InVet 2021, 23 (1): 01-15 REVISIÓN BIBLIOGRÁFICA ISSN...
Melanin pigment and melanoma are two fields of increasing interest and relevance in biomedical research. Melanins are ubiquitous biopigments with strong adaptive value and multiple functions. In mammals, melanin corresponds to eumelanin (brown-black) and pheomelanin (yellow-red), and is found mainly...
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| Formato: | Artículo publishedVersion |
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Universidad de Buenos Aires. Facultad de Ciencias Veterinarias
2021
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| Acceso en línea: | http://repositoriouba.sisbi.uba.ar/gsdl/cgi-bin/library.cgi?a=d&c=pveterinaria/invet&cl=CL1&d=HWA_6757 https://repositoriouba.sisbi.uba.ar/gsdl/collect/pveterinaria/invet/index/assoc/HWA_6757.dir/6757.PDF |
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I28-R145-HWA_6757 |
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dspace |
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Universidad de Buenos Aires |
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I-28 |
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R-145 |
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Repositorio Digital de la Universidad de Buenos Aires (UBA) |
| language |
Inglés |
| orig_language_str_mv |
eng |
| topic |
eumelanina fototerapia melanoma polímeros de indol terapia antitumoral antitumor therapy eumelanin indole polymers melanoma photothermal therapy |
| spellingShingle |
eumelanina fototerapia melanoma polímeros de indol terapia antitumoral antitumor therapy eumelanin indole polymers melanoma photothermal therapy Stockert, J.C. InVet 2021, 23 (1): 01-15 REVISIÓN BIBLIOGRÁFICA ISSN... |
| topic_facet |
eumelanina fototerapia melanoma polímeros de indol terapia antitumoral antitumor therapy eumelanin indole polymers melanoma photothermal therapy |
| description |
Melanin pigment and melanoma are two fields of increasing interest and relevance in biomedical research. Melanins are ubiquitous biopigments with strong adaptive value and multiple functions. In mammals, melanin corresponds to eumelanin (brown-black) and pheomelanin (yellow-red), and is found mainly in the skin and derivatives, retinal pigmented epithelium, and central nervous systems (neuromelanin, in substantia nigra, locus coeruleus, etc.). Melanin also occurs in the malignant melanoma, which is one of the most aggressive and therapy-resistant tumors in veterinary and human medicine. Several chemical structures have been proposed for eumelanin, but there is still no agreement about its molecular organization. Two models, namely a flexible linear chain, and a rigid planar chain, are the structures that better agree with physico-chemical properties of eumelanin. The latter model, which appears as the most plausible structure, corresponds to a benzoquinone derivative of the porphycene ring, and explains the broad-band light absorption, antioxidant capacity, electric conductivity, and photothermal effect, as well as the multilayered and graphite-like organization shown by X-ray crystallography and electron microscopy. In addition to traditional oncologic treatments and recent immunological and gene therapy advances, photodynamic and photothermal approaches represent novel therapeutic modalities for melanoma. In the latter case, since eumelanin is practically the ideal photothermal sensitizer, the massive vibrational decay from photo-excited electronic states after NIR irradiation induces an immediate and highly efficient heating response that results in coagulative necrosis of the tumor. This allows repetitive treatments due to the remaining melanin contained in tumoral melanophages. Although the evolution and prognosis of the advanced melanoma is still a concern, new physical procedures can now be applied. |
| format |
Artículo Artículo publishedVersion |
| author |
Stockert, J.C. |
| author_facet |
Stockert, J.C. |
| author_sort |
Stockert, J.C. |
| title |
InVet 2021, 23 (1): 01-15 REVISIÓN BIBLIOGRÁFICA ISSN... |
| title_short |
InVet 2021, 23 (1): 01-15 REVISIÓN BIBLIOGRÁFICA ISSN... |
| title_full |
InVet 2021, 23 (1): 01-15 REVISIÓN BIBLIOGRÁFICA ISSN... |
| title_fullStr |
InVet 2021, 23 (1): 01-15 REVISIÓN BIBLIOGRÁFICA ISSN... |
| title_full_unstemmed |
InVet 2021, 23 (1): 01-15 REVISIÓN BIBLIOGRÁFICA ISSN... |
| title_sort |
invet 2021, 23 (1): 01-15 revisión bibliográfica issn... |
| publisher |
Universidad de Buenos Aires. Facultad de Ciencias Veterinarias |
| publishDate |
2021 |
| url |
http://repositoriouba.sisbi.uba.ar/gsdl/cgi-bin/library.cgi?a=d&c=pveterinaria/invet&cl=CL1&d=HWA_6757 https://repositoriouba.sisbi.uba.ar/gsdl/collect/pveterinaria/invet/index/assoc/HWA_6757.dir/6757.PDF |
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1824359738389823488 |
| spelling |
I28-R145-HWA_67572024-11-05 InVet 2021, 23 (1): 01-15 REVISIÓN BIBLIOGRÁFICA ISSN... Melanin pigment and melanoma are two fields of increasing interest and relevance in biomedical research. Melanins are ubiquitous biopigments with strong adaptive value and multiple functions. In mammals, melanin corresponds to eumelanin (brown-black) and pheomelanin (yellow-red), and is found mainly in the skin and derivatives, retinal pigmented epithelium, and central nervous systems (neuromelanin, in substantia nigra, locus coeruleus, etc.). Melanin also occurs in the malignant melanoma, which is one of the most aggressive and therapy-resistant tumors in veterinary and human medicine. Several chemical structures have been proposed for eumelanin, but there is still no agreement about its molecular organization. Two models, namely a flexible linear chain, and a rigid planar chain, are the structures that better agree with physico-chemical properties of eumelanin. The latter model, which appears as the most plausible structure, corresponds to a benzoquinone derivative of the porphycene ring, and explains the broad-band light absorption, antioxidant capacity, electric conductivity, and photothermal effect, as well as the multilayered and graphite-like organization shown by X-ray crystallography and electron microscopy. In addition to traditional oncologic treatments and recent immunological and gene therapy advances, photodynamic and photothermal approaches represent novel therapeutic modalities for melanoma. In the latter case, since eumelanin is practically the ideal photothermal sensitizer, the massive vibrational decay from photo-excited electronic states after NIR irradiation induces an immediate and highly efficient heating response that results in coagulative necrosis of the tumor. This allows repetitive treatments due to the remaining melanin contained in tumoral melanophages. Although the evolution and prognosis of the advanced melanoma is still a concern, new physical procedures can now be applied. Fil: Stockert, J.C. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias. Instituto de Investigación y Tecnología en Reproducción Animal (INITRA). Buenos Aires, Argentina Fil: Stockert, J.C. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Oncología "Angel H. Roffo". Area Investigación. Buenos Aires, Argentina Stockert, J.C. 2021 La melanina y el melanoma son dos campos de interés y relevancia crecientes en investigación biomédica. Las melaninas son biopigmentos ubicuos con gran valor adaptativo y múltiples funciones. En mamíferos, la melanina corresponde a la eumelanina (marron-negro) y a la feomelanina (amarillo-rojo), y se encuentra en la piel y derivados, epitelio pigmentado de la retina, y sistema nervioso central (neuromelanina, en substantia nigra, locus coeruleus, etc). La melanina también está presente en el melanoma maligno, uno de los tumores más agresivos y resistentes a la terapia en medicina veterinaria y humana. Varias estructuras químicas han sido propuestas para la eumelanina, pero todavía no hay acuerdo sobre su organización molecular. Dos modelos, uno constituido por una cadena linear y flexible, y otro por una cadena plana y rígida son las estructuras que mejor encajan con las propiedades físico-químicas de la eumelanina. El último modelo, que parece ser la estructura más plausible, corresponde a un derivado benzoquinónico del porficeno y explica la absorción de luz de banda ancha, la capacidad antioxidante, la conductividad eléctrica y el efecto fototérmico, así como también la organización en multicapa similar al grafito mostrada por la cristalografía de rayos X y la microscopía electrónica. Sumados a los tratamientos oncológicos tradicionales y a los avances inmunológicos y de terapia génica más recientes, los abordajes fotodinámico y fototérmico representan novedosas modalidades terapéuticas para el melanoma. En este último caso, como la eumelanina es el sensibilizador fototérmico prácticamente ideal, el decaimiento vibracional masivo a partir de estados electrónicos foto-excitados por NIR induce un calentamiento inmediato y muy eficiente que produce la necrosis coagulativa del tumor. Esta respuesta permite tratamientos repetidos debido a la melanina remanente contenida en los melanófagos tumorales. Aunque la evolución y pronóstico del melanoma avanzado son todavía asuntos preocupantes, nuevos procedimientos físicos pueden ser ahora aplicados. application/pdf ISSN 1668-3498 (en línea) eumelanina fototerapia melanoma polímeros de indol terapia antitumoral antitumor therapy eumelanin indole polymers melanoma photothermal therapy eng Universidad de Buenos Aires. Facultad de Ciencias Veterinarias info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-nd/2.5/ar/ InVet, vol. 23, nº1 Melanin and melanoma: Updating molecular structure and photothermal therapy Melanina y melanoma: Actualización de la estructura molecular y terapia fototérmica info:eu-repo/semantics/article info:ar-repo/semantics/artículo info:eu-repo/semantics/publishedVersion http://repositoriouba.sisbi.uba.ar/gsdl/cgi-bin/library.cgi?a=d&c=pveterinaria/invet&cl=CL1&d=HWA_6757 https://repositoriouba.sisbi.uba.ar/gsdl/collect/pveterinaria/invet/index/assoc/HWA_6757.dir/6757.PDF |