Plasma cholinesterase and carboxylesterase activities and nuclear and mitochondrial lipid composition of human placenta associated with maternal exposure to pesticides

Blood cholinesterases and tissue carboxylesterases (CEs) are sensitive indicators of environmental organophosphate pesticides (OPs) exposure. The aim of this pilot study was to assess the impact of OP exposure on placental CE activity and lipid composition. We performed a study of 40 healthy women w...

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Autores principales: Vera, Berta, Santa Cruz, Silvia, Magnarelli, Gladis
Formato: Articulo article acceptedVersion
Lenguaje:Inglés
Publicado: Elsevier 2012
Materias:
Organophosphate pesticides
Carboxylesterase
Lipid composition
Placenta
Ciencias de la Tierra y Medio Ambiente
Ciencias Biomédicas
Acceso en línea:http://rdi.uncoma.edu.ar/handle/uncomaid/15224
Aporte de:
Repositorio Institucional UNCo de Universidad Nacional del Comahue
id I22-R178-uncomaid-15224
record_format dspace
spelling I22-R178-uncomaid-152242023-09-21T14:59:42Z Plasma cholinesterase and carboxylesterase activities and nuclear and mitochondrial lipid composition of human placenta associated with maternal exposure to pesticides Vera, Berta Santa Cruz, Silvia Magnarelli, Gladis Organophosphate pesticides Carboxylesterase Lipid composition Placenta Ciencias de la Tierra y Medio Ambiente Ciencias Biomédicas Blood cholinesterases and tissue carboxylesterases (CEs) are sensitive indicators of environmental organophosphate pesticides (OPs) exposure. The aim of this pilot study was to assess the impact of OP exposure on placental CE activity and lipid composition. We performed a study of 40 healthy women who live in agricultural farms. Samples were collected during the pulverization period (PP) and recess period (RP). The plasma cholinesterase and placental CE activity decreased in PP, suggesting that women were exposed to OPs and that these pesticides reached the placenta. The cardiolipin content increased and the phosphatidylethanolamine content decreased in the light mitochondrial fraction while total cholesterol and sphingomyelin increased in the nuclear fraction. These changes in lipid profiles suggest repair by hyperplasia of the cytotrophoblast. Decreased CE activity may have clinical and toxicological implications and thus entail potential risks to damage fetal growth and development. Fil: Vera, Berta. Universidad Nacional del Comahue. Instituto Multidisciplinario de Investigación y Desarrollo de la Patagonia Norte; Argentina. Fil: Vera, Berta. Universidad Nacional del Comahue. Facultad de Ciencias Médicas; Argentina. Fil: Vera, Berta. Concejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Fil: Magnarelli, Gladis. Universidad Nacional del Comahue. Facultad de Ingeniería. Instituto Multidisciplinario de Investigación y Desarrollo de la Patagonia Norte; Argentina. Fil: Magnarelli, Gladis. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Fil: Magnarelli, Gladis. Universidad Nacional del Comahue. Facultad Ciencias Médicas; Argentina. Fil: Santa Cruz, Silvia. Hospital Área Programa Cinco Saltos. Rio Negro; Argentina. 2012-04 2019-05-30T18:01:34Z 2019-05-30T18:01:34Z Articulo article acceptedVersion http://rdi.uncoma.edu.ar/handle/uncomaid/15224 0890-6238 eng https://www.journals.elsevier.com/reproductive-toxicology Atribución-NoComercial-SinDerivadas 2.5 Argentina https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ application/pdf pp. 402-407 application/pdf Elsevier Board ReproductiveToxicology 34 (2012)
institution Universidad Nacional del Comahue
institution_str I-22
repository_str R-178
collection Repositorio Institucional UNCo
language Inglés
topic Organophosphate pesticides
Carboxylesterase
Lipid composition
Placenta
Ciencias de la Tierra y Medio Ambiente
Ciencias Biomédicas
spellingShingle Organophosphate pesticides
Carboxylesterase
Lipid composition
Placenta
Ciencias de la Tierra y Medio Ambiente
Ciencias Biomédicas
Vera, Berta
Santa Cruz, Silvia
Magnarelli, Gladis
Plasma cholinesterase and carboxylesterase activities and nuclear and mitochondrial lipid composition of human placenta associated with maternal exposure to pesticides
topic_facet Organophosphate pesticides
Carboxylesterase
Lipid composition
Placenta
Ciencias de la Tierra y Medio Ambiente
Ciencias Biomédicas
description Blood cholinesterases and tissue carboxylesterases (CEs) are sensitive indicators of environmental organophosphate pesticides (OPs) exposure. The aim of this pilot study was to assess the impact of OP exposure on placental CE activity and lipid composition. We performed a study of 40 healthy women who live in agricultural farms. Samples were collected during the pulverization period (PP) and recess period (RP). The plasma cholinesterase and placental CE activity decreased in PP, suggesting that women were exposed to OPs and that these pesticides reached the placenta. The cardiolipin content increased and the phosphatidylethanolamine content decreased in the light mitochondrial fraction while total cholesterol and sphingomyelin increased in the nuclear fraction. These changes in lipid profiles suggest repair by hyperplasia of the cytotrophoblast. Decreased CE activity may have clinical and toxicological implications and thus entail potential risks to damage fetal growth and development.
format Articulo
article
acceptedVersion
author Vera, Berta
Santa Cruz, Silvia
Magnarelli, Gladis
author_facet Vera, Berta
Santa Cruz, Silvia
Magnarelli, Gladis
author_sort Vera, Berta
title Plasma cholinesterase and carboxylesterase activities and nuclear and mitochondrial lipid composition of human placenta associated with maternal exposure to pesticides
title_short Plasma cholinesterase and carboxylesterase activities and nuclear and mitochondrial lipid composition of human placenta associated with maternal exposure to pesticides
title_full Plasma cholinesterase and carboxylesterase activities and nuclear and mitochondrial lipid composition of human placenta associated with maternal exposure to pesticides
title_fullStr Plasma cholinesterase and carboxylesterase activities and nuclear and mitochondrial lipid composition of human placenta associated with maternal exposure to pesticides
title_full_unstemmed Plasma cholinesterase and carboxylesterase activities and nuclear and mitochondrial lipid composition of human placenta associated with maternal exposure to pesticides
title_sort plasma cholinesterase and carboxylesterase activities and nuclear and mitochondrial lipid composition of human placenta associated with maternal exposure to pesticides
publisher Elsevier
publishDate 2012
url http://rdi.uncoma.edu.ar/handle/uncomaid/15224
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AT santacruzsilvia plasmacholinesteraseandcarboxylesteraseactivitiesandnuclearandmitochondriallipidcompositionofhumanplacentaassociatedwithmaternalexposuretopesticides
AT magnarelligladis plasmacholinesteraseandcarboxylesteraseactivitiesandnuclearandmitochondriallipidcompositionofhumanplacentaassociatedwithmaternalexposuretopesticides
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