Mitochondrial characterization and redox state in submandibular glands of rats exposed to environmental hypoxia

Hypobaric hypoxia (HX) can be defined as a decrease in the partial pressure of oxygen (O2) leading to less levels of this gas in the tissues. HX evokes highly coordinated cellular responses in order to preserve cell viability and they differ from those populations that live permanently at high altit...

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Autor principal: Terrizzi, Antonela Romina
Otros Autores: Fisch, Paul
Formato: Tesis de maestría acceptedVersion
Lenguaje:Inglés
Publicado: Facultad de Farmacia y Bioquímica 2017
Materias:
Hipoxia
Mitocondrias
Glándulas submaxilar
Hypoxia
Mitochondrial
Submandibular glands
Ciencias de la vida
Acceso en línea:http://repositoriouba.sisbi.uba.ar/gsdl/cgi-bin/library.cgi?a=d&c=afamaster&cl=CL1&d=HWA_2813
http://repositoriouba.sisbi.uba.ar/gsdl/collect/afamaster/index/assoc/HWA_2813.dir/2813.PDF
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Repositorio Digital de la Universidad de Buenos Aires (UBA) de Universidad de Buenos Aires
id I28-R145-HWA_2813
record_format dspace
spelling I28-R145-HWA_28132022-02-16 Hypobaric hypoxia (HX) can be defined as a decrease in the partial pressure of oxygen (O2) leading to less levels of this gas in the tissues. HX evokes highly coordinated cellular responses in order to preserve cell viability and they differ from those populations that live permanently at high altitude (chronic continuous hypoxia, CCH) compared to those who work in HX conditions and then return to normoxic environments (chronic intermittent HX, CIH). Despite the fact that the effects of HX in the organism are well established, its role on oral health is still not clear. It has been reported salivary dysfunction in rats exposed to HX, but the mechanisms are still unknown, especially under these two types of HX conditions. In this sense, exposure to HX is known to increase cellular oxidative stress with consequent damage to lipids, proteins and DNA. As mitochondria are the most important organelle related with reactive oxygen species production, it is the aim of this master thesis to evaluate mitochondrial function in submandibular glands in a model of rats submitted to chronic hypobaric hypoxia during 3 months, in order to elucidate the mechanisms involved in glandular secretion at high altitude. Fil: Terrizzi, Antonela Romina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Buenos Aires, Argentina Fisch, Paul Martinez, María del Pilar Facultad de Farmacia y Bioquímica Zaobornyj, Tamara Terrizzi, Antonela Romina 2017-03-27 application/pdf Valdez, Laura La Padula, Pablo Borner, Christoph Hipoxia Mitocondrias Glándulas submaxilar Hypoxia Mitochondrial Submandibular glands eng Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by-nc-nd/2.5/ar/ Ciencias de la vida Mitochondrial characterization and redox state in submandibular glands of rats exposed to environmental hypoxia Caracterización de mitocondrias y estado redox de la glándula submaxilar de ratas expuestas a hipoxia ambiental info:eu-repo/semantics/masterThesis info:ar-repo/semantics/tesis de maestría info:eu-repo/semantics/acceptedVersion http://repositoriouba.sisbi.uba.ar/gsdl/cgi-bin/library.cgi?a=d&c=afamaster&cl=CL1&d=HWA_2813 http://repositoriouba.sisbi.uba.ar/gsdl/collect/afamaster/index/assoc/HWA_2813.dir/2813.PDF
institution Universidad de Buenos Aires
institution_str I-28
repository_str R-145
collection Repositorio Digital de la Universidad de Buenos Aires (UBA)
language Inglés
orig_language_str_mv eng
topic Hipoxia
Mitocondrias
Glándulas submaxilar
Hypoxia
Mitochondrial
Submandibular glands
Ciencias de la vida
spellingShingle Hipoxia
Mitocondrias
Glándulas submaxilar
Hypoxia
Mitochondrial
Submandibular glands
Ciencias de la vida
Terrizzi, Antonela Romina
Mitochondrial characterization and redox state in submandibular glands of rats exposed to environmental hypoxia
topic_facet Hipoxia
Mitocondrias
Glándulas submaxilar
Hypoxia
Mitochondrial
Submandibular glands
Ciencias de la vida
description Hypobaric hypoxia (HX) can be defined as a decrease in the partial pressure of oxygen (O2) leading to less levels of this gas in the tissues. HX evokes highly coordinated cellular responses in order to preserve cell viability and they differ from those populations that live permanently at high altitude (chronic continuous hypoxia, CCH) compared to those who work in HX conditions and then return to normoxic environments (chronic intermittent HX, CIH). Despite the fact that the effects of HX in the organism are well established, its role on oral health is still not clear. It has been reported salivary dysfunction in rats exposed to HX, but the mechanisms are still unknown, especially under these two types of HX conditions. In this sense, exposure to HX is known to increase cellular oxidative stress with consequent damage to lipids, proteins and DNA. As mitochondria are the most important organelle related with reactive oxygen species production, it is the aim of this master thesis to evaluate mitochondrial function in submandibular glands in a model of rats submitted to chronic hypobaric hypoxia during 3 months, in order to elucidate the mechanisms involved in glandular secretion at high altitude.
author2 Fisch, Paul
author_facet Fisch, Paul
Terrizzi, Antonela Romina
format Tesis de maestría
Tesis de maestría
acceptedVersion
author Terrizzi, Antonela Romina
author_sort Terrizzi, Antonela Romina
title Mitochondrial characterization and redox state in submandibular glands of rats exposed to environmental hypoxia
title_short Mitochondrial characterization and redox state in submandibular glands of rats exposed to environmental hypoxia
title_full Mitochondrial characterization and redox state in submandibular glands of rats exposed to environmental hypoxia
title_fullStr Mitochondrial characterization and redox state in submandibular glands of rats exposed to environmental hypoxia
title_full_unstemmed Mitochondrial characterization and redox state in submandibular glands of rats exposed to environmental hypoxia
title_sort mitochondrial characterization and redox state in submandibular glands of rats exposed to environmental hypoxia
publisher Facultad de Farmacia y Bioquímica
publishDate 2017
url http://repositoriouba.sisbi.uba.ar/gsdl/cgi-bin/library.cgi?a=d&c=afamaster&cl=CL1&d=HWA_2813
http://repositoriouba.sisbi.uba.ar/gsdl/collect/afamaster/index/assoc/HWA_2813.dir/2813.PDF
work_keys_str_mv AT terrizziantonelaromina mitochondrialcharacterizationandredoxstateinsubmandibularglandsofratsexposedtoenvironmentalhypoxia
AT terrizziantonelaromina caracterizaciondemitocondriasyestadoredoxdelaglandulasubmaxilarderatasexpuestasahipoxiaambiental
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