Marcadores moleculares de la progresión tumoral asociados a cadherina epitelial en cáncer de próstata y vejiga

Epithelial Cadherin (ECad) is a transmembrane glycoprotein that plays a main role in cell-cell adhesion. Ecad loss is a key event on Epithelial to Mesenchymal Transition (EMT), a process by which epithelial cells dramatic change in their molecular expression profile and acquire a motile and invasive...

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Autor principal: Mencucci, María Victoria
Otros Autores: Vaccaro, María Inés
Formato: Tesis doctoral acceptedVersion
Lenguaje:Español
Publicado: Facultad de Farmacia y Bioquímica 2017
Materias:
Cáncer de próstata
Vejiga
Cadherina epitelial
Ciencias de la vida
Acceso en línea:http://repositoriouba.sisbi.uba.ar/gsdl/cgi-bin/library.cgi?a=d&c=posgraafa&cl=CL1&d=HWA_5757
http://repositoriouba.sisbi.uba.ar/gsdl/collect/posgraafa/index/assoc/HWA_5757.dir/5757.PDF
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Repositorio Digital de la Universidad de Buenos Aires (UBA) de Universidad de Buenos Aires
id I28-R145-HWA_5757
record_format dspace
spelling I28-R145-HWA_57572022-04-06 Epithelial Cadherin (ECad) is a transmembrane glycoprotein that plays a main role in cell-cell adhesion. Ecad loss is a key event on Epithelial to Mesenchymal Transition (EMT), a process by which epithelial cells dramatic change in their molecular expression profile and acquire a motile and invasive behavior. These events lead to local invasion and distant metastasis, characteristics of tumor progression and aggressiveness.\nAn abnormal expression/function of ECad and other EMT-related molecules have been reported in Prostate Cancer (PC) and Bladder Cancer (BC) tumor progression, but studies are not conclusive. Moreover, there are molecules related to ECad and tumor aggressiveness that have not been studied in these tumors. Specifically, Dysadherin (Dys) has been found over-expressed in several solid tumors and associated with metastasis, but no studies have reported its expression in PC. Moreover, Ephrin-B1 has been related to ?-catenin deregulation and cell aggressiveness in other tumors, but no studies have reported its expression and function in BC.\nThe present study has thoroughly characterized the expression of ECad and other EMT-related molecules in PC and BC. Moreover, it is the first reporting expression of Dys in PC and Ephrin-B1 in BC, and their association with tumor progression and aggressiveness in these tumors. Fil: Mencucci, María Victoria. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Buenos Aires, Argentina Vaccaro, María Inés Facultad de Farmacia y Bioquímica Vazquez-Levin, Mónica Mencucci, María Victoria 2017-07-25 Cadherina Epitelial (CadE) es una glicoproteína transmembrana que cumple un rol fundamental en la adhesión intercelular. La pérdida de CadE es clave en la Transición Epitelio Mensenquimal (TEM); las células pierden capacidad adhesiva y ganan comportamientomótil e invasivo, posibilitando la progresión tumoral a través de la invasión local de los tejidos y la metástasis a distancia.\nEn el Cáncer de Próstata (CP) y el Cáncer de Vejiga (CV) se han reportado alteraciones en la expresión/función(es) de CadE y de otras moléculas relacionadas a la TEM, pero los estudios no son concluyentes. Asimismo, existen moléculas relacionadas a CadE y a la progresión y agresividad tumoral que aún no han sido estudiadas en estos tumores. Específicamente, Disadherina (Dys) se ha encontrado sobreexpresada en numerosos tumores sólidos y asociada a la metástasis, no habiendo antecedentes en CP. Asimismo, Efrina-B1 ha sido relacionada a la desregulación de ?-catenina y la agresividad tumoral, pero no hay antecedentes de su expresión en CV.\nEl presente estudio ha caracterizado la expresión de CadE y otros marcadores de la TEM en CP y CV. Asimismo, por primera vez describe la expresión de Dys en CP y Efrina-B1 en CV y las asocia a la progresión y agresividad tumoral de estos tumores. application/pdf Medina, Vanina Juvenal, Guillermo Vázquez, Elba Cáncer de próstata Vejiga Cadherina epitelial spa Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by-nc-nd/2.5/ar/ Ciencias de la vida Marcadores moleculares de la progresión tumoral asociados a cadherina epitelial en cáncer de próstata y vejiga info:eu-repo/semantics/doctoralThesis info:ar-repo/semantics/tesis doctoral info:eu-repo/semantics/acceptedVersion http://repositoriouba.sisbi.uba.ar/gsdl/cgi-bin/library.cgi?a=d&c=posgraafa&cl=CL1&d=HWA_5757 http://repositoriouba.sisbi.uba.ar/gsdl/collect/posgraafa/index/assoc/HWA_5757.dir/5757.PDF
institution Universidad de Buenos Aires
institution_str I-28
repository_str R-145
collection Repositorio Digital de la Universidad de Buenos Aires (UBA)
language Español
orig_language_str_mv spa
topic Cáncer de próstata
Vejiga
Cadherina epitelial
Ciencias de la vida
spellingShingle Cáncer de próstata
Vejiga
Cadherina epitelial
Ciencias de la vida
Mencucci, María Victoria
Marcadores moleculares de la progresión tumoral asociados a cadherina epitelial en cáncer de próstata y vejiga
topic_facet Cáncer de próstata
Vejiga
Cadherina epitelial
Ciencias de la vida
description Epithelial Cadherin (ECad) is a transmembrane glycoprotein that plays a main role in cell-cell adhesion. Ecad loss is a key event on Epithelial to Mesenchymal Transition (EMT), a process by which epithelial cells dramatic change in their molecular expression profile and acquire a motile and invasive behavior. These events lead to local invasion and distant metastasis, characteristics of tumor progression and aggressiveness.\nAn abnormal expression/function of ECad and other EMT-related molecules have been reported in Prostate Cancer (PC) and Bladder Cancer (BC) tumor progression, but studies are not conclusive. Moreover, there are molecules related to ECad and tumor aggressiveness that have not been studied in these tumors. Specifically, Dysadherin (Dys) has been found over-expressed in several solid tumors and associated with metastasis, but no studies have reported its expression in PC. Moreover, Ephrin-B1 has been related to ?-catenin deregulation and cell aggressiveness in other tumors, but no studies have reported its expression and function in BC.\nThe present study has thoroughly characterized the expression of ECad and other EMT-related molecules in PC and BC. Moreover, it is the first reporting expression of Dys in PC and Ephrin-B1 in BC, and their association with tumor progression and aggressiveness in these tumors.
author2 Vaccaro, María Inés
author_facet Vaccaro, María Inés
Mencucci, María Victoria
format Tesis doctoral
Tesis doctoral
acceptedVersion
author Mencucci, María Victoria
author_sort Mencucci, María Victoria
title Marcadores moleculares de la progresión tumoral asociados a cadherina epitelial en cáncer de próstata y vejiga
title_short Marcadores moleculares de la progresión tumoral asociados a cadherina epitelial en cáncer de próstata y vejiga
title_full Marcadores moleculares de la progresión tumoral asociados a cadherina epitelial en cáncer de próstata y vejiga
title_fullStr Marcadores moleculares de la progresión tumoral asociados a cadherina epitelial en cáncer de próstata y vejiga
title_full_unstemmed Marcadores moleculares de la progresión tumoral asociados a cadherina epitelial en cáncer de próstata y vejiga
title_sort marcadores moleculares de la progresión tumoral asociados a cadherina epitelial en cáncer de próstata y vejiga
publisher Facultad de Farmacia y Bioquímica
publishDate 2017
url http://repositoriouba.sisbi.uba.ar/gsdl/cgi-bin/library.cgi?a=d&c=posgraafa&cl=CL1&d=HWA_5757
http://repositoriouba.sisbi.uba.ar/gsdl/collect/posgraafa/index/assoc/HWA_5757.dir/5757.PDF
work_keys_str_mv AT mencuccimariavictoria marcadoresmolecularesdelaprogresiontumoralasociadosacadherinaepitelialencancerdeprostatayvejiga
_version_ 1766017547767906304

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