Social isolation impairs active avoidance performance and decreases neurogenesis in the dorsomedial telencephalon of rainbow trout

Alterations in the social environment, such as isolating an individual that would normally live in a social group, can generate physiological responses that compromise an individual's capacity to learn. To investigate this, we tested whether social isolation impairs learning skills in the rainb...

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Detalles Bibliográficos
Autores principales: Ausas, María Soledad, Mazzitelli Fuentes, Laura, Roman, Fernanda Ruth, Crichigno, Sonia Alejandra, De Vincenti, Ana Paula, Mongiat, Lucas Alberto
Formato: Articulo article acceptedVersion
Lenguaje:Inglés
Publicado: Elsevier 2019
Materias:
Oncorhynchus mykiss
Trucha arcoiris
Neurogénesis
Ciencias de la Tierra y Medio Ambiente
Acceso en línea:http://rdi.uncoma.edu.ar/handle/uncomaid/17269
Aporte de:
Repositorio Institucional UNCo de Universidad Nacional del Comahue
id I22-R178-uncomaid-17269
record_format dspace
institution Universidad Nacional del Comahue
institution_str I-22
repository_str R-178
collection Repositorio Institucional UNCo
language Inglés
topic Oncorhynchus mykiss
Trucha arcoiris
Neurogénesis
Ciencias de la Tierra y Medio Ambiente
spellingShingle Oncorhynchus mykiss
Trucha arcoiris
Neurogénesis
Ciencias de la Tierra y Medio Ambiente
Ausas, María Soledad
Mazzitelli Fuentes, Laura
Roman, Fernanda Ruth
Crichigno, Sonia Alejandra
De Vincenti, Ana Paula
Mongiat, Lucas Alberto
Social isolation impairs active avoidance performance and decreases neurogenesis in the dorsomedial telencephalon of rainbow trout
topic_facet Oncorhynchus mykiss
Trucha arcoiris
Neurogénesis
Ciencias de la Tierra y Medio Ambiente
description Alterations in the social environment, such as isolating an individual that would normally live in a social group, can generate physiological responses that compromise an individual's capacity to learn. To investigate this, we tested whether social isolation impairs learning skills in the rainbow trout. We show that rainbow trout can achieve an active avoidance (AA) learning program with inter-individual variability. Moreover, c-Fos expression in dorsomedial telencephalon (Dm) correlates with the AA performance, indicating that this structure is involved in this cognitive task. Given that Dm participates in AA learning and this region is under plastic remodelling by addition of new-born neurons, we tested whether social isolation impinges on adult neurogenesis and, consequently, on the Dm cognitive outcome. Trout were reared for four weeks in control or isolated conditions. We found that social isolation diminished the percentage of adult-born neurons that are being incorporated into Dm network. Interestingly, the same isolation treatment also induced a severe deficit in the AA performance. Our results demonstrate a structure-to-function relationship between the Dm and the learning ability in an AA task, indicate that social isolation reduces the incorporation of adult-born neurons into Dm, and show that social isolation impairs the Dm-related cognitive function.
format Articulo
article
acceptedVersion
author Ausas, María Soledad
Mazzitelli Fuentes, Laura
Roman, Fernanda Ruth
Crichigno, Sonia Alejandra
De Vincenti, Ana Paula
Mongiat, Lucas Alberto
author_facet Ausas, María Soledad
Mazzitelli Fuentes, Laura
Roman, Fernanda Ruth
Crichigno, Sonia Alejandra
De Vincenti, Ana Paula
Mongiat, Lucas Alberto
author_sort Ausas, María Soledad
title Social isolation impairs active avoidance performance and decreases neurogenesis in the dorsomedial telencephalon of rainbow trout
title_short Social isolation impairs active avoidance performance and decreases neurogenesis in the dorsomedial telencephalon of rainbow trout
title_full Social isolation impairs active avoidance performance and decreases neurogenesis in the dorsomedial telencephalon of rainbow trout
title_fullStr Social isolation impairs active avoidance performance and decreases neurogenesis in the dorsomedial telencephalon of rainbow trout
title_full_unstemmed Social isolation impairs active avoidance performance and decreases neurogenesis in the dorsomedial telencephalon of rainbow trout
title_sort social isolation impairs active avoidance performance and decreases neurogenesis in the dorsomedial telencephalon of rainbow trout
publisher Elsevier
publishDate 2019
url http://rdi.uncoma.edu.ar/handle/uncomaid/17269
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spelling I22-R178-uncomaid-172692023-10-18T13:10:03Z Social isolation impairs active avoidance performance and decreases neurogenesis in the dorsomedial telencephalon of rainbow trout Ausas, María Soledad Mazzitelli Fuentes, Laura Roman, Fernanda Ruth Crichigno, Sonia Alejandra De Vincenti, Ana Paula Mongiat, Lucas Alberto Oncorhynchus mykiss Trucha arcoiris Neurogénesis Ciencias de la Tierra y Medio Ambiente Alterations in the social environment, such as isolating an individual that would normally live in a social group, can generate physiological responses that compromise an individual's capacity to learn. To investigate this, we tested whether social isolation impairs learning skills in the rainbow trout. We show that rainbow trout can achieve an active avoidance (AA) learning program with inter-individual variability. Moreover, c-Fos expression in dorsomedial telencephalon (Dm) correlates with the AA performance, indicating that this structure is involved in this cognitive task. Given that Dm participates in AA learning and this region is under plastic remodelling by addition of new-born neurons, we tested whether social isolation impinges on adult neurogenesis and, consequently, on the Dm cognitive outcome. Trout were reared for four weeks in control or isolated conditions. We found that social isolation diminished the percentage of adult-born neurons that are being incorporated into Dm network. Interestingly, the same isolation treatment also induced a severe deficit in the AA performance. Our results demonstrate a structure-to-function relationship between the Dm and the learning ability in an AA task, indicate that social isolation reduces the incorporation of adult-born neurons into Dm, and show that social isolation impairs the Dm-related cognitive function. Fil: Ausas, María Soledad. Universidad Nacional del Comahue. Centro Regional Universitario Bariloche; Argentina. Fil: Ausas, María Soledad. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Biodiversidad y Medioambiente; Argentina. Fil: Ausas, María Soledad. Comisión Nacional de Energía Atómica. Centro Atómico Bariloche. Departamento de Física Médica; Argentina. Fil: Mazzitelli Fuentes, Laura. Universidad Nacional del Comahue. Centro Regional Universitario Bariloche; Argentina. Fil: Mazzitelli Fuentes, Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Biodiversidad y Medioambiente; Argentina. Fil: Mazzitelli Fuentes, Laura. Comisión Nacional de Energía Atómica. Centro Atómico Bariloche. Departamento de Física Médica; Argentina. Fil: Roman, Fernanda Ruth. Universidad Nacional del Comahue. Centro Regional Universitario Bariloche; Argentina. Fil: Roman, Fernanda Ruth. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Biodiversidad y Medioambiente; Argentina. Fil: Roman, Fernanda Ruth. Comisión Nacional de Energía Atómica. Centro Atómico Bariloche. Departamento de Física Médica; Argentina. Fil: Crichigno, Sonia Alejandra. Universidad Nacional del Comahue. Centro Regional Universitario Bariloche; Argentina. Fil: Crichigno, Sonia Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto Andino Patagónico de Tecnologías Biológicas y Geoambientales; Argentina. Fil: De Vincenti, Ana Paula. Universidad Nacional de Buenos Aires; Argentina. Fil: De Vincenti, Ana Paula. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología Celular y Neurociencia. Laboratorio de Neurociencia Molecular y Celular; Argentina. Fil: Mongiat, Lucas Alberto. Universidad Nacional del Comahue. Centro Regional Universitario Bariloche; Argentina. Fil: Mongiat, Lucas Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Biodiversidad y Medioambiente; Argentina. Fil: Mongiat, Lucas Alberto. Comisión Nacional de Energía Atómica. Centro Atómico Bariloche. Departamento de Física Médica; Argentina. 2019-01-01 2023-06-13T16:34:26Z 2023-06-13T16:34:26Z Articulo article acceptedVersion 0031-9384 http://rdi.uncoma.edu.ar/handle/uncomaid/17269 eng https://www.sciencedirect.com/science/article/pii/S0031938418308606?via%3Dihub Atribución-NoComercial-CompartirIgual 2.5 Argentina https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ application/pdf application/pdf Elsevier Physiology & Behavior. Vol. 198 January (2019)

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