Plasma cholinesterase and carboxylesterase activities and nuclear and mitochondrial lipid composition of human placenta associated with maternal exposure to pesticides
Blood cholinesterases and tissue carboxylesterases (CEs) are sensitive indicators of environmental organophosphate pesticides (OPs) exposure. The aim of this pilot study was to assess the impact of OP exposure on placental CE activity and lipid composition. We performed a study of 40 healthy women w...
Guardado en:
| Autores principales: | , , |
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| Formato: | Articulo article acceptedVersion |
| Lenguaje: | Inglés |
| Publicado: |
Elsevier
2012
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| Materias: | |
| Acceso en línea: | http://rdi.uncoma.edu.ar/handle/uncomaid/15224 https://www.journals.elsevier.com/reproductive-toxicology |
| Aporte de: |
| id |
I22-R178-uncomaid-15224 |
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| record_format |
dspace |
| institution |
Universidad Nacional del Comahue |
| institution_str |
I-22 |
| repository_str |
R-178 |
| collection |
Repositorio Institucional UNCo |
| language |
Inglés |
| topic |
Organophosphate pesticides Carboxylesterase Lipid composition Placenta Ciencias de la Tierra y Medio Ambiente Ciencias Biomédicas |
| spellingShingle |
Organophosphate pesticides Carboxylesterase Lipid composition Placenta Ciencias de la Tierra y Medio Ambiente Ciencias Biomédicas Vera, Berta Santa Cruz, Silvia Magnarelli, Gladis Plasma cholinesterase and carboxylesterase activities and nuclear and mitochondrial lipid composition of human placenta associated with maternal exposure to pesticides |
| topic_facet |
Organophosphate pesticides Carboxylesterase Lipid composition Placenta Ciencias de la Tierra y Medio Ambiente Ciencias Biomédicas |
| description |
Blood cholinesterases and tissue carboxylesterases (CEs) are sensitive indicators of environmental organophosphate pesticides (OPs) exposure. The aim of this pilot study was to assess the impact of OP exposure on placental CE activity and lipid composition. We performed a study of 40 healthy women who live in agricultural farms. Samples were collected during the pulverization period (PP) and recess period (RP). The plasma cholinesterase and placental CE activity decreased in PP, suggesting that women were exposed to OPs and that these pesticides reached the placenta. The cardiolipin content increased and the phosphatidylethanolamine content decreased in the light mitochondrial fraction while total cholesterol and sphingomyelin increased in the nuclear fraction. These changes in lipid profiles suggest repair by hyperplasia of the cytotrophoblast. Decreased CE activity may have clinical and toxicological implications and thus entail potential risks to damage fetal growth and development. |
| format |
Articulo article acceptedVersion |
| author |
Vera, Berta Santa Cruz, Silvia Magnarelli, Gladis |
| author_facet |
Vera, Berta Santa Cruz, Silvia Magnarelli, Gladis |
| author_sort |
Vera, Berta |
| title |
Plasma cholinesterase and carboxylesterase activities and nuclear and mitochondrial lipid composition of human placenta associated with maternal exposure to pesticides |
| title_short |
Plasma cholinesterase and carboxylesterase activities and nuclear and mitochondrial lipid composition of human placenta associated with maternal exposure to pesticides |
| title_full |
Plasma cholinesterase and carboxylesterase activities and nuclear and mitochondrial lipid composition of human placenta associated with maternal exposure to pesticides |
| title_fullStr |
Plasma cholinesterase and carboxylesterase activities and nuclear and mitochondrial lipid composition of human placenta associated with maternal exposure to pesticides |
| title_full_unstemmed |
Plasma cholinesterase and carboxylesterase activities and nuclear and mitochondrial lipid composition of human placenta associated with maternal exposure to pesticides |
| title_sort |
plasma cholinesterase and carboxylesterase activities and nuclear and mitochondrial lipid composition of human placenta associated with maternal exposure to pesticides |
| publisher |
Elsevier |
| publishDate |
2012 |
| url |
http://rdi.uncoma.edu.ar/handle/uncomaid/15224 https://www.journals.elsevier.com/reproductive-toxicology |
| work_keys_str_mv |
AT veraberta plasmacholinesteraseandcarboxylesteraseactivitiesandnuclearandmitochondriallipidcompositionofhumanplacentaassociatedwithmaternalexposuretopesticides AT santacruzsilvia plasmacholinesteraseandcarboxylesteraseactivitiesandnuclearandmitochondriallipidcompositionofhumanplacentaassociatedwithmaternalexposuretopesticides AT magnarelligladis plasmacholinesteraseandcarboxylesteraseactivitiesandnuclearandmitochondriallipidcompositionofhumanplacentaassociatedwithmaternalexposuretopesticides |
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Repositorios |
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