vagnozzi.pmd

Rinderpest Virus (RPV) is the causative agent of a serious disease of domestic cattle. RPV is an enveloped virus with a single stranded, non-segmented, negative RNA genome (-ssRNA), that is organized in six non-overlapping genes. P gene is the most complex of such genes. Its sequence codifies for a...

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Autores principales:	Vagnozzi, A., Carrillo, C.
Formato:	Artículo publishedVersion
Lenguaje:	Español
Publicado:	Universidad de Buenos Aires. Facultad de Ciencias Veterinarias. 2006
Acceso en línea:	http://repositoriouba.sisbi.uba.ar/gsdl/cgi-bin/library.cgi?a=d&c=pveterinaria/invet&cl=CL1&d=HWA_4677 https://repositoriouba.sisbi.uba.ar/gsdl/collect/pveterinaria/invet/index/assoc/HWA_4677.dir/4677.PDF
Aporte de:	Repositorio Digital de la Universidad de Buenos Aires (UBA) de Universidad de Buenos Aires

id	I28-R145-HWA_4677
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spelling	I28-R145-HWA_46772024-11-05 vagnozzi.pmd Rinderpest Virus (RPV) is the causative agent of a serious disease of domestic cattle. RPV is an enveloped virus with a single stranded, non-segmented, negative RNA genome (-ssRNA), that is organized in six non-overlapping genes. P gene is the most complex of such genes. Its sequence codifies for a structural (P) and two non-structural proteins (C and V). The P protein is essential for viral replication and is involved in every aspect of the viral cycle, whereas, C and V proteins are non essential for viral replication, at least in vitro. Here we have made a comparative analysis of sequences of the P gene and its codified proteins from 16 different isolations of RPV, focusing in conserved regions and its functional role. Rinderpest has been one of the most important threats to the cattle health. Actually, the disease is present just in some regions of Asia. The present comparative genomic analysis will be useful as epidemiological work and an important contribution to the current knowledge of RPV biology. Fil: Vagnozzi, A. United States Department of Agriculture. Agricultural Research Service. Plum Island Animal Disease Center. Foreign Animal Disease Research Unit. New York, United States of America Fil: Carrillo, C. United States Department of Agriculture. Agricultural Research Service. Plum Island Animal Disease Center. Foreign Animal Disease Research Unit. New York, United States of America Vagnozzi, A. Carrillo, C. 2006 Este trabajo mereció el premio Estímulo a la Investigación Científica, 2005, otorgado por la Facultad de Ciencias Veterinarias, UBA.\nRinderpest Virus (RPV) es el agente causal de una severa enfermedad del ganado doméstico. Es un virus envuelto, cuyo genoma RNA no segmentado, de cadena simple y negativa (-ssRNA), está organizado en seis genes no superpuestos. El gen P es el más complejo de dichos genes, codificando una proteína estructural (P) y dos no estructurales (C y V). La proteína P es esencial para la replicación viral y está involucrada en todos los aspectos del ciclo viral. En cambio, las proteínas C y V son consideradas no esenciales para la replicación, al menos in vitro. En este trabajo hemos secuenciado el gen P de 16 aislamientos diferentes de RPV, y realizado el análisis comparativo de las secuencias obtenidas, poniendo el énfasis en las regiones conservadas en relación a su importancia funcional. Rinderpest ha sido una de las amenazas mas importantes para la salud del ganado domestico. En la actualidad la enfermedad se presenta en ciertas regiones de Asia y está en vías de ser erradicada del planeta. La secuenciación y el análisis comparativo realizado en este trabajo es una herramienta sumamente útil y eficiente tanto para seguimiento epidemiológico del virus como para la evaluación de su biología. application/pdf 1514-6634 (impreso) 1668-3498 (en línea) spa Universidad de Buenos Aires. Facultad de Ciencias Veterinarias. info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-nd/2.5/ar/ InVet, vol. 08, nº1 Análisis comparativo del gen P de Rinderpest Virus (RPV) Comparative analysis of Rinderpest Virus (RPV) P gene info:eu-repo/semantics/article info:ar-repo/semantics/artículo info:eu-repo/semantics/publishedVersion http://repositoriouba.sisbi.uba.ar/gsdl/cgi-bin/library.cgi?a=d&c=pveterinaria/invet&cl=CL1&d=HWA_4677 https://repositoriouba.sisbi.uba.ar/gsdl/collect/pveterinaria/invet/index/assoc/HWA_4677.dir/4677.PDF
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-145
collection	Repositorio Digital de la Universidad de Buenos Aires (UBA)
language	Español
orig_language_str_mv	spa
description	Rinderpest Virus (RPV) is the causative agent of a serious disease of domestic cattle. RPV is an enveloped virus with a single stranded, non-segmented, negative RNA genome (-ssRNA), that is organized in six non-overlapping genes. P gene is the most complex of such genes. Its sequence codifies for a structural (P) and two non-structural proteins (C and V). The P protein is essential for viral replication and is involved in every aspect of the viral cycle, whereas, C and V proteins are non essential for viral replication, at least in vitro. Here we have made a comparative analysis of sequences of the P gene and its codified proteins from 16 different isolations of RPV, focusing in conserved regions and its functional role. Rinderpest has been one of the most important threats to the cattle health. Actually, the disease is present just in some regions of Asia. The present comparative genomic analysis will be useful as epidemiological work and an important contribution to the current knowledge of RPV biology.
format	Artículo Artículo publishedVersion
author	Vagnozzi, A. Carrillo, C.
spellingShingle	Vagnozzi, A. Carrillo, C. vagnozzi.pmd
author_facet	Vagnozzi, A. Carrillo, C.
author_sort	Vagnozzi, A.
title	vagnozzi.pmd
title_short	vagnozzi.pmd
title_full	vagnozzi.pmd
title_fullStr	vagnozzi.pmd
title_full_unstemmed	vagnozzi.pmd
title_sort	vagnozzi.pmd
publisher	Universidad de Buenos Aires. Facultad de Ciencias Veterinarias.
publishDate	2006
url	http://repositoriouba.sisbi.uba.ar/gsdl/cgi-bin/library.cgi?a=d&c=pveterinaria/invet&cl=CL1&d=HWA_4677 https://repositoriouba.sisbi.uba.ar/gsdl/collect/pveterinaria/invet/index/assoc/HWA_4677.dir/4677.PDF
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vagnozzi.pmd

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