Tailoring doxorubicin sustainable release from biopolymeric smart matrix using congo red as molecular helper

Doxorubicin (Dox) was co-encapsulated with congo red (CR) in order to increase drug encapsulation and sustain the release from gel microbeads composed of alginate–carboxy methyl guar gum (68/32) for oral controlled delivery. No release of either cargo molecule from the microbeads at pH 1.2 within 90...

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Autores principales: Bosio, Valeria Elizabeth, Gómez López, Azucena, Mukherjee, Arup, Mechetti, Magdalena, Castro, Guillermo Raúl
Formato: Articulo Preprint
Lenguaje:Inglés
Publicado: 2014
Materias:
Química
Doxorrubicin
Drug delivery
Alginate - guar gum
Biopolymers
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/99439
https://ri.conicet.gov.ar/11336/16071
http://pubs.rsc.org/en/Content/ArticleLanding/2014/TB/C3TB20531B#!divAbstract
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-99439
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Química
Doxorrubicin
Drug delivery
Alginate - guar gum
Biopolymers
spellingShingle Química
Doxorrubicin
Drug delivery
Alginate - guar gum
Biopolymers
Bosio, Valeria Elizabeth
Gómez López, Azucena
Mukherjee, Arup
Mechetti, Magdalena
Castro, Guillermo Raúl
Tailoring doxorubicin sustainable release from biopolymeric smart matrix using congo red as molecular helper
topic_facet Química
Doxorrubicin
Drug delivery
Alginate - guar gum
Biopolymers
description Doxorubicin (Dox) was co-encapsulated with congo red (CR) in order to increase drug encapsulation and sustain the release from gel microbeads composed of alginate–carboxy methyl guar gum (68/32) for oral controlled delivery. No release of either cargo molecule from the microbeads at pH 1.2 within 90 minutes was detected. However, 62% CR and 16% Dox were released from the gels at pH 7.4 at 37 °C in 8 hours when both the cargo molecules were studied alone. Presence of CR in the formulation reduces the release of Dox by about 25–30% under the same experimental conditions. Rheological properties of the formulations have been investigated at different temperatures between 20 and 37 °C. Shear thinning behavior was observed by steady-shear flow experiments for all formulations, and no yield stress was observed for any of the formulations. The temperature effect on Alg–CMGG–Dox–CR evidenced a synergic action between Dox and CR. Dynamic frequency sweep tests were performed to study the viscoelastic properties of the formulations. The patterns observed for Alg–CMGG indicated physical gel characteristics; however, all other formulations showed behaviour typical of concentrated solutions. These results confirm the interaction of Dox and CR, and the concomitant positive effect on sustainable release in oral delivery.
format Articulo
Preprint
author Bosio, Valeria Elizabeth
Gómez López, Azucena
Mukherjee, Arup
Mechetti, Magdalena
Castro, Guillermo Raúl
author_facet Bosio, Valeria Elizabeth
Gómez López, Azucena
Mukherjee, Arup
Mechetti, Magdalena
Castro, Guillermo Raúl
author_sort Bosio, Valeria Elizabeth
title Tailoring doxorubicin sustainable release from biopolymeric smart matrix using congo red as molecular helper
title_short Tailoring doxorubicin sustainable release from biopolymeric smart matrix using congo red as molecular helper
title_full Tailoring doxorubicin sustainable release from biopolymeric smart matrix using congo red as molecular helper
title_fullStr Tailoring doxorubicin sustainable release from biopolymeric smart matrix using congo red as molecular helper
title_full_unstemmed Tailoring doxorubicin sustainable release from biopolymeric smart matrix using congo red as molecular helper
title_sort tailoring doxorubicin sustainable release from biopolymeric smart matrix using congo red as molecular helper
publishDate 2014
url http://sedici.unlp.edu.ar/handle/10915/99439
https://ri.conicet.gov.ar/11336/16071
http://pubs.rsc.org/en/Content/ArticleLanding/2014/TB/C3TB20531B#!divAbstract
work_keys_str_mv AT bosiovaleriaelizabeth tailoringdoxorubicinsustainablereleasefrombiopolymericsmartmatrixusingcongoredasmolecularhelper
AT gomezlopezazucena tailoringdoxorubicinsustainablereleasefrombiopolymericsmartmatrixusingcongoredasmolecularhelper
AT mukherjeearup tailoringdoxorubicinsustainablereleasefrombiopolymericsmartmatrixusingcongoredasmolecularhelper
AT mechettimagdalena tailoringdoxorubicinsustainablereleasefrombiopolymericsmartmatrixusingcongoredasmolecularhelper
AT castroguillermoraul tailoringdoxorubicinsustainablereleasefrombiopolymericsmartmatrixusingcongoredasmolecularhelper
bdutipo_str Repositorios
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