and atherosclerosis were evaluated. Patients with iron metabolism alterations showed a proatherogenic lipoprotein profile with presence of modified and dysfunctional lipoproteins and a proinflammatory state with increased lipoprotein-associated phospholipase A2. Such alterations were corrected in response to the treatments of each condition. In conclusion, iron overload and deficiency are associated with metabolic alterations and a proinflammatory state which might enhance the development of atherosclerotic CVD. |
| author2 |
Brites, Fernando Daniel |
| author_facet |
Brites, Fernando Daniel Meroño, Tomás |
| format |
Tesis doctoral Tesis doctoral acceptedVersion |
| author |
Meroño, Tomás |
| author_sort |
Meroño, Tomás |
| title |
Estado inflamatorio, oxidante y proaterogénico en trastornos del metabolismo del hierro |
| title_short |
Estado inflamatorio, oxidante y proaterogénico en trastornos del metabolismo del hierro |
| title_full |
Estado inflamatorio, oxidante y proaterogénico en trastornos del metabolismo del hierro |
| title_fullStr |
Estado inflamatorio, oxidante y proaterogénico en trastornos del metabolismo del hierro |
| title_full_unstemmed |
Estado inflamatorio, oxidante y proaterogénico en trastornos del metabolismo del hierro |
| title_sort |
estado inflamatorio, oxidante y proaterogénico en trastornos del metabolismo del hierro |
| publisher |
Facultad de Farmacia y Bioquímica |
| publishDate |
2015 |
| url |
http://repositoriouba.sisbi.uba.ar/gsdl/cgi-bin/library.cgi?a=d&c=posgraafa&cl=CL1&d=HWA_795 http://repositoriouba.sisbi.uba.ar/gsdl/collect/posgraafa/index/assoc/HWA_795.dir/795.PDF |
| work_keys_str_mv |
AT meronotomas estadoinflamatoriooxidanteyproaterogenicoentrastornosdelmetabolismodelhierro |
| _version_ |
1766017570997010432 |