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Hip dysplasia (HD) is a polygenic disease characterized by joint laxity and lack of congruence leading to osteoarthritis (OA). Under many pathogenic conditions including arthritis, MMP-1 synthesis is augmented. The MMP-1 gene promoter contains cytokine response elements, transcription factors AP-1 a...

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Autores principales: Fassa, V.B., Oertlin, G., Waldhorn, J.G., Álvarez, A.O., Maubecin, E.G., Pazos, D.A., Flores, M., Pinto, G.B., Huguet, M.J., Conte, A., Marrube, G.
Formato: Artículo publishedVersion
Lenguaje:Inglés
Publicado: Universidad de Buenos Aires. Facultad de Ciencias Veterinarias. 2010
Materias:
canis lupus familiaris
displasia de cadera
osteoartritis
gen MMP-1
polimorfismos
hip dysplasia
osteoarthritis
MMP-1 gene
polymorphisms
Acceso en línea:http://repositoriouba.sisbi.uba.ar/gsdl/cgi-bin/library.cgi?a=d&c=pveterinaria/invet&cl=CL1&d=HWA_4996
https://repositoriouba.sisbi.uba.ar/gsdl/collect/pveterinaria/invet/index/assoc/HWA_4996.dir/4996.PDF
Aporte de:
Repositorio Digital de la Universidad de Buenos Aires (UBA) de Universidad de Buenos Aires
Descripción
Sumario:Hip dysplasia (HD) is a polygenic disease characterized by joint laxity and lack of congruence leading to osteoarthritis (OA). Under many pathogenic conditions including arthritis, MMP-1 synthesis is augmented. The MMP-1 gene promoter contains cytokine response elements, transcription factors AP-1 and SAF-1 that are increased in OA. The objective of the present study was to identify and characterize new polymorphisms of the canine MMP-1 promoter gene and evaluate their association with OA secondary to HD in different dog breeds. Based on the NCBI_006587 reference sequence, two novel polymorphisms, Indel CTGCCCT (bp31986794) and C>T (bpSNP 31986815) substitution were selected due their position in a consensus sequence belonging to a SAF-1 response element. Data was uploaded in the GenBank database (accession number GQ475524 and GQ475525). 125 dogs of different breeds were sampled and hip status was evaluated through ventrodorsal extended-hip radiographs. A chi-squared analysis was performed to test the association of the variables: breed, sex and genotype for each polymorphism with OA status (healthy and affected). No significant association (p>0.05) was found between any variable and OA secondary to HD. This study does not exclude MMP-1 as a gene responsible of OA secondary to HD in the breeds sampled because only the promoter sequence was evaluated.\n

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