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The idiopathic epilepsy, as much in veterinary medicine, as in human medicine, is a disease that affects a great amount of individuals. It is\ncharacterized by seizures without any provable reason, more than a possible\ngenetic predisposition.\nFor both cases the classification of the seizures and t...

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Autor principal:	Vidal Figueredo, Ramiro José
Otros Autores:	Pellegrino, Fernando Carlos
Formato:	Tesis doctoral acceptedVersion
Lenguaje:	Español
Publicado:	Universidad de Buenos Aires. Facultad de Ciencias Veterinarias 2012
Materias:	Electroencefalograma codificado Epilepsia Perros Caninos Epilepsia idiopática Coherencia cerebral Anatomía animal
Acceso en línea:	http://repositoriouba.sisbi.uba.ar/gsdl/cgi-bin/library.cgi?a=d&c=avaposgra&cl=CL1&d=HWA_1560 https://repositoriouba.sisbi.uba.ar/gsdl/collect/avaposgra/index/assoc/HWA_1560.dir/1560.PDF
Aporte de:	Repositorio Digital de la Universidad de Buenos Aires (UBA) de Universidad de Buenos Aires

id	I28-R145-HWA_1560
record_format	dspace
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-145
collection	Repositorio Digital de la Universidad de Buenos Aires (UBA)
language	Español
orig_language_str_mv	spa
topic	Electroencefalograma codificado Epilepsia Perros Caninos Epilepsia idiopática Coherencia cerebral Anatomía animal
spellingShingle	Electroencefalograma codificado Epilepsia Perros Caninos Epilepsia idiopática Coherencia cerebral Anatomía animal Vidal Figueredo, Ramiro José 1560
topic_facet	Electroencefalograma codificado Epilepsia Perros Caninos Epilepsia idiopática Coherencia cerebral Anatomía animal
description	The idiopathic epilepsy, as much in veterinary medicine, as in human medicine, is a disease that affects a great amount of individuals. It is\ncharacterized by seizures without any provable reason, more than a possible\ngenetic predisposition.\nFor both cases the classification of the seizures and the epilepsies is based\non the use of phenotypic criteria like for example the semiological characteristics, the type of stimulus induces that them and the age in which they appear for the first time.In veterinary medicine, it is mentioned that in the majority of the patients the cause of the epilepsy is not identified and consequently, is assumed that they suffer idiopathic epilepsy, by absence of positive findings. From the\nmoment in which their methodology of registry and analyses has been\nstandardized, the EEG plays a fundamental role in the diagnosis of the epilepsies. Nevertheless only it displays pathological graphoelements in 33% of the cases.\nThe neurophysiologists insist on which there is no nervous function exist without a time metric of the signal, be it one simpler motor act or the most complex cognitive act. On the basis of this, the mathematical analysis of the\nEEG, denominated quantified \n electroencephalogram (EEGq) and, in particular,\nthe cerebral coherence would be able to discriminate between the normal and pathological electrical activity.\nThe purpose of this study was to obtain the values normal of cerebral\ncoherence in adult dogs healthy and to evaluate the differences that existed\nwith the values of cerebral coherence in dogs that suffer idiopathic epilepsy,\nto evaluate the possibility of incorporate this study to the diagnosis of the\nidiopathic epilepsy protocol in dogs. For such aim EEG of healthy adult dogs and idiopathic epilepsy adult dogs free of medication at the time of the study were obtained. We worked with\n12 channels electroencephalographic equipment. In order to obtain the EEG registries it was used a program especially designed for computed\nelectroencephalography and reconstruction by brain mapping. The minimum\ntime of registry was of 30 minutes. Restriction of the animal was realized with\nxylazina, in dose of 1 mg/kg. Was utilized for the analysis only electroencephalograms that presented normal plot to the visual analysis,\nwhich is without pathological graphoelements.\nNext at least 15 stationary segments of 2 seconds of duration (epochs)\nfree of artifices were selected. The values of cerebral coherence for\ninterhemispherical combinations (T3-T4 Fp1-Fp2; F3-F4; P3-P4; O1-O2) and intrahemispherical combinations (O-P; O-F; O-Fp; Fp-T; T-O) were obtained. The values of cerebral coherence were obtained from two different ways: a) of the normal form, that is to say cross power spectrum, coherence spectrum (cross correlation) and, phase spectrum b) the average of the coherence of\nthe electroencephalographic alpha and theta bands.\nAccording to our studies, we can describe in the healthy adult dogs the\nexistence of two groups of channels with electrical dynamics different for the\nanalysis from the interhemispherical coherence as much for the\nintrahemispherical analysis of coherence: A) for the interhemispherical\nanalysis the group of dorsal channels (Fp1-Fp2; F3-F4; P3-P4; O1-O2) display the\nPPC in 7,62 Hz.; whereas the group of temporary channels (T3-T4) the value\nof the frequency in which the PPC appears is 5,25 Hz. B) For the intrahemispherical analysis the group of dorsal channels (O-P; O-F; O-Fp)\npresents the PPC to a frequency of 7,58 Hz. and in the group of halo\nchannels (Fp-T and T-O) the value of frequency to which the PPC appears is\n6,30 Hertz. In the idiopathic epileptic dogs we have found that the value of the\nfrequency in which the PPC appears is minor who in the healthy dogs. In all\nevaluated channels the value of the frequency is included within the value of\nthe electroencephalographic theta band (4-7 Hz); nevertheless the differences\nbetween the groups of channels described previously for the\ninterhemispherical and intrahemispherical combinations remain.\nEven though the analysis of the electroencephalographic bands (alpha and theta) show similar data to the classic form of obtain data, work with a great number of values does of this very troublesome analysis and makes difficult the use as daily tool of use in the routine diagnosis.\nThe study of cerebral coherence appears like a useful tool of the EEGq to\ndescribe the cerebral activity, identifying the specific oscillating of the\ncerebral areas, allowing to establish the anatomical connections among them.\nIn this aspect it is able to recognize alterations in the oscillator, in their\nconnections and the participation of them in pathological events, so that it\ncan be used like tool for the diagnosis of electrical alterations. For this reason\ncould be incorporate without difficulty to the protocol of diagnosis of idiopathic epilepsy in dogs.\nFinally we have found that the idiopathic epileptic dogs present a showy\nsimilarity with the findings that have been reported in humans, reason why\ncould be used as model of study of the epilepsy in humans, especially in the\nreferred thing to an instrument of electrical diagnosis.
author2	Pellegrino, Fernando Carlos
author_facet	Pellegrino, Fernando Carlos Vidal Figueredo, Ramiro José
format	Tesis doctoral Tesis doctoral acceptedVersion
author	Vidal Figueredo, Ramiro José
author_sort	Vidal Figueredo, Ramiro José
title	1560
title_short	1560
title_full	1560
title_fullStr	1560
title_full_unstemmed	1560
title_sort	1560
publisher	Universidad de Buenos Aires. Facultad de Ciencias Veterinarias
publishDate	2012
url	http://repositoriouba.sisbi.uba.ar/gsdl/cgi-bin/library.cgi?a=d&c=avaposgra&cl=CL1&d=HWA_1560 https://repositoriouba.sisbi.uba.ar/gsdl/collect/avaposgra/index/assoc/HWA_1560.dir/1560.PDF
work_keys_str_mv	AT vidalfigueredoramirojose 1560 AT vidalfigueredoramirojose estudiodecoherenciacerebralencaninosepilepticosidiopaticos
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spelling	I28-R145-HWA_15602024-08-27 1560 The idiopathic epilepsy, as much in veterinary medicine, as in human medicine, is a disease that affects a great amount of individuals. It is\ncharacterized by seizures without any provable reason, more than a possible\ngenetic predisposition.\nFor both cases the classification of the seizures and the epilepsies is based\non the use of phenotypic criteria like for example the semiological characteristics, the type of stimulus induces that them and the age in which they appear for the first time.In veterinary medicine, it is mentioned that in the majority of the patients the cause of the epilepsy is not identified and consequently, is assumed that they suffer idiopathic epilepsy, by absence of positive findings. From the\nmoment in which their methodology of registry and analyses has been\nstandardized, the EEG plays a fundamental role in the diagnosis of the epilepsies. Nevertheless only it displays pathological graphoelements in 33% of the cases.\nThe neurophysiologists insist on which there is no nervous function exist without a time metric of the signal, be it one simpler motor act or the most complex cognitive act. On the basis of this, the mathematical analysis of the\nEEG, denominated quantified \n electroencephalogram (EEGq) and, in particular,\nthe cerebral coherence would be able to discriminate between the normal and pathological electrical activity.\nThe purpose of this study was to obtain the values normal of cerebral\ncoherence in adult dogs healthy and to evaluate the differences that existed\nwith the values of cerebral coherence in dogs that suffer idiopathic epilepsy,\nto evaluate the possibility of incorporate this study to the diagnosis of the\nidiopathic epilepsy protocol in dogs. For such aim EEG of healthy adult dogs and idiopathic epilepsy adult dogs free of medication at the time of the study were obtained. We worked with\n12 channels electroencephalographic equipment. In order to obtain the EEG registries it was used a program especially designed for computed\nelectroencephalography and reconstruction by brain mapping. The minimum\ntime of registry was of 30 minutes. Restriction of the animal was realized with\nxylazina, in dose of 1 mg/kg. Was utilized for the analysis only electroencephalograms that presented normal plot to the visual analysis,\nwhich is without pathological graphoelements.\nNext at least 15 stationary segments of 2 seconds of duration (epochs)\nfree of artifices were selected. The values of cerebral coherence for\ninterhemispherical combinations (T3-T4 Fp1-Fp2; F3-F4; P3-P4; O1-O2) and intrahemispherical combinations (O-P; O-F; O-Fp; Fp-T; T-O) were obtained. The values of cerebral coherence were obtained from two different ways: a) of the normal form, that is to say cross power spectrum, coherence spectrum (cross correlation) and, phase spectrum b) the average of the coherence of\nthe electroencephalographic alpha and theta bands.\nAccording to our studies, we can describe in the healthy adult dogs the\nexistence of two groups of channels with electrical dynamics different for the\nanalysis from the interhemispherical coherence as much for the\nintrahemispherical analysis of coherence: A) for the interhemispherical\nanalysis the group of dorsal channels (Fp1-Fp2; F3-F4; P3-P4; O1-O2) display the\nPPC in 7,62 Hz.; whereas the group of temporary channels (T3-T4) the value\nof the frequency in which the PPC appears is 5,25 Hz. B) For the intrahemispherical analysis the group of dorsal channels (O-P; O-F; O-Fp)\npresents the PPC to a frequency of 7,58 Hz. and in the group of halo\nchannels (Fp-T and T-O) the value of frequency to which the PPC appears is\n6,30 Hertz. In the idiopathic epileptic dogs we have found that the value of the\nfrequency in which the PPC appears is minor who in the healthy dogs. In all\nevaluated channels the value of the frequency is included within the value of\nthe electroencephalographic theta band (4-7 Hz); nevertheless the differences\nbetween the groups of channels described previously for the\ninterhemispherical and intrahemispherical combinations remain.\nEven though the analysis of the electroencephalographic bands (alpha and theta) show similar data to the classic form of obtain data, work with a great number of values does of this very troublesome analysis and makes difficult the use as daily tool of use in the routine diagnosis.\nThe study of cerebral coherence appears like a useful tool of the EEGq to\ndescribe the cerebral activity, identifying the specific oscillating of the\ncerebral areas, allowing to establish the anatomical connections among them.\nIn this aspect it is able to recognize alterations in the oscillator, in their\nconnections and the participation of them in pathological events, so that it\ncan be used like tool for the diagnosis of electrical alterations. For this reason\ncould be incorporate without difficulty to the protocol of diagnosis of idiopathic epilepsy in dogs.\nFinally we have found that the idiopathic epileptic dogs present a showy\nsimilarity with the findings that have been reported in humans, reason why\ncould be used as model of study of the epilepsy in humans, especially in the\nreferred thing to an instrument of electrical diagnosis. Fil: Vidal Figueredo, Ramiro José. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias. Buenos Aires, Argentina Pellegrino, Fernando Carlos Vidal Figueredo, Ramiro José 2012 La epilepsia idiopática, tanto en medicina veterinaria, como en medicina humana, es una enfermedad que afecta a una gran cantidad de individuos. Se caracteriza por crisis cerebrales sin ninguna causa comprobable, mas que una posible predisposición genética. Para ambos casos la clasificación de las crisis epilépticas y de las epilepsias se basa en la utilización de criterios fenotípicos como por ejemplo las características semiológicas, el tipo de estímulo que las induce y la edad en que aparecen por primera vez. En medicina veterinaria, se menciona que en la mayoría de los pacientes no se identifica la causa de la epilepsia y en consecuencia, se asume que padecen epilepsia idiopática, por ausencia de hallazgos positivos. Desde el momento en que se han estandarizado su metodología de registro y análisis, el EEG juega un papel fundamental en el diagnóstico de las epilepsias. Sin embargo sólo presenta grafoelementos patlológicos en el 33% de los casos. Los neurofisiólogos hacen hincapié en que no hay función nerviosa que no se halle regida por una métrica temporal, desde el acto motor más sencillo hasta la actividad cognitiva más compleja. En base a esto el análisis matemático del EEG, denominado electroencefalograma cuantificado (EEGc) y, en particular, el estudio de la coherencia cerebral sería capaz de discriminar entre la actividad eléctrica normal y la patológica. El objetivo del trabajo fue obtener los valores normales de coherencia cerebral en perros adultos sanos y evaluar las diferencias que existieran con los valores de coherencia cerebral en perros que padecen epilepsia idiopática, para evaluar la posibilidad de incorporar dicho estudio al protocolo de diagnóstico de la epilepsia idiopática en perros. Para tal fin se obtuvieron EEG de perros adultos sanos y perros adultos con epilepsia idiopática y libre de medicación al momento del estudio. Se trabajó con un equipo de EEGrafía de 12 canales. Para obtener los registros EEGráficos se utilizó un programa especialmente diseñado para electroencefalografía computada y reconstrucción por mapeo cerebral. El tiempo mínimo de registro fue de 30 minutos. La restricción de los animales se realizó xylazina en dosis de 1 mg/kg. Se utilizaron para el análisis sólo electroencefalogramas que presentaban trazados normales al análisis visual, es decir, sin grafoelementos patológicos. A continuación se seleccionaron al menos quince segmentos estacionarios de 2 segundos de duración (épocas) libres de artificio. Se obtuvieron los valores de coherencia cerebral para las combinaciones interhemisféricas (T3-T4; Fp1-Fp2; F3-F4; P3-P4; O1-O2) e interhemisféricas (O-P; O-F; O-Fp; Fp-T; T-O) Los valores de coherencia cerebral se obtuvieron de dos maneras diferentes: A) De la forma cotidiana, es decir espectro de potencia cruzado, espectro de coherencia y espectro de fase, b) El promedio de la coherencia de las bandas electroencefalográficas alpha y theta. De acuerdo a nuestros estudios, podemos describir en los perros adultos sanos la existencia de dos grupos de canales con dinámica eléctrica diferente tanto para el análisis de la coherencia interhemisférico como para el análisis de coherencia intrahemisférico: A) Para el análisis interhemisférico el grupo de los canales dorsales (Fp1-Fp2; F3-F4; P2-P4; O1-O2) Presentan el PPC en X 7,62 Hz.; mientras que el grupo de los canales temporales (T3-T4) el valor de la frecuencia al que se presenta el PPC es de X 5,25 Hz. B)Para el análisis intrahemisférico el grupo de canales dorsales (O-P; O-F; O-Fp) presentan el PPC a una frecuencia de X 7,58 Hz. y en el grupo de canales halo (Fp-T; T-O) el valor de referencia al que se presenta es de X 6,30 Hz. En los perros epilépticos idiopáticos hemos hallado que el valor de la frecuencia en el que se presenta el PPC es menor que en los perros sanos. En todos los canales evaluados el valor de la frecuencia se encuentra comprendido dentro del valor de la banda electroencefalográfica theta (4-7 Hz.); sin embargo se mantienen las diferencias entre los grupos de canales descriptos anteriormente para las combinaciones interhemisféricas e intrahemisféricas. Aunque el análisis de las bandas electroencefalográficas (alpha y theta) arroja datos similares a los que arroja la forma clásica de obtener los datos, el trabajo con una gran cantidad de valores hace de éste un análisis muy engorroso y dificulta la utilización como herramienta de uso cotidiana en el diagnóstico rutinario. El estudio de coherencia cerebral se presenta como una herramienta del EEGc útil para describir la actividad cerebral, identificando los osciladores específicos de las áreas cerebrales, permitiendo establecer las conexiones anatómicas entre ellas. En este aspecto es capaz de reconocer alteraciones en los osciladores, en las conexiones y la participación de ellos en eventos patológicos, de manera que puede utilizarse como herramienta para el diagnóstico de alteraciones eléctricas. Por este motivo podría incorporarse sin dificultad al protocolo diagnóstico de epilepsia idiopática en perros. Finalmente hemos hallado que los perros epilépticos idiopáticos presentan una llamativa similitud con los hallazgos que se han reportado en humanos, por lo que podría utilizarse como modelo de estudio de la epilepsia en humanos, especialmente en lo referido a instrumento de diagnóstico eléctrico.\n application/pdf Electroencefalograma codificado Epilepsia Perros spa Universidad de Buenos Aires. Facultad de Ciencias Veterinarias info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-nd/2.5/ar/ Caninos Epilepsia idiopática Coherencia cerebral Anatomía animal Anatomía y Fisiología Doctor de la Universidad de Buenos Aires en Ciencias Veterinarias Estudio de coherencia cerebral en caninos epilépticos idiopáticos info:eu-repo/semantics/doctoralThesis info:ar-repo/semantics/tesis doctoral info:eu-repo/semantics/acceptedVersion http://repositoriouba.sisbi.uba.ar/gsdl/cgi-bin/library.cgi?a=d&c=avaposgra&cl=CL1&d=HWA_1560 https://repositoriouba.sisbi.uba.ar/gsdl/collect/avaposgra/index/assoc/HWA_1560.dir/1560.PDF

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