InVet. 2018, 20 (1-2): 23-32 EXPERIMENTAL ISSN 1514-6634 (impreso) MODEL...
The purpose of this work was to present an experimental murine model as an alternative to the bovine one, to evaluate the efficacy of experimental vaccines against Tritrichomonas foetus. The vaccines employed consisted of inactivated protozoa with different formulations: (A) with oil adjuvant, (B) a...
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| Autores principales: | , , , , , |
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| Formato: | Artículo publishedVersion |
| Lenguaje: | Inglés |
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Universidad de Buenos Aires. Facultad de Ciencias Veterinarias.
2018
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| Acceso en línea: | http://repositoriouba.sisbi.uba.ar/gsdl/cgi-bin/library.cgi?a=d&c=pveterinaria/invet&cl=CL1&d=HWA_3615 https://repositoriouba.sisbi.uba.ar/gsdl/collect/pveterinaria/invet/index/assoc/HWA_3615.dir/3615.PDF |
| Aporte de: |
| id |
I28-R145-HWA_3615 |
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| record_format |
dspace |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-145 |
| collection |
Repositorio Digital de la Universidad de Buenos Aires (UBA) |
| language |
Inglés |
| orig_language_str_mv |
eng |
| topic |
Tritrichomonas foetus Modelo ratón Vacuna Tritrichomonas foetus Mouse model vaccine |
| spellingShingle |
Tritrichomonas foetus Modelo ratón Vacuna Tritrichomonas foetus Mouse model vaccine Soto, P. Echeverría, H.M. Doumecq, M.L. Cacciato, C.S. Rodriguez, E. Monteavaro, C.E. InVet. 2018, 20 (1-2): 23-32 EXPERIMENTAL ISSN 1514-6634 (impreso) MODEL... |
| topic_facet |
Tritrichomonas foetus Modelo ratón Vacuna Tritrichomonas foetus Mouse model vaccine |
| description |
The purpose of this work was to present an experimental murine model as an alternative to the bovine one, to evaluate the efficacy of experimental vaccines against Tritrichomonas foetus. The vaccines employed consisted of inactivated protozoa with different formulations: (A) with oil adjuvant, (B) aqueous vaccine, (C) aqueous vaccine with dimethyl sulphoside. Seventy female BALB/c mice were used and distributed in 7 experimental groups; each group received 2 doses of vaccine, two groups received a vaginal booster at the time of the second dose. Fifteen days after the second dose, all animals were challenged by vaginal instillation with T. fetus. Blood samples and vaginal mucus were taken until day 30 post infection. The immune response was evaluated by ELISA and the vaginal infection assessed by vaginal mucus culture in the TYM medium. The greatest immune response was related to a lower number of infected animals post challenge and a rapid elimination of the protozoa of the reproductive tract. These results allow us to present an alternative experimental model and inexpensive to evaluate power test of current commercial vaccines and new developments of immunogens against bovine trichomonosis. |
| format |
Artículo Artículo publishedVersion |
| author |
Soto, P. Echeverría, H.M. Doumecq, M.L. Cacciato, C.S. Rodriguez, E. Monteavaro, C.E. |
| author_facet |
Soto, P. Echeverría, H.M. Doumecq, M.L. Cacciato, C.S. Rodriguez, E. Monteavaro, C.E. |
| author_sort |
Soto, P. |
| title |
InVet. 2018, 20 (1-2): 23-32 EXPERIMENTAL ISSN 1514-6634 (impreso) MODEL... |
| title_short |
InVet. 2018, 20 (1-2): 23-32 EXPERIMENTAL ISSN 1514-6634 (impreso) MODEL... |
| title_full |
InVet. 2018, 20 (1-2): 23-32 EXPERIMENTAL ISSN 1514-6634 (impreso) MODEL... |
| title_fullStr |
InVet. 2018, 20 (1-2): 23-32 EXPERIMENTAL ISSN 1514-6634 (impreso) MODEL... |
| title_full_unstemmed |
InVet. 2018, 20 (1-2): 23-32 EXPERIMENTAL ISSN 1514-6634 (impreso) MODEL... |
| title_sort |
invet. 2018, 20 (1-2): 23-32 experimental issn 1514-6634 (impreso) model... |
| publisher |
Universidad de Buenos Aires. Facultad de Ciencias Veterinarias. |
| publishDate |
2018 |
| url |
http://repositoriouba.sisbi.uba.ar/gsdl/cgi-bin/library.cgi?a=d&c=pveterinaria/invet&cl=CL1&d=HWA_3615 https://repositoriouba.sisbi.uba.ar/gsdl/collect/pveterinaria/invet/index/assoc/HWA_3615.dir/3615.PDF |
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I28-R145-HWA_36152024-11-05 InVet. 2018, 20 (1-2): 23-32 EXPERIMENTAL ISSN 1514-6634 (impreso) MODEL... The purpose of this work was to present an experimental murine model as an alternative to the bovine one, to evaluate the efficacy of experimental vaccines against Tritrichomonas foetus. The vaccines employed consisted of inactivated protozoa with different formulations: (A) with oil adjuvant, (B) aqueous vaccine, (C) aqueous vaccine with dimethyl sulphoside. Seventy female BALB/c mice were used and distributed in 7 experimental groups; each group received 2 doses of vaccine, two groups received a vaginal booster at the time of the second dose. Fifteen days after the second dose, all animals were challenged by vaginal instillation with T. fetus. Blood samples and vaginal mucus were taken until day 30 post infection. The immune response was evaluated by ELISA and the vaginal infection assessed by vaginal mucus culture in the TYM medium. The greatest immune response was related to a lower number of infected animals post challenge and a rapid elimination of the protozoa of the reproductive tract. These results allow us to present an alternative experimental model and inexpensive to evaluate power test of current commercial vaccines and new developments of immunogens against bovine trichomonosis. Fil: Soto, P. CONICET. Centro de Investigación Veterinaria de Tandil (CIVETAN). Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Departamento de Sanidad Animal y Medicina Preventiva. Tandil, Argentina Fil: Echevarría, H.M. CONICET. Centro de Investigación Veterinaria de Tandil (CIVETAN). Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Departamento de Sanidad Animal y Medicina Preventiva. Tandil, Argentina Fil: Doumecq, M.L. CONICET. Centro de Investigación Veterinaria de Tandil (CIVETAN). Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Departamento de Sanidad Animal y Medicina Preventiva. Tandil, Argentina Fil: Cacciato, C.S. CONICET. Centro de Investigación Veterinaria de Tandil (CIVETAN). Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Departamento de Sanidad Animal y Medicina Preventiva. Tandil, Argentina Fil: Rodriguez, E. CONICET. Centro de Investigación Veterinaria de Tandil (CIVETAN). Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Departamento de Sanidad Animal y Medicina Preventiva. Tandil, Argentina Fil: Monteavaro, C.E. CONICET. Centro de Investigación Veterinaria de Tandil (CIVETAN). Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Departamento de Sanidad Animal y Medicina Preventiva. Tandil, Argentina Soto, P. Echeverría, H.M. Doumecq, M.L. Cacciato, C.S. Rodriguez, E. Monteavaro, C.E. 2018 El objetivo del trabajo fue presentar un modelo experimental alternativo al bovino, para evaluar la eficacia de vacunas experimentales contra Tritrichomonas foetus. Las vacunas ensayadas se formularon con protozoários inactivados y diferentes adyuvantes: (A) con adyuvante oleoso, (B) vacuna acuosa, (C) vacuna acuosa con dimetilsulfósido. Se utilizaron 70 ratones hembras BALB/c distribuídos en 7 lotes experimentales; cada lote recibió 2 dosis de vacuna, dos lotes recibieron un booster vaginal al momento de la segunda dosis. Quince días posteriores a la segunda dosis, todos los animales fueron desafiados via vaginal con T. foetus. Muestras de sangre y mucus vaginal fueron tomadas hasta el día 30 pos infección. La respuesta inmune fue evaluada mediante un test de ELISA y la infección vaginal por cultivo de mucus vaginal en médio TYM. La mayor respuesta inmune se relacionó con un menor número de animales infectados pos desafío y una rápida eliminación de los protozoarios del tracto reproductor. Estos resultados nos permiten presentar un modelo alternativo y económico para evaluar las pruebas de potencia de las actuales vacunas comerciales y\nlos nuevos desarrollos de inmunógenos contra la trichomonosis bovina. application/pdf 1514-6634 (impreso) 1668-3498 (en línea) Tritrichomonas foetus Modelo ratón Vacuna Tritrichomonas foetus Mouse model vaccine eng Universidad de Buenos Aires. Facultad de Ciencias Veterinarias. info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-nd/2.5/ar/ InVet, vol. 20, nº1 Experimental model to assess the Tritrichomonas foetus vaccine- induced effects info:eu-repo/semantics/article info:ar-repo/semantics/artículo info:eu-repo/semantics/publishedVersion http://repositoriouba.sisbi.uba.ar/gsdl/cgi-bin/library.cgi?a=d&c=pveterinaria/invet&cl=CL1&d=HWA_3615 https://repositoriouba.sisbi.uba.ar/gsdl/collect/pveterinaria/invet/index/assoc/HWA_3615.dir/3615.PDF |