Monepatel and the control of Haemonchus contortus in sheep. Efficacy assessment after four years of use in reduced refugia
Resistance to anthelmintics in sheep nematode is widespread in central-northern Argentina and current major concern is the rise and spread of Haemonchus contortus carrying multiple resistance alleles. Currently, monepantel and derquantel are the only broad-spectrum anthelmintics without documentatio...
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| Formato: | Artículo revista |
| Lenguaje: | Español |
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Universidad Nacional del Litoral
2016
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| Acceso en línea: | https://bibliotecavirtual.unl.edu.ar/publicaciones/index.php/FAVEveterinaria/article/view/5411 |
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I26-R133-article-54112018-11-07T12:54:31Z Monepatel and the control of Haemonchus contortus in sheep. Efficacy assessment after four years of use in reduced refugia Monepatel y control de Haemonchus contortus en ovinos. Evaluación de la eficacia luego de cuatro años de uso en condiciones de refugio reducido TORRENTS, Jorgelina SUAREZ ARCHILLA, Guillermo A. ANZIANI, Oscar S Haemonchus sheep monepatel Argentina Haemonchus monepatel Argentina ovinos Resistance to anthelmintics in sheep nematode is widespread in central-northern Argentina and current major concern is the rise and spread of Haemonchus contortus carrying multiple resistance alleles. Currently, monepantel and derquantel are the only broad-spectrum anthelmintics without documentation of resistance in our country. With the first of these drugs, have already been registered cases of resistance in Uruguay and Brazil so it is critical update on the activity in the field of these anthelmintics. This study aims to test the effectiveness of monepantel after four years of use of this drug on an isolation of H. contortus with multiple resistance (macrocyclic lactones, closantel, levamisole and benzimidazole) and under conditions of reduced refugia. Two experiences, A and B (2014 and 2016 respectively), were carried out with lambs naturally parasitized and selected by the number of eggs per gram of feces (≥ 250). In both experiences, the test of reduction in egg counts after treatment with monepantel (2.5 mgr/Kg orally) comparing various formulas indicated that the drug remained with efficacy greater than 97% after four years of use to control this isolation of H. contortus under the field conditions of these studies. La resistencia de los nematodes ovinos a los antihelmínticos está generalizada en el centro-norte de la Argentina y la mayor preocupación actual es el aumento y dispersión de Haemonchus contortus portando alelos con resistencia múltiple. Actualmente los únicos antihelmínticos de amplio espectro sin documentación de resistencia en nuestro país son el monepantel y derquantel. Con la primera de estas drogas ya se han registrado casos de resistencia en Uruguay y Brasil por lo que es crítica la información actualizada sobre la actividad en el campo de estos antihelmínticos. Este estudio informa sobre la eficacia del monepantel luego de cuatro años de uso de esta droga sobre un aislamiento de H. contortus con resistencia múltiple (lactonas macrociclicas, closantel, levamisol y benzimidazoles) y bajo condiciones de refugio reducido. Se realizaron dos experiencias A y B (años 2014 y 2016 respectivamente) con corderos naturalmente parasitados y seleccionados en función del número de huevos por gramo de heces (≥ 250) los que fueron tratados con monepantel (2,5 mg/Kg oral). El test de reducción en el conteo de huevos post tratamiento comparando diversas fórmulas indicó que en ambas experiencias, la droga mantuvo una eficacia mayor al 97 % y que permanece activa para controlar este aislamiento de H. contortus luego de cuatro años de uso y bajo las particulares condiciones en las que se realizaron estos estudios. Universidad Nacional del Litoral 2016-04-15 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Artículo original Original article application/pdf https://bibliotecavirtual.unl.edu.ar/publicaciones/index.php/FAVEveterinaria/article/view/5411 10.14409/favecv.v14i1/2.5411 FAVE Sección Ciencias Veterinarias; Vol. 14 Núm. 1/2 (2015): FAVE Sección Ciencias Veterinarias; 23-27 FAVE Sección Ciencias Veterinarias; Vol. 14 No. 1/2 (2015): FAVE Sección Ciencias Veterinarias; 23-27 FAVE Sección Ciencias Veterinarias; v. 14 n. 1/2 (2015): FAVE Sección Ciencias Veterinarias; 23-27 2362-5589 1666-938X 10.14409/favecv.v14i1/2 spa https://bibliotecavirtual.unl.edu.ar/publicaciones/index.php/FAVEveterinaria/article/view/5411/8101 |
| institution |
Universidad Nacional del Litoral |
| institution_str |
I-26 |
| repository_str |
R-133 |
| container_title_str |
Biblioteca Virtual - Publicaciones (UNL) |
| language |
Español |
| format |
Artículo revista |
| topic |
Haemonchus sheep monepatel Argentina Haemonchus monepatel Argentina ovinos |
| spellingShingle |
Haemonchus sheep monepatel Argentina Haemonchus monepatel Argentina ovinos TORRENTS, Jorgelina SUAREZ ARCHILLA, Guillermo A. ANZIANI, Oscar S Monepatel and the control of Haemonchus contortus in sheep. Efficacy assessment after four years of use in reduced refugia |
| topic_facet |
Haemonchus sheep monepatel Argentina Haemonchus monepatel Argentina ovinos |
| author |
TORRENTS, Jorgelina SUAREZ ARCHILLA, Guillermo A. ANZIANI, Oscar S |
| author_facet |
TORRENTS, Jorgelina SUAREZ ARCHILLA, Guillermo A. ANZIANI, Oscar S |
| author_sort |
TORRENTS, Jorgelina |
| title |
Monepatel and the control of Haemonchus contortus in sheep. Efficacy assessment after four years of use in reduced refugia |
| title_short |
Monepatel and the control of Haemonchus contortus in sheep. Efficacy assessment after four years of use in reduced refugia |
| title_full |
Monepatel and the control of Haemonchus contortus in sheep. Efficacy assessment after four years of use in reduced refugia |
| title_fullStr |
Monepatel and the control of Haemonchus contortus in sheep. Efficacy assessment after four years of use in reduced refugia |
| title_full_unstemmed |
Monepatel and the control of Haemonchus contortus in sheep. Efficacy assessment after four years of use in reduced refugia |
| title_sort |
monepatel and the control of haemonchus contortus in sheep. efficacy assessment after four years of use in reduced refugia |
| description |
Resistance to anthelmintics in sheep nematode is widespread in central-northern Argentina and current major concern is the rise and spread of Haemonchus contortus carrying multiple resistance alleles. Currently, monepantel and derquantel are the only broad-spectrum anthelmintics without documentation of resistance in our country. With the first of these drugs, have already been registered cases of resistance in Uruguay and Brazil so it is critical update on the activity in the field of these anthelmintics. This study aims to test the effectiveness of monepantel after four years of use of this drug on an isolation of H. contortus with multiple resistance (macrocyclic lactones, closantel, levamisole and benzimidazole) and under conditions of reduced refugia. Two experiences, A and B (2014 and 2016 respectively), were carried out with lambs naturally parasitized and selected by the number of eggs per gram of feces (≥ 250). In both experiences, the test of reduction in egg counts after treatment with monepantel (2.5 mgr/Kg orally) comparing various formulas indicated that the drug remained with efficacy greater than 97% after four years of use to control this isolation of H. contortus under the field conditions of these studies. |
| publisher |
Universidad Nacional del Litoral |
| publishDate |
2016 |
| url |
https://bibliotecavirtual.unl.edu.ar/publicaciones/index.php/FAVEveterinaria/article/view/5411 |
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