Differentiation of the OPRM1 and COMT genes in populations of the province of Chaco
It has been reported that the prevalence of complex phenotypes, including those related to certain pathologies and drug response, are largely determined by the variation of coding regions in the genome, and may vary according to the ancestry and geographical origin of populations. In Argentina, the...
Guardado en:
| Autores principales: | , , , |
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| Formato: | Artículo publishedVersion Artículo enviado a un dossier temático |
| Lenguaje: | Español |
| Publicado: |
Instituto de Ciencias Antropológicas, Facultad de Filosofía y Letras, UBA
2022
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| Materias: | |
| Acceso en línea: | https://revistascientificas.filo.uba.ar/index.php/runa/article/view/10829 https://repositoriouba.sisbi.uba.ar/gsdl/cgi-bin/library.cgi?a=d&c=runa&d=10829_oai |
| Aporte de: |
| id |
I28-R145-10829_oai |
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| record_format |
dspace |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-145 |
| collection |
Repositorio Digital de la Universidad de Buenos Aires (UBA) |
| language |
Español |
| orig_language_str_mv |
spa |
| topic |
Genetic diversity; Pain genetics; Admixed populations; Native populations; Population structure Diversidade genética; Genética da dor; Populações mistas; Populações nativas; Estrutura populacional. |
| spellingShingle |
Genetic diversity; Pain genetics; Admixed populations; Native populations; Population structure Diversidade genética; Genética da dor; Populações mistas; Populações nativas; Estrutura populacional. González, Rebeca Hohl, Diana M. Glesmann, Laura A. Catanesi, CeciliaI. Differentiation of the OPRM1 and COMT genes in populations of the province of Chaco |
| topic_facet |
Genetic diversity; Pain genetics; Admixed populations; Native populations; Population structure Diversidade genética; Genética da dor; Populações mistas; Populações nativas; Estrutura populacional. |
| description |
It has been reported that the prevalence of complex phenotypes, including those related to certain pathologies and drug response, are largely determined by the variation of coding regions in the genome, and may vary according to the ancestry and geographical origin of populations. In Argentina, the province of Chaco presents a great population diversity, given by the coexistence of communities of both native and foreign origin, whose genetic basis in relation to complex phenotypes has not been studied in depth. This work contributes to knowing the diversity of Chaco populations of different origin, finding out significant differences for the variation of OPRM1 and COMT genes which modulate the transmission of the painful sensation and the response to analgesics. In the future, such diversity should be taken into account in medical decisions for the treatment and prevention of pain in each patient, as it is the trend in personalized genomic medicine. |
| format |
Artículo publishedVersion Artículo enviado a un dossier temático |
| author |
González, Rebeca Hohl, Diana M. Glesmann, Laura A. Catanesi, CeciliaI. |
| author_facet |
González, Rebeca Hohl, Diana M. Glesmann, Laura A. Catanesi, CeciliaI. |
| author_sort |
González, Rebeca |
| title |
Differentiation of the OPRM1 and COMT genes in populations of the province of Chaco |
| title_short |
Differentiation of the OPRM1 and COMT genes in populations of the province of Chaco |
| title_full |
Differentiation of the OPRM1 and COMT genes in populations of the province of Chaco |
| title_fullStr |
Differentiation of the OPRM1 and COMT genes in populations of the province of Chaco |
| title_full_unstemmed |
Differentiation of the OPRM1 and COMT genes in populations of the province of Chaco |
| title_sort |
differentiation of the oprm1 and comt genes in populations of the province of chaco |
| publisher |
Instituto de Ciencias Antropológicas, Facultad de Filosofía y Letras, UBA |
| publishDate |
2022 |
| url |
https://revistascientificas.filo.uba.ar/index.php/runa/article/view/10829 https://repositoriouba.sisbi.uba.ar/gsdl/cgi-bin/library.cgi?a=d&c=runa&d=10829_oai |
| work_keys_str_mv |
AT gonzalezrebeca differentiationoftheoprm1andcomtgenesinpopulationsoftheprovinceofchaco AT hohldianam differentiationoftheoprm1andcomtgenesinpopulationsoftheprovinceofchaco AT glesmannlauraa differentiationoftheoprm1andcomtgenesinpopulationsoftheprovinceofchaco AT catanesiceciliai differentiationoftheoprm1andcomtgenesinpopulationsoftheprovinceofchaco AT gonzalezrebeca diferenciaciondelosgenesoprm1ycomtenpoblacionesdelaprovinciadechaco AT hohldianam diferenciaciondelosgenesoprm1ycomtenpoblacionesdelaprovinciadechaco AT glesmannlauraa diferenciaciondelosgenesoprm1ycomtenpoblacionesdelaprovinciadechaco AT catanesiceciliai diferenciaciondelosgenesoprm1ycomtenpoblacionesdelaprovinciadechaco AT gonzalezrebeca diferenciacaodosgenesoprm1ecomtempopulacoesdaprovinciadechaco AT hohldianam diferenciacaodosgenesoprm1ecomtempopulacoesdaprovinciadechaco AT glesmannlauraa diferenciacaodosgenesoprm1ecomtempopulacoesdaprovinciadechaco AT catanesiceciliai diferenciacaodosgenesoprm1ecomtempopulacoesdaprovinciadechaco |
| _version_ |
1851374949033312256 |
| spelling |
I28-R145-10829_oai2025-11-17 González, Rebeca Hohl, Diana M. Glesmann, Laura A. Catanesi, CeciliaI. 2022-05-19 It has been reported that the prevalence of complex phenotypes, including those related to certain pathologies and drug response, are largely determined by the variation of coding regions in the genome, and may vary according to the ancestry and geographical origin of populations. In Argentina, the province of Chaco presents a great population diversity, given by the coexistence of communities of both native and foreign origin, whose genetic basis in relation to complex phenotypes has not been studied in depth. This work contributes to knowing the diversity of Chaco populations of different origin, finding out significant differences for the variation of OPRM1 and COMT genes which modulate the transmission of the painful sensation and the response to analgesics. In the future, such diversity should be taken into account in medical decisions for the treatment and prevention of pain in each patient, as it is the trend in personalized genomic medicine. Se ha demostrado que los fenotipos complejos, entre ellos los referidos a ciertas patologías y respuesta a fármacos, están determinados en gran medida por secuencias codificantes del genoma y pueden variar según la ancestría y procedencia geográfica de las poblaciones. En Argentina, la provincia de Chaco presenta una gran diversidad poblacional dada por la coexistencia de comunidades nativas y foráneas, cuya base genética en relación con fenotipos complejos no ha sido estudiada en profundidad. El presente trabajo contribuye al conocimiento de la diversidad de las poblaciones chaqueñas, mostrando diferencias significativas en la variación de los genes OPRM1 y COMT, que modulan la transmisión de la sensación dolorosa y la respuesta a analgésicos. En el futuro, esta diversidad podrá ser tomada en cuenta en decisiones médicas para el tratamiento y prevención del dolor en cada paciente, como es la tendencia de la medicina genómica personalizada. Foi demonstrado que fenótipos complexos, incluindo aqueles relacionados a certas patologias e respostas a drogas, são amplamente determinados por sequências de codificação do genoma e podem variar de acordo com a ancestralidade e a origem geográfica das populações. Na Argentina, a província do Chaco apresenta uma grande diversidade populacional devido à coexistência de comunidades nativas e estrangeiras, cuja base genética em relação a fenótipos complexos não foi estudada em profundidade. O presente trabalho contribui para o conhecimento da diversidade das populações do Chaco, mostrando diferenças significativas na variação dos genes OPRM1 e COMT, que modulam a transmissão da sensação dolorosa e a resposta aos analgésicos. No futuro, essa diversidade poderá ser levada em conta nas decisões médicas de tratamento e prevenção da dor de cada paciente, como é a tendência da medicina genômica personalizada. application/pdf text/html https://revistascientificas.filo.uba.ar/index.php/runa/article/view/10829 10.34096/runa.v43i2.10829 spa Instituto de Ciencias Antropológicas, Facultad de Filosofía y Letras, UBA https://revistascientificas.filo.uba.ar/index.php/runa/article/view/10829/10258 https://revistascientificas.filo.uba.ar/index.php/runa/article/view/10829/10386 RUNA, archivo para las ciencias del hombre; Vol. 43 No. 2 (2022): Dossier: Biological Anthropology; 157-172 RUNA, archivo para las ciencias del hombre; Vol. 43 Núm. 2 (2022): Dossier: Antropología Biológica; 157-172 RUNA, archivo para las ciencias del hombre; v. 43 n. 2 (2022): Dossiê: Antropologia Biológica; 157-172 1851-9628 0325-1217 Genetic diversity; Pain genetics; Admixed populations; Native populations; Population structure Diversidade genética; Genética da dor; Populações mistas; Populações nativas; Estrutura populacional. Differentiation of the OPRM1 and COMT genes in populations of the province of Chaco Diferenciación de los genes OPRM1 y COMT en poblaciones de la provincia de Chaco Diferenciação dos genes OPRM1 e COMT em populações da província de Chaco info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Artículo enviado a un dossier temático https://repositoriouba.sisbi.uba.ar/gsdl/cgi-bin/library.cgi?a=d&c=runa&d=10829_oai |