Pkarmacokinetic and absolute bioavailability of marbofloxacin in buffaloes (Bubalus bubalis).
The aim of this study was to evaluate the pharmacokinetic behaviour and the absolute bioavailability of marbofloxacin (MFX) in adult water buffaloes and to estimate the pharmacokinetic parameters for calculating the therapeutic dose in this animal species. Six adult buffaloes (3 males and 3 females)...
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| Formato: | Artículo revista |
| Lenguaje: | Español |
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Universidad Nacional del Litoral
2021
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| Acceso en línea: | https://bibliotecavirtual.unl.edu.ar/publicaciones/index.php/FAVEveterinaria/article/view/10913 |
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I26-R133-article-109132021-12-07T14:23:08Z Pkarmacokinetic and absolute bioavailability of marbofloxacin in buffaloes (Bubalus bubalis). FARMACOCINÉTICA Y BIODISPONIBILIDAD ABSOLUTA DE MARBOFLOXACINA EN BÚFALOS (Bubalus bubalis) Anadón, A Marbofloxacin, Pharmacokinetic, Bioavailabiliy, Buffaloes Marbofloxacina, Farmacocinética, Biodisponibilidad, Búfalos The aim of this study was to evaluate the pharmacokinetic behaviour and the absolute bioavailability of marbofloxacin (MFX) in adult water buffaloes and to estimate the pharmacokinetic parameters for calculating the therapeutic dose in this animal species. Six adult buffaloes (3 males and 3 females) where treated by intravenous (IV) and subcutaneous (SC) route with a 10% experimental MFX injectable formulation at the dose of 2 mg/kg. After administration blood samples were drawn at pre-established times and MFX plasma concentrations where determined by microbiologic method. The pharmacokinetic analysis was made by compartmental analysis. After IV administration MFX presented a clearance of 198.4 ± 21.0 mL.kg.h and a half-life of elimination of 7.64 ± 3.29 h. After SC administration marbofloxacin presented a half-life of elimination of 8.5 ± 2.42 h, reaching it maximum plasma concentration (1.67 ± 0.516 μg/mL) at 1.69 ± 0.231 h, with a bioavailability of 80.8 ± 11.2 %. The estimated values of clearance and bioavailability will be employed in further studies for calculating the therapeutic dose of MFX in water buffaloes. Universidad Nacional del Litoral 2021-12-02 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://bibliotecavirtual.unl.edu.ar/publicaciones/index.php/FAVEveterinaria/article/view/10913 10.14409/favecv.v19isuplemento.10913 FAVE Sección Ciencias Veterinarias; Vol. 19 Núm. suplemento (2021): FAVE Sección Ciencias Veterinarias FAVE Sección Ciencias Veterinarias; Vol. 19 No. suplemento (2021): FAVE Sección Ciencias Veterinarias FAVE Sección Ciencias Veterinarias; v. 19 n. suplemento (2021): FAVE Sección Ciencias Veterinarias 2362-5589 1666-938X 10.14409/favecv.v19isuplemento spa https://bibliotecavirtual.unl.edu.ar/publicaciones/index.php/FAVEveterinaria/article/view/10913/14944 |
| institution |
Universidad Nacional del Litoral |
| institution_str |
I-26 |
| repository_str |
R-133 |
| container_title_str |
Biblioteca Virtual - Publicaciones (UNL) |
| language |
Español |
| format |
Artículo revista |
| topic |
Marbofloxacin, Pharmacokinetic, Bioavailabiliy, Buffaloes Marbofloxacina, Farmacocinética, Biodisponibilidad, Búfalos |
| spellingShingle |
Marbofloxacin, Pharmacokinetic, Bioavailabiliy, Buffaloes Marbofloxacina, Farmacocinética, Biodisponibilidad, Búfalos Anadón, A Pkarmacokinetic and absolute bioavailability of marbofloxacin in buffaloes (Bubalus bubalis). |
| topic_facet |
Marbofloxacin, Pharmacokinetic, Bioavailabiliy, Buffaloes Marbofloxacina, Farmacocinética, Biodisponibilidad, Búfalos |
| author |
Anadón, A |
| author_facet |
Anadón, A |
| author_sort |
Anadón, A |
| title |
Pkarmacokinetic and absolute bioavailability of marbofloxacin in buffaloes (Bubalus bubalis). |
| title_short |
Pkarmacokinetic and absolute bioavailability of marbofloxacin in buffaloes (Bubalus bubalis). |
| title_full |
Pkarmacokinetic and absolute bioavailability of marbofloxacin in buffaloes (Bubalus bubalis). |
| title_fullStr |
Pkarmacokinetic and absolute bioavailability of marbofloxacin in buffaloes (Bubalus bubalis). |
| title_full_unstemmed |
Pkarmacokinetic and absolute bioavailability of marbofloxacin in buffaloes (Bubalus bubalis). |
| title_sort |
pkarmacokinetic and absolute bioavailability of marbofloxacin in buffaloes (bubalus bubalis). |
| description |
The aim of this study was to evaluate the pharmacokinetic behaviour and the absolute bioavailability of marbofloxacin (MFX) in adult water buffaloes and to estimate the pharmacokinetic parameters for calculating the therapeutic dose in this animal species. Six adult buffaloes (3 males and 3 females) where treated by intravenous (IV) and subcutaneous (SC) route with a 10% experimental MFX injectable formulation at the dose of 2 mg/kg. After administration blood samples were drawn at pre-established times and MFX plasma concentrations where determined by microbiologic method. The pharmacokinetic analysis was made by compartmental analysis. After IV administration MFX presented a clearance of 198.4 ± 21.0 mL.kg.h and a half-life of elimination of 7.64 ± 3.29 h. After SC administration marbofloxacin presented a half-life of elimination of 8.5 ± 2.42 h, reaching it maximum plasma concentration (1.67 ± 0.516 μg/mL) at 1.69 ± 0.231 h, with a bioavailability of 80.8 ± 11.2 %. The estimated values of clearance and bioavailability will be employed in further studies for calculating the therapeutic dose of MFX in water buffaloes.
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| publisher |
Universidad Nacional del Litoral |
| publishDate |
2021 |
| url |
https://bibliotecavirtual.unl.edu.ar/publicaciones/index.php/FAVEveterinaria/article/view/10913 |
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AT anadona pkarmacokineticandabsolutebioavailabilityofmarbofloxacininbuffaloesbubalusbubalis AT anadona farmacocineticaybiodisponibilidadabsolutademarbofloxacinaenbufalosbubalusbubalis |
| first_indexed |
2023-07-05T23:06:05Z |
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2023-07-05T23:06:05Z |
| _version_ |
1770623719631224832 |