Fibrosis quística: estudios microbiológicos de muestras respiratorias de pacientes pediátricos.

Cystic fibrosis is the most common genetic disease in the caucasian population and is characterized by dysfunction of the exocrine glands in the body. Respiratory involvement stems from the thickening of bronchial secretions, leading to obstruction, inflammation, and chronic infection of the lower a...

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Autor principal: Marozzi, Eva Berenice
Formato: Artículo revista
Lenguaje:Español
Publicado: Facultad de Bioquímica y Ciencias Biológicas (UNL) 2025
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Acceso en línea:https://bibliotecavirtual.unl.edu.ar/publicaciones/index.php/FABICIB/article/view/13206
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spelling I26-R133-article-132062025-05-20T18:06:10Z Fibrosis quística: estudios microbiológicos de muestras respiratorias de pacientes pediátricos. Cystic fibrosis: microbiological studies of respiratory samples from pediatric patients. Marozzi, Eva Berenice bacterial prevalence, cystic fibrosis, pediatric, antimicrobials, antimicrobial treatment, colonization-infection, respiratory. fibrosis quística pediatría antimicrobianos vías respiratorias Cystic fibrosis is the most common genetic disease in the caucasian population and is characterized by dysfunction of the exocrine glands in the body. Respiratory involvement stems from the thickening of bronchial secretions, leading to obstruction, inflammation, and chronic infection of the lower airway. Based on this pathogenic foundation, numerous exacerbations or acute superinfections occur, affecting lung function and constituting one of the most significant causes of morbidity and mortality in affected patients. The microorganisms that frequently colonize the respiratory tract of these patients are Staphylococcus aureus, Pseudomonas aeruginosa, and Haemophilus influenzae. This same order was observed in all age groups included in this study. 36.8% of S. aureus isolates were methicillin-resistant, and 11.8% exhibited resistance to erythromycin and clindamycin through the MLSBi mechanism. The highest resistance among P. aeruginosa strains was against amikacin (18.7%). 35.4% of H. influenzae isolates were resistant to ampicillin due to the presence of beta lactamases. Early treatment of respiratory complications with antimicrobials is crucial in improving the survival and prognosis of CF patients.   La fibrosis quística es la enfermedad genética más frecuente en la población caucásica y se caracteriza por disfunción de las glándulas de secreción exocrina del organismo. La afectación respiratoria deriva del espesamiento de las secreciones bronquiales que conduce a la obstrucción, inflamación e infección crónica de la vía aérea inferior. Sobre esta base patogénica se presentan numerosas exacerbaciones o sobreinfecciones agudas que afectan la función pulmonar y que constituyen una de las causas más importantes de morbimortalidad en los pacientes afectados. Los microorganismos que colonizan frecuentemente el tracto respiratorio de estos pacientes son Staphylococcus aureus, Pseudomonas aeruginosa y Haemophilus influenzae. Este mismo orden se observó en todos los grupos etarios incluidos en este trabajo. El 36.8% de los aislamientos de S. aureus fue resistente a meticilina y el 11.8% presentó resistencia a eritromicina y clindamicina por el mecanismo MLSBi. La mayor resistencia de las cepas de P. aeruginosa fue a amikacina (18.7%). El 35.4% de los aislamientos de H. influenzae fueron resistentes a ampicilina por presencia de beta lactamasas. El tratamiento precoz de las complicaciones respiratorias con antimicrobianos es fundamental en la mejoría de la sobrevida de los pacientes en el pronóstico de la FQ.   Facultad de Bioquímica y Ciencias Biológicas (UNL) 2025-05-20 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://bibliotecavirtual.unl.edu.ar/publicaciones/index.php/FABICIB/article/view/13206 10.14409/fabicib.v27i0.13206 FABICIB; Vol. 27 (2024): FABICIB 27 FABICIB; Vol. 27 (2024): FABICIB 27 2362-5546 0329-5559 10.14409/fabicib.v27i spa https://bibliotecavirtual.unl.edu.ar/publicaciones/index.php/FABICIB/article/view/13206/20107 Derechos de autor 2024 Eva Berenice Marozzi https://creativecommons.org/licenses/by-nc-sa/4.0
institution Universidad Nacional del Litoral
institution_str I-26
repository_str R-133
container_title_str Biblioteca Virtual - Publicaciones (UNL)
language Español
format Artículo revista
topic bacterial prevalence, cystic fibrosis, pediatric, antimicrobials, antimicrobial treatment, colonization-infection, respiratory.
fibrosis quística
pediatría
antimicrobianos
vías respiratorias
spellingShingle bacterial prevalence, cystic fibrosis, pediatric, antimicrobials, antimicrobial treatment, colonization-infection, respiratory.
fibrosis quística
pediatría
antimicrobianos
vías respiratorias
Marozzi, Eva Berenice
Fibrosis quística: estudios microbiológicos de muestras respiratorias de pacientes pediátricos.
topic_facet bacterial prevalence, cystic fibrosis, pediatric, antimicrobials, antimicrobial treatment, colonization-infection, respiratory.
fibrosis quística
pediatría
antimicrobianos
vías respiratorias
author Marozzi, Eva Berenice
author_facet Marozzi, Eva Berenice
author_sort Marozzi, Eva Berenice
title Fibrosis quística: estudios microbiológicos de muestras respiratorias de pacientes pediátricos.
title_short Fibrosis quística: estudios microbiológicos de muestras respiratorias de pacientes pediátricos.
title_full Fibrosis quística: estudios microbiológicos de muestras respiratorias de pacientes pediátricos.
title_fullStr Fibrosis quística: estudios microbiológicos de muestras respiratorias de pacientes pediátricos.
title_full_unstemmed Fibrosis quística: estudios microbiológicos de muestras respiratorias de pacientes pediátricos.
title_sort fibrosis quística: estudios microbiológicos de muestras respiratorias de pacientes pediátricos.
description Cystic fibrosis is the most common genetic disease in the caucasian population and is characterized by dysfunction of the exocrine glands in the body. Respiratory involvement stems from the thickening of bronchial secretions, leading to obstruction, inflammation, and chronic infection of the lower airway. Based on this pathogenic foundation, numerous exacerbations or acute superinfections occur, affecting lung function and constituting one of the most significant causes of morbidity and mortality in affected patients. The microorganisms that frequently colonize the respiratory tract of these patients are Staphylococcus aureus, Pseudomonas aeruginosa, and Haemophilus influenzae. This same order was observed in all age groups included in this study. 36.8% of S. aureus isolates were methicillin-resistant, and 11.8% exhibited resistance to erythromycin and clindamycin through the MLSBi mechanism. The highest resistance among P. aeruginosa strains was against amikacin (18.7%). 35.4% of H. influenzae isolates were resistant to ampicillin due to the presence of beta lactamases. Early treatment of respiratory complications with antimicrobials is crucial in improving the survival and prognosis of CF patients.  
publisher Facultad de Bioquímica y Ciencias Biológicas (UNL)
publishDate 2025
url https://bibliotecavirtual.unl.edu.ar/publicaciones/index.php/FABICIB/article/view/13206
work_keys_str_mv AT marozzievaberenice fibrosisquisticaestudiosmicrobiologicosdemuestrasrespiratoriasdepacientespediatricos
AT marozzievaberenice cysticfibrosismicrobiologicalstudiesofrespiratorysamplesfrompediatricpatients
first_indexed 2025-06-15T05:05:09Z
last_indexed 2025-06-15T05:05:09Z
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