Evaluación de parámetro bioquímicos, nutricionales y genéticos en adolescentes como herramienta de prevención de enfermedades: estudio piloto
In Argentina the use of agrochemicals is common in both large agricultural areas and family vegetable gardens. Children and adolescents who live near these crops can be considered as individuals indirectly exposed to pesticides. This situation can represent a health risk for minors who are more sens...
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| Formato: | Tesis de maestría acceptedVersion |
| Lenguaje: | Español |
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Facultad de Farmacia y Bioquímica
2018
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| Acceso en línea: | http://repositoriouba.sisbi.uba.ar/gsdl/cgi-bin/library.cgi?a=d&c=afamaster&cl=CL1&d=HWA_2759 http://repositoriouba.sisbi.uba.ar/gsdl/collect/afamaster/index/assoc/HWA_2759.dir/2759.PDF |
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| Sumario: | In Argentina the use of agrochemicals is common in both large agricultural areas and family vegetable gardens. Children and adolescents who live near these crops can be considered as individuals indirectly exposed to pesticides. This situation can represent a health risk for minors who are more sensitive to environmental pollutants than adults. The objective of this study was to evaluate the health status of two groups of Argentinian adolescents using biochemical parameters, dietary information, and cytogenetic biomarkers of genotoxicity and cytotoxicity. The study groups included 32 adolescents from Montecarlo, who were indirectly exposed to agrochemicals, and 30 adolescents from Exaltación de la Cruz, not exposed to pesticides. The results showed that the levels of total cholesterol, LDL cholesterol, triglycerides, gamma glutamyl transferase, and butyrylcholinesterase (BuChE) were significantly higher (p < 0.05) in males from Exaltación de la Cruz compared with those from Montecarlo. The activity of BuChE was also higher (p < 0.05) in females from this region. Regarding the diet, it was observed that the consumption of citrus, vegetable-like fruits, tubers, and red meat was more frequent (p < 0.05) in Montecarlo. On the other hand, differences in frequency of biomarkers of genetic damage in lymphocytes of adolescents from both regions were not found (p > 0.05). However, the cytome assay in buccal cells revealed that karyorrhectic and pyknotic cells were more frequent (p < 0.05) in the Montecarlo group; whereas the frequencies of cells with nuclear buds, condensed chromatin and karyolysis were higher (p < 0.05) in the Exaltación de la Cruz group. Despite the differences between the parameters and biomarkers evaluated, the adolescents from Montecarlo did not present health impairment probably due to the type and level of exposure to agrochemicals. |
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