Evaluación del entorno Redox en el glaucoma : rol protector de la terapia antioxidante
The aims of this study were to establish the antioxidant status in ocular surface, aqueous humor, vitreous humor, optic nerve, brain, lateral geniculate nucleus and primary visual cortex in an experimental rat glaucoma model and to evaluate the possible protective role of the administration of ?-lip...
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| Formato: | Tesis doctoral acceptedVersion |
| Lenguaje: | Español |
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Facultad de Farmacia y Bioquímica
2017
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| Acceso en línea: | http://repositoriouba.sisbi.uba.ar/gsdl/cgi-bin/library.cgi?a=d&c=posgraafa&cl=CL1&d=HWA_2796 http://repositoriouba.sisbi.uba.ar/gsdl/collect/posgraafa/index/assoc/HWA_2796.dir/2796.PDF |
| Aporte de: |
| Sumario: | The aims of this study were to establish the antioxidant status in ocular surface, aqueous humor, vitreous humor, optic nerve, brain, lateral geniculate nucleus and primary visual cortex in an experimental rat glaucoma model and to evaluate the possible protective role of the administration of ?-lipoic acid (100mg/kg) during 7 days.\nThe following markers were evaluated: prooxidants, antioxidant enzymes activities and levels of non-enzymatic antioxidants.\nResults in the experimental glaucoma model showed: an increase of prooxidants, an increase of superoxide dismutase and glutathione peroxidase, a decrease of enzymes involves in glutathione recycling, and a decrease in non-enzymatic antioxidants. Lipoic treatment produced a decrease in prooxidants, an increase of enzymes involves in glutathione recycling, an increase in the levels of non- enzymatic and enzymatic antioxidants. Therapeutic strategies to stop disease progression in glaucoma should also consider central neural degeneration beyond the retina and the optic nerve. Lipoic acid could be used as a novel therapy for reducing oxidative damage in glaucoma considering glaucomatous damage spreads to the brain. Treatment interventions to reduce oxidative\nstress may be important in patients with this disease that is the second leading cause of blindness worldwide. |
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