Evaluación del entorno Redox en el glaucoma : rol protector de la terapia antioxidante
The aims of this study were to establish the antioxidant status in ocular surface, aqueous humor, vitreous humor, optic nerve, brain, lateral geniculate nucleus and primary visual cortex in an experimental rat glaucoma model and to evaluate the possible protective role of the administration of ?-lip...
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| Formato: | Tesis doctoral acceptedVersion |
| Lenguaje: | Español |
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Facultad de Farmacia y Bioquímica
2017
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| Acceso en línea: | http://repositoriouba.sisbi.uba.ar/gsdl/cgi-bin/library.cgi?a=d&c=posgraafa&cl=CL1&d=HWA_2796 http://repositoriouba.sisbi.uba.ar/gsdl/collect/posgraafa/index/assoc/HWA_2796.dir/2796.PDF |
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I28-R145-HWA_27962019-09-25 The aims of this study were to establish the antioxidant status in ocular surface, aqueous humor, vitreous humor, optic nerve, brain, lateral geniculate nucleus and primary visual cortex in an experimental rat glaucoma model and to evaluate the possible protective role of the administration of ?-lipoic acid (100mg/kg) during 7 days.\nThe following markers were evaluated: prooxidants, antioxidant enzymes activities and levels of non-enzymatic antioxidants.\nResults in the experimental glaucoma model showed: an increase of prooxidants, an increase of superoxide dismutase and glutathione peroxidase, a decrease of enzymes involves in glutathione recycling, and a decrease in non-enzymatic antioxidants. Lipoic treatment produced a decrease in prooxidants, an increase of enzymes involves in glutathione recycling, an increase in the levels of non- enzymatic and enzymatic antioxidants. Therapeutic strategies to stop disease progression in glaucoma should also consider central neural degeneration beyond the retina and the optic nerve. Lipoic acid could be used as a novel therapy for reducing oxidative damage in glaucoma considering glaucomatous damage spreads to the brain. Treatment interventions to reduce oxidative\nstress may be important in patients with this disease that is the second leading cause of blindness worldwide. Fil: Reides, Claudia Gabriela. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Buenos Aires, Argentina Ferreira, Sandra María Facultad de Farmacia y Bioquímica Llesuy, Susana Reides, Claudia Gabriela 2017-03-13 Los objetivos fueron evaluar las alteraciones que se producen en el entorno redox en: superficie ocular, humor acuoso, humor vítreo, cabeza del nervio, cerebro y estructuras cerebrales (núcleo geniculado lateral y corteza visual primaria) de ratas sometidas al modelo experimental de glaucoma y evaluar el posible efecto neuroprotector del ácido lipoico administrado en una dosis diaria (100mg/kg) por siete días.\nLos parámetros evaluados para determinar el entorno redox fueron: niveles de prooxidantes, antioxidantes no enzimáticos y enzimáticos.\nEn el glaucoma se observó: aumento de prooxidantes, disminución de antioxidantes no enzimáticos, disminución de enzimas que reciclan glutatión y aumento de algunas enzimas antioxidantes. El lipoico disminuye prooxidantes, aumenta el reciclado del glutatión y los antioxidantes enzimáticos y no enzimáticos.\nEn conclusión el glaucoma es una neuropatía óptica, cuyo daño se proyecta al cerebro, más allá de la retina y del nervio óptico. El desbalance oxidativo se manifiesta por cambios en el entorno redox de áreas cerebrales que son diana del nervio óptico. El ácido lipoico podría ser utilizado como neuroprotector ya que revierte ciertos marcadores de daño evaluados. Terapias que retrasen la progresión del daño neurodegenerativo redundaría en un beneficio en el tratamiento del glaucoma, la mayor causa de ceguera mundial. application/pdf Balaszczuck, Ana Gelpi, Ricardo Suburo, Angela Glaucoma Entorno Redox Ácido lipoíco Antioxidantes Cerebro spa Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by-nc-nd/2.5/ar/ Ciencia de la vida Evaluación del entorno Redox en el glaucoma : rol protector de la terapia antioxidante info:eu-repo/semantics/doctoralThesis info:ar-repo/semantics/tesis doctoral info:eu-repo/semantics/acceptedVersion http://repositoriouba.sisbi.uba.ar/gsdl/cgi-bin/library.cgi?a=d&c=posgraafa&cl=CL1&d=HWA_2796 http://repositoriouba.sisbi.uba.ar/gsdl/collect/posgraafa/index/assoc/HWA_2796.dir/2796.PDF |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-145 |
| collection |
Repositorio Digital de la Universidad de Buenos Aires (UBA) |
| language |
Español |
| orig_language_str_mv |
spa |
| topic |
Glaucoma Entorno Redox Ácido lipoíco Antioxidantes Cerebro Ciencia de la vida |
| spellingShingle |
Glaucoma Entorno Redox Ácido lipoíco Antioxidantes Cerebro Ciencia de la vida Reides, Claudia Gabriela Evaluación del entorno Redox en el glaucoma : rol protector de la terapia antioxidante |
| topic_facet |
Glaucoma Entorno Redox Ácido lipoíco Antioxidantes Cerebro Ciencia de la vida |
| description |
The aims of this study were to establish the antioxidant status in ocular surface, aqueous humor, vitreous humor, optic nerve, brain, lateral geniculate nucleus and primary visual cortex in an experimental rat glaucoma model and to evaluate the possible protective role of the administration of ?-lipoic acid (100mg/kg) during 7 days.\nThe following markers were evaluated: prooxidants, antioxidant enzymes activities and levels of non-enzymatic antioxidants.\nResults in the experimental glaucoma model showed: an increase of prooxidants, an increase of superoxide dismutase and glutathione peroxidase, a decrease of enzymes involves in glutathione recycling, and a decrease in non-enzymatic antioxidants. Lipoic treatment produced a decrease in prooxidants, an increase of enzymes involves in glutathione recycling, an increase in the levels of non- enzymatic and enzymatic antioxidants. Therapeutic strategies to stop disease progression in glaucoma should also consider central neural degeneration beyond the retina and the optic nerve. Lipoic acid could be used as a novel therapy for reducing oxidative damage in glaucoma considering glaucomatous damage spreads to the brain. Treatment interventions to reduce oxidative\nstress may be important in patients with this disease that is the second leading cause of blindness worldwide. |
| author2 |
Ferreira, Sandra María |
| author_facet |
Ferreira, Sandra María Reides, Claudia Gabriela |
| format |
Tesis doctoral Tesis doctoral acceptedVersion |
| author |
Reides, Claudia Gabriela |
| author_sort |
Reides, Claudia Gabriela |
| title |
Evaluación del entorno Redox en el glaucoma : rol protector de la terapia antioxidante |
| title_short |
Evaluación del entorno Redox en el glaucoma : rol protector de la terapia antioxidante |
| title_full |
Evaluación del entorno Redox en el glaucoma : rol protector de la terapia antioxidante |
| title_fullStr |
Evaluación del entorno Redox en el glaucoma : rol protector de la terapia antioxidante |
| title_full_unstemmed |
Evaluación del entorno Redox en el glaucoma : rol protector de la terapia antioxidante |
| title_sort |
evaluación del entorno redox en el glaucoma : rol protector de la terapia antioxidante |
| publisher |
Facultad de Farmacia y Bioquímica |
| publishDate |
2017 |
| url |
http://repositoriouba.sisbi.uba.ar/gsdl/cgi-bin/library.cgi?a=d&c=posgraafa&cl=CL1&d=HWA_2796 http://repositoriouba.sisbi.uba.ar/gsdl/collect/posgraafa/index/assoc/HWA_2796.dir/2796.PDF |
| work_keys_str_mv |
AT reidesclaudiagabriela evaluaciondelentornoredoxenelglaucomarolprotectordelaterapiaantioxidante |
| _version_ |
1766017512978251776 |