Single nucleotide polymorphisms in ATM, TNF-α and IL6 genes and risk of radiotoxicity in breast cancer patients

Although oncological therapies have improved in the last decades, breast cancer (BC) remains a serious health problem worldwide. Radiotherapy (RT) is one of the most frequently used treatments for cancer aimed at eliminating tumor cells. However, it can also alter the surrounding normal tissue, espe...

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Detalles Bibliográficos
Autores principales: Córdoba, Elisa Eugenia, Lacunza, Ezequiel, Abba, Martín Carlos, Fernández, Eduardo Francisco, Güerci, Alba Mabel
Formato: Articulo Preprint
Lenguaje:Inglés
Publicado: 2018
Materias:
Bioquímica
Breast cancer
Polymorphisms
Radiosensitivity
Radiotherapy
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/99664
https://ri.conicet.gov.ar/11336/86893
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-99664
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Bioquímica
Breast cancer
Polymorphisms
Radiosensitivity
Radiotherapy
spellingShingle Bioquímica
Breast cancer
Polymorphisms
Radiosensitivity
Radiotherapy
Córdoba, Elisa Eugenia
Lacunza, Ezequiel
Abba, Martín Carlos
Fernández, Eduardo Francisco
Güerci, Alba Mabel
Single nucleotide polymorphisms in ATM, TNF-α and IL6 genes and risk of radiotoxicity in breast cancer patients
topic_facet Bioquímica
Breast cancer
Polymorphisms
Radiosensitivity
Radiotherapy
description Although oncological therapies have improved in the last decades, breast cancer (BC) remains a serious health problem worldwide. Radiotherapy (RT) is one of the most frequently used treatments for cancer aimed at eliminating tumor cells. However, it can also alter the surrounding normal tissue, especially the skin, and patient reactions may vary as a result of extrinsic and intrinsic factors. We evaluated the association of gene polymorphisms ATM Asp1853Asn, IL-6 G-174C and TNF-α G-308A involved in central phenotype pathways and development of individual radiosensitivity in BC patients with an exacerbated response to RT. Although univariate analysis results did not show a significant association with this trait, the interaction analysis between polymorphisms showed an increased risk of patients presenting wild-type TNF-α G-308A genotype and mutant IL-6 G-174C genotype, and heterozygous TNF-α G-308A genotype and heterozygous IL-6G-174C genotype. On the other hand, our results showed that breast size and patient age influenced the determination of RT-associated effects. Considering that the trait is multifactorial, other significant elements for the determination of individual radiosensitivity should be considered, together with the establishment of specific polymorphic variants.
format Articulo
Preprint
author Córdoba, Elisa Eugenia
Lacunza, Ezequiel
Abba, Martín Carlos
Fernández, Eduardo Francisco
Güerci, Alba Mabel
author_facet Córdoba, Elisa Eugenia
Lacunza, Ezequiel
Abba, Martín Carlos
Fernández, Eduardo Francisco
Güerci, Alba Mabel
author_sort Córdoba, Elisa Eugenia
title Single nucleotide polymorphisms in ATM, TNF-α and IL6 genes and risk of radiotoxicity in breast cancer patients
title_short Single nucleotide polymorphisms in ATM, TNF-α and IL6 genes and risk of radiotoxicity in breast cancer patients
title_full Single nucleotide polymorphisms in ATM, TNF-α and IL6 genes and risk of radiotoxicity in breast cancer patients
title_fullStr Single nucleotide polymorphisms in ATM, TNF-α and IL6 genes and risk of radiotoxicity in breast cancer patients
title_full_unstemmed Single nucleotide polymorphisms in ATM, TNF-α and IL6 genes and risk of radiotoxicity in breast cancer patients
title_sort single nucleotide polymorphisms in atm, tnf-α and il6 genes and risk of radiotoxicity in breast cancer patients
publishDate 2018
url http://sedici.unlp.edu.ar/handle/10915/99664
https://ri.conicet.gov.ar/11336/86893
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